Serum magnesium level and hematoma expansion in patients with intracerebral hemorrhage

Jafari, Mostafa; Napoli, Mario Di; Lattanzi, Simona; Mayer, Stephan A.; Bachour, Salam; Bershad, Eric M.; Damani, Rahul; Datta, Yvonne H.; Divani, Afshin A.

doi:10.1016/j.jns.2019.01.027

Cited by 29 publications

(24 citation statements)

References 78 publications

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“…[ 81 ] In addition, serum magnesium is associated with stroke prognosis. [ 82 ] Magnesium ions has been recognized as a cofactor for > 300 metabolic reactions in the body. It can participate in the synthesis of various substances and the production and storage of cellular energy.…”

Section: Disscussionmentioning

confidence: 99%

Predictors of urinary tract infection in acute stroke patients

Zhao

2020

Medicine

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Patients with stroke have a high risk of infection which may be predicted by age, procalcitonin, interleukin-6, C-reactive protein, National Institute of Health stroke scale (NHSS) score, diabetes, etc. These prediction methods can reduce unfavourable outcome by preventing the occurrence of infection. We aim to identify early predictors for urinary tract infection in patients after stroke. In 186 collected acute stroke patients, we divided them into urinary tract infection group, other infection type groups, and non-infected group. Data were recorded at admission. Independent risk factors and infection prediction model were determined using Logistic regression analyses. Likelihood ratio test was used to detect the prediction effect of the model. Receiver operating characteristic curve and the corresponding area under the curve were used to measure the predictive accuracy of indicators for urinary tract infection. Of the 186 subjects, there were 35 cases of urinary tract infection. Elevated interleukin-6, higher NIHSS, and decreased hemoglobin may be used to predict urinary tract infection. And the predictive model for urinary tract infection (including sex, NIHSS, interleukin-6, and hemoglobin) have the best predictive effect. This study is the first to discover that decreased hemoglobin at admission may predict urinary tract infection. The prediction model shows the best accuracy.

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Section: Disscussionmentioning

confidence: 99%

Predictors of urinary tract infection in acute stroke patients

Zhao

2020

Medicine

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“…The outcome of ICH is affected by several factors, such as low serum magnesium [50], inflammatory response (higher neutrophils and lower lymphocytes) [51], maintenance of cerebral perfusion pressure and drug actions [52,53] through the influence of neurovascular recovery and systemic complications.…”

Section: General Management For Ichmentioning

confidence: 99%

The Role of Urocortins in Intracerebral Hemorrhage

et al. 2020

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Intracerebral hemorrhage (ICH) causes an accumulation of blood in the brain parenchyma that disrupts the normal neurological function of the brain. Despite extensive clinical trials, no medical or surgical therapy has shown to be effective in managing ICH, resulting in a poor prognosis for the patients. Urocortin (UCN) is a 40-amino-acid endogenous neuropeptide that belongs to the corticotropin-releasing hormone (CRH) family. The effect of UCN is activated by binding to two G-protein coupled receptors, CRH-R1 and CRH-R2, which are expressed in brain neurons and glial cells in various brain regions. Current research has shown that UCN exerts neuroprotective effects in ICH models via anti-inflammatory effects, which generally reduced brain edema and reduced blood-brain barrier disruption. These effects gradually help in the improvement of the neurological outcome, and thus, UCN may be a potential therapeutic target in the treatment of ICH. This review summarizes the data published to date on the role of UCN in ICH and the possible protective mechanisms underlined.

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“…(c) Factors affecting clinical outcomes in patients with ICH are complex. Many variables, such as electrolyte imbalance, inflammatory markers, and metabolic factors, may adversely affect the clinical outcomes of ICH, and future work needs to be done to control the confounding effects of factors using multivariate analysis.…”

Section: Limitationsmentioning

confidence: 99%

Therapeutic effect of early intensive antihypertensive treatment on rebleeding and perihematomal edema in acute intracerebral hemorrhage

Zang

Zhang

Song

et al. 2019

J of Clinical Hypertension

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To observe the effect of early intensive blood pressure (BP)–lowering treatment on rebleeding and perihematomal edema (PE) in patients with acute intracerebral hemorrhage (ICH). A total of 121 patients with ICH were randomly assigned to an early intensive antihypertensive treatment group (IG) (n = 62) or control group (CG) (n = 59). For both groups, 25 mg of urapidil injection was slowly administered intravenously in 6 hours of the onset. For the IG, 100 mg of urapidil and 30 mL of 0.9% sodium chloride were then slowly administered. Repeat computed tomography imaging was performed at 24 hours, 72 hours, day 7, and day 14 to detect any rebleeding via changes in hematoma volume and the changes in PE. Finally, NIHSS scores and Barthel Index (BI) were calculated at 24 hours, 72 hours, day 7, day 14, day 30, and day 90. The average hematoma volume in IG patients was significantly smaller than that of CG patients after 24 hours (P < .05). The volume of PE in the CG increased more than in the IG within 24 hours of onset, but was not statistically significant (P > .05); however, this trend was statistically significant after 72 hours (P < .05). On day 30 and day 90, the average NIHSS score of IG patients was lower than that of CG patients, and the BI was higher (P < .05) than that of CG patients. There was no significant difference in mortality between the two groups. Early intensive antihypertensive treatment in ICH patients reduces rebleeding and PE, improving short‐term quality of life.

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Serum magnesium level and hematoma expansion in patients with intracerebral hemorrhage

Cited by 29 publications

References 78 publications

Predictors of urinary tract infection in acute stroke patients

Predictors of urinary tract infection in acute stroke patients

The Role of Urocortins in Intracerebral Hemorrhage

Therapeutic effect of early intensive antihypertensive treatment on rebleeding and perihematomal edema in acute intracerebral hemorrhage

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