Serum malondialdehyde level: Surrogate stress marker in the Sikkimese diabetics

Bhutia, Yazum; Ghosh, Amrita; Sherpa, Mingma; Pal, Ranabir; Mohanta, Pradip Kumar

doi:10.4103/0976-9668.82309

Cited by 61 publications

(9 citation statements)

References 23 publications

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“…T2D and PDM subjects exhibited higher levels of the plasma lipid peroxidation marker, MDA. The rise in plasma MDA among T2D has been previously reported similar to our findings [34, 35]. Hyperglycaemia promotes ROS-mediated lipid peroxidation via nonenzymatic and autoglycation pathways [1, 7].…”

Section: Discussionsupporting

confidence: 91%

Poor Glycaemic Control Is Associated with Increased Lipid Peroxidation and Glutathione Peroxidase Activity in Type 2 Diabetes Patients

Gunawardena

Silva

Sivakanesan

et al. 2019

Oxidative Medicine and Cellular Longevity

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Glycaemic control is the main focus of managing diabetes and its complications. Hyperglycaemia induces oxidative stress favouring cellular damage and subsequent diabetic complications. The present study was conducted to compare the plasma total antioxidant capacity (TAC) and individual antioxidant marker antioxidant status of type 2 diabetics (T2D) with good ((+) GC) and poor ((-) GC) glycaemic control with prediabetic (PDM) and normoglycaemic (NG) individuals. T2D (n=147), PDM (n=47), and NGC (n=106) were recruited as subjects. T2D and PDM had lower plasma TAG than NG subjects. T2D and PDM had significantly higher GPx activity and plasma MDA concentrations than NG. PDM showed the highest SOD activity. T2D (-) GC showed significantly elevated GPx activity and higher MDA level and significantly lower SOD activity among all study groups. Lower plasma TAC and higher plasma MDA indicate the presence of oxidative stress in T2D and PDM. Elevated GPx activity in T2D, PDM, and particularly in T2D (-) GC suggests a compensatory response to counteract excess lipid peroxidation in the hyperglycaemic state. Decline in SOD activity advocates the presence of glycation and excess lipid peroxidation in T2D.

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Section: Discussionsupporting

confidence: 91%

Poor Glycaemic Control Is Associated with Increased Lipid Peroxidation and Glutathione Peroxidase Activity in Type 2 Diabetes Patients

Gunawardena

Silva

Sivakanesan

et al. 2019

Oxidative Medicine and Cellular Longevity

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“…There are very few studies in the literature, which have shown the association between serum bilirubin and MDA levels with diabetic microvascular complications. [ 17 18 19 20 21 22 23 24 25 ] We hypothesized that there is a correlation between the levels of bilirubin and MDA with severity of retinopathy in patients with type 2 DM. There are no studies showing the association between DR and serum bilirubin in Indian population and only a few are available with MDA levels hence this study was undertaken.…”

Section: Introductionmentioning

confidence: 99%

Association of bilirubin and malondialdehyde levels with retinopathy in type 2 diabetes mellitus

Dave

Kalra

Gowda

et al. 2015

Indian J Endocr Metab

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Introduction:Bilirubin as an antioxidant and malondialdehyde (MDA) as an oxidant have been shown to be associated with various complications of type 2 diabetes mellitus (DM).Aims and Objectives:The aim was to measure the levels of serum bilirubin and MDA in type 2 DM patients with and without diabetic retinopathy (DR) and to correlate them with severity of DR.Materials and Methods:A total number of 120 subjects out of which 40 were controls without type 2 DM and the rest 80 were type 2 DM patients were included in the study. Of those 80 diabetics, 44 patients did not have DR and 36 patients had DR.Results:The total bilirubin, direct bilirubin, indirect bilirubin were higher in controls as compared to cases (P = 0.017, 0.033, 0.024). Serum MDA levels were found to be higher in diabetics as compared to controls (P = 0.00). The values of all the three parameters, that is, total bilirubin, direct bilirubin and indirect bilirubin were lower in patients with retinopathy as compared to those without retinopathic changes (P = 0.00, 0.020, and 0.007). Subjects were assigned to quartiles based on serum total bilirubin concentration. The prevalence of DR was significantly lower among persons with the highest bilirubin quartile compared to those with the lowest quartile. The severity of DR was inversely proportional to the total bilirubin levels (P = 0.001). The multiple logistic regression analysis showed total bilirubin to be associated with prevalence of DR (P = 0.035).Conclusions:The levels of total bilirubin were significantly lower in patients with DR and also in the late stages of retinopathy as compared to those without retinopathy and in controls but MDA levels did not show any association with DR.

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“…Maitreyess (2011) and Martin-Gallan (2003) has also found that MDA serum level on T2DM with complication was higher than the no complication group [12], [13]. Bhutia (2011) and Jalees (2017) found that the MDA serum level was significantly elevated in patients with diabetes compared to those in normal subjects [14], [15]. Zavar-Reza (2014) observed significant increased MDA serum level in T2DM patients with complications [16].…”

Section: Discussionmentioning

confidence: 99%

The Correlation between Malondialdehyde and Nerve Growth Factor Serum Level with Diabetic Peripheral Neuropathy Score

Decroli

Manaf

Syahbuddin

et al. 2019

Open Access Maced J Med Sci

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AIM:This study was conducted to identify malondialdehyde (MDA) serum level, nerve growth factor (NGF) serum level, diabetic peripheral neuropathy score and the correlation between MDA and NGF serum level with diabetic peripheral neuropathy score.METHODS:A cross-sectional study was conducted to observe diabetic patients in the internal medicine department in Dr M. Djamil Hospital, Padang, Indonesia. The MDA serum level was measured using Beuge method with thiobarbituric acid. The NGF serum level was analysed using ELISA method. Diabetic peripheral neuropathy score was defined when history score in Michigan Neuropathy Screening Instrument (MNSI) ≥ 7 and physical assessment score in MNSI > 2.RESULTS:Thirty subjects with diabetes has diabetic peripheral neuropathy score 3.53 (± 0.91), MDA serum level 2.16 (± 2.89) nmol/ml, and NGF serum level 10.56 (± 2.89) pg/dl. There were significant correlations between the MDA serum level and the diabetic peripheral neuropathy score (r = 0.364, p = 0.048), and between the NGF serum level with the diabetic peripheral neuropathy score (r = -0.59, p = 0.001).CONCLUSION:There are high MDA serum level and low NGF serum level in patients with diabetic peripheral neuropathy. Low NGF serum level plays a bigger role than high MDA serum level in diabetic peripheral neuropathy.

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Serum malondialdehyde level: Surrogate stress marker in the Sikkimese diabetics

Cited by 61 publications

References 23 publications

Poor Glycaemic Control Is Associated with Increased Lipid Peroxidation and Glutathione Peroxidase Activity in Type 2 Diabetes Patients

Poor Glycaemic Control Is Associated with Increased Lipid Peroxidation and Glutathione Peroxidase Activity in Type 2 Diabetes Patients

Association of bilirubin and malondialdehyde levels with retinopathy in type 2 diabetes mellitus

The Correlation between Malondialdehyde and Nerve Growth Factor Serum Level with Diabetic Peripheral Neuropathy Score

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