Serum magnesium levels in asthmatic patients during acute exacerbations of asthma

Falkner, Douglas; Glauser, Jonathan; Allen, Marc S.

doi:10.1016/0735-6757(92)90114-d

Cited by 34 publications

(18 citation statements)

References 6 publications

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“…Further, considering only magnesium levels in the serum, it is possible to overlook an intracellular hypomagnesaemia [3], which may correspond to a true reduction in total body stores of the ion. In fact, and in agreement with our results regarding serum magnesium levels, Falkner et al [45] found no difference in this parameter in patients with asthma during acute exacerbation compared with a non-asthmatic population. They concluded that serum magnesium measurements are not clinically useful for predicting the severity of the attack, nor are they predictive of the response to magnesium infusion [45].…”

Section: Discussionsupporting

confidence: 93%

Bronchial reactivity and intracellular magnesium: a possible mechanism for the bronchodilating effects of magnesium in asthma

Domínguez¹,

Barbagallo²,

LORENZO³

et al. 1998

Clinical Science

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1. Increased bronchial smooth muscle contractility with consequent bronchial hyperreactivity are characteristic physiopathological events of asthma. Since magnesium intervenes in calcium transport mechanisms and intracellular phosphorylation reactions, it constitutes an important determinant of the contraction/relaxation state of bronchial smooth muscle. In the present study we investigated the relationship between bronchial reactivity, assessed by methacholine-provocation test, and magnesium concentrations both at extracellular and intracellular levels measured by spectrophotometry. Twenty-two patients with mild-to-moderate asthma and 38 non-asthmatic subjects with allergic rhinitis (24 allergic to Parietaria pollen and 14 allergic to Grass pollen) were recruited to the study. Exclusion criteria included renal failure, hepatic diseases, heart failure and arterial hypertension. 2. The salient finding of our study is that there is a strong positive correlation between bronchial reactivity and the level of intracellular magnesium (r=0.72, P<0.0001), both when the groups are analysed separately or together. Intracellular magnesium concentrations in the group of patients with asthma were significantly lower (1.8+/-0. 01 mmol/l; n=22) when compared with levels in rhinitis subjects allergic to Parietaria (1.9+/-0.01 mmol/l; n=24, P<0.05), and with levels in rhinitis subjects allergic to Grass pollen (2.0+/-0.03 mmol/l; n=14, P<0.05). Serum levels of the ion were similar in all groups. 3. We conclude that the level of intracellular magnesium may be an important determinant of bronchial hyperreactivity, as supported by the significant positive correlation between these two parameters in allergic patients with known bronchial hyperresponsiveness. This finding, in addition to reports of the bronchodilating effects of magnesium administration in patients with asthma, confirms the proposed role of this ion in the pathogenesis and treatment of asthma.

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Section: Discussionsupporting

confidence: 93%

Bronchial reactivity and intracellular magnesium: a possible mechanism for the bronchodilating effects of magnesium in asthma

Domínguez¹,

Barbagallo²,

LORENZO³

et al. 1998

Clinical Science

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“…Low serum Mg levels in adult asthmatic patients have been described many years ago (9,29). Contrarily, some studies reported no difference between asthmatic patients and normal individuals, in terms of serum magnesium levels (10,11). In Turkey, Deveci et al (13) measured serum electrolytes in adults receiving chronic asthma treatment and determined hypomagnesaemia in 56.6% of patients.…”

Section: Eurasianmentioning

confidence: 99%

“…It is used in the treatment of acute asthma attack owing to its bronchodilator effect, by reversing bronchospasm. Serum Mg levels have been investigated in adult patients with asthma; whilst some studies found Mg levels to be low in these patients, some studies did not corroborate these findings (9)(10)(11). In Turkey, studies on Mg levels in patients with asthma include adult patients (12,13).…”

Section: Introductionmentioning

confidence: 99%

Serum Magnesium Concentration in Children with Asthma

Hatipoğlu¹,

Hatipoğlu²,

Türel³

et al. 2014

Eurasian J Pulmonol

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Objective: Asthma is the most common chronic disease of childhood, and magnesium is one of the most frequently found minerals in human body and it is used in the treatment of asthma. Although there are studies on magnesium levels in adult patients with asthma, there is yet no data on the levels of magnesium in children. The present study compared the levels of serum magnesium between the children with asthma and healthy children. Methods:Children aged between 5 and 17 years with mild-moderate persistent asthma, who were admitted to our hospital between January 2009 and August 2010, were included in the study. Serum magnesium levels were measured in 50 patients with acute asthma attack, in 50 patients receiving treatment for stable asthma, and in 50 children admitted to the hospital for any reason and matched with asthma patients except for the diagnosis of asthma. The test was performed by photometric method using Roche-Hitachi Modular P biochemistry analyzer. The normal range of serum Mg was considered to be 1.59-to-2.10 mg/dL and p<0.05 was considered statistically significant. Results:All three groups were similar in terms of mean age and gender distribution. Although mean serum magnesium levels were within the normal range in healthy children and in children treated for stable asthma (1.89±0.32 and 1.93±0.34 mg/dL respectively), it was 1.62±0.26 mg/dL in children having an asthma attack, which was within the normal range but close to the lower limit (p<0.001). Conclusion:Although its efficacy has not been definitely proven, magnesium is used either via intravenous route or as inhaler in acute asthma attack. Knowledge about the changes in body magnesium levels of asthma patients would be a guide for revealing the role of magnesium in the treatment of asthma. As was shown in the present study, magnesium levels tend to decrease in the body during acute attack.

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“…In a study of twins, Duffy, et al did not demonstrate any difference in total serum magnesium between patients with and without asthma [14]. Falkner et al [15] studied asthmatics during acute exacerbations versus non-asthmatic controls. The subjects were matched for age, race, gender, and socio-economic status.…”

Section: Discussionmentioning

confidence: 97%

Ionized magnesium levels and the ratio of ionized calcium to magnesium in asthma patients before and after treatment with magnesium

Sinert

Spektor

Gorlin

et al. 2005

Scandinavian Journal of Clinical and Laboratory Investigation

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Serum magnesium levels in asthmatic patients during acute exacerbations of asthma

Cited by 34 publications

References 6 publications

Bronchial reactivity and intracellular magnesium: a possible mechanism for the bronchodilating effects of magnesium in asthma

Bronchial reactivity and intracellular magnesium: a possible mechanism for the bronchodilating effects of magnesium in asthma

Serum Magnesium Concentration in Children with Asthma

Ionized magnesium levels and the ratio of ionized calcium to magnesium in asthma patients before and after treatment with magnesium

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