Serum Magnesium Levels in Seizure Disorders

Krishna, C. Rama; Basha, Salman; Rao, B. Venkateswara; Preethi, B.

doi:10.14260/jemds/2014/3202

jemds

2014

DOI: 10.14260/jemds/2014/3202

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Serum Magnesium Levels in Seizure Disorders

C. Rama Krishna¹,

Salman Basha²,

B. Venkateswara Rao³

et al.

Abstract: The objective of this study is to estimate the serum magnesium levels in seizure disorders and its possible association with the occurrence of seizures. Blood sample for serum magnesium and other electrolytes (blood glucose, potassium, sodium, calcium, chloride) were taken during the period from the onset of seizures up to 72 hours. DESIGN: The present study is a prospective study carried out at King George Hospital, Visakhapatnam. MATERIALS & METHODS: The present study was carried out on 50 subjects diagnosed… Show more

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A Study of Serum Calcium and Magnesium Levels in Idiopathic Epilepsy Patients of Hubli, Karnataka, India

Kachapur¹,

Kallimani²,

B.H³

et al. 2021

jebmh

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BACKGROUND Magnesium is a potential modulator of seizure activity because of its ability to antagonize the excitatory calcium influx through N-methyl-D-aspartate (NMDA) receptor which is thought to play a role in many human forms of epilepsy. When the extracellular concentration of calcium ion falls below normal, the nervous system becomes more excitable, allowing easy initiation of action potentials. Consequently, hypocalcaemia causes seizures because of its action of increasing excitability in the brain. We wanted to estimate the serum concentration of calcium and magnesium in idiopathic epilepsy patients and its co-relation. METHODS 94 cases of idiopathic epilepsy with breakthrough seizures admitted to KIMS Hospital, Hubli, meeting the inclusion criteria were considered for the study which was for 2-years’ time period. It’s a single centred, time bound and cross sectional study. RESULTS Mean serum calcium was low 8.36 ± 0.45 mg / dL and mean serum magnesium was 1.79 ± 0.28 mg / dL. 64.9 % had total serum calcium less than 8.5 mg / dL and 44.7 % had serum magnesium of < 1.8 mg / dL. 35.1 % had both low calcium and magnesium. There was significant difference in mean serum calcium with respect to number of episodes. There was no significant difference in mean serum magnesium with respect to number of episodes. CONCLUSIONS Serum calcium and magnesium levels which play a role in seizure initiation should be measured in all idiopathic epilepsy patients with breakthrough seizures as a seizure trigger. Considering the role of calcium and magnesium in the pathophysiology of seizures and by evaluating the results from the present study, breakthrough seizure could be provoked by hypocalcaemia and hypomagnesemia. Hence they may be used for the treatment of intractable seizures. KEYWORDS Calcium, Magnesium, Idiopathic Epilepsy

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A Study of Serum Calcium and Magnesium Levels in Idiopathic Epilepsy Patients of Hubli, Karnataka, India

Kachapur¹,

Kallimani²,

B.H³

et al. 2021

jebmh

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To Study the Prevalence of Electrolyte Imbalance in Patients With Seizures

Sonkar

Singh

Srivastava

2022

Global Journal for Research Analysis

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Background: Seizure is dened as an episode of neurological dysfunction caused by abnormal neuronal activity that results in a sudden change in motor, behaviour and sensory perception1. Electrolytes seem to have a dominant role in the causation of seizures Electrolyte homeostasis in the central nervous system (CNS) is a characteristic essential feature behind brain functioning. “A number of clinical studies have also shown a relationship between electrolyte imbalance and seizures. OBJECTIVE: To Determine the Prevalence of electrolyte imbalance in patients with Seizures. RESEARCH DESIGN AND METHODS: A cross sectional study was conducted at , MLN Medical College associated SRN Hospital, Prayagraj. A total 100 patients were enrolled in the study. Patients with 18 years of age or older presented with seizure as the presenting complaint were included. Patients presenting with cerebrovascular accident ,subarachnoid hemorrhage, tuberculoma cavernous sinus thrombosis febrile seizures hypoglycemia alcohol withdrawal uremic encephalopathy and patients refusing to participate in the study. RESULT: Nearly two third (64%) patients had generalized tonic clonic seizures followed by focal seizures (27%) and status epilepticus (9%) respectively. Maximum electrolyte imbalance was seen for calcium (99%) followed by sodium (92%), potassium (63%) and magnesium (33%) respectively. A signicant association of serum sodium status was observed with type of seizures with hyponatremia being more common in GTCS and hypernatremia being more common in status epilepticus. Conclusion: In the present study, there was a high prevalence of hyponatremia (82%). Hyponatremia could be one of the most common factors leading to seizure activity. The ndings of the present study shows that both in adults as well as in children show that electrolyte imbalance is a frequent observation in seizure activity, primarily cation deciency is highly prevalent in seizure cases, however it is difcult to establish the role of a single electrolyte cation to be responsible for this activity

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Serum Magnesium Levels in Seizure Disorders

Cited by 2 publications

References 8 publications

A Study of Serum Calcium and Magnesium Levels in Idiopathic Epilepsy Patients of Hubli, Karnataka, India

A Study of Serum Calcium and Magnesium Levels in Idiopathic Epilepsy Patients of Hubli, Karnataka, India

To Study the Prevalence of Electrolyte Imbalance in Patients With Seizures

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