Serum Mercury Level and Multiple Sclerosis

Attar, Ahmad Movahedian; Kharkhaneh, Azam; Etemadifar, Masoud; Keyhanian, Kiandokht; Davoudi, Vahid; Saadatnia, Mohammad

doi:10.1007/s12011-011-9239-y

Cited by 25 publications

(20 citation statements)

References 31 publications

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“…Low exposure to mercury has been reported to play a role in immune system dysregulation [12, 13] . It may trigger autoimmune diseases such as systemic lupus erythematosus and multiple sclerosis [14–16] . An aberrant immune response resulting in inflammatory bowel disease-like lesions has been associated with mercury intoxication [12] .…”

Section: Discussionmentioning

confidence: 99%

Chronic Mercury Intoxication Masquerading as Systemic Disease: A Case Report and Review of the Literature

Malek¹,

Aouad

Khoury

et al. 2017

European Journal of Case Reports in Internal Medicine

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Background: Mercury is a highly toxic environmental metal that exists in three different forms: elemental, inorganic and organic. Intoxication occurs in either occupational or non-occupational settings, mainly after the inhalation of vapour and fumes in work places, laboratories or homes. Chronic mercury toxicity ranges from mild and insignificant to severe and life-threatening. We describe the case of a young male patient who presented with multiple organ dysfunction after chronic mercury exposure. Case presentation: We report the case of 28-year-old male artisanal gold miner who was admitted to hospital for severe neurological impairment associated with inflammatory bowel disease-like symptoms and a skin rash after mercury exposure. Symptomatic treatment and corticosteroid administration assured rapid clinical improvement. Chronic mercury poisoning can masquerade as an autoimmune or systemic inflammatory disease. Conclusion: Physicians should be aware that low exposure to mercury, even from artisanal gold mining, may be harmful to health. Management can be simple without the need for aggressive or invasive therapeutic measures. Larger case series are required in order to establish a clear management plan. LEARNING POINTS• Mercury intoxication has a wide the variety of clinical manifestations that may involve the neurological, gastrointestinal and dermatological systems. • Therefore, it can mimic degenerative neurological conditions, autoimmune diseases, as well as metabolic and mitochondrial disorders.• Once diagnosed, mercury intoxication is easily treated.

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Section: Discussionmentioning

confidence: 99%

Chronic Mercury Intoxication Masquerading as Systemic Disease: A Case Report and Review of the Literature

Malek¹,

Aouad

Khoury

et al. 2017

European Journal of Case Reports in Internal Medicine

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“…No environmental pollutant or toxicants have been investigated in CD, although environmental pollution is getting higher and higher in the last decades. Different studies demonstrated that Hg participates in the development of several immune disorders as membraneous nephropathy [ 43 ], autoimmune glomerulonephritis [ 44 ], Wegener's granulomatosis [ 45 ], scleroderma [ 46 ], systemic lupus erythematosus [ 47 ], pemphigus [ 48 ], and multiple sclerosis [ 49 ]. Epidemiologic data suggest that Hg amalgam fillings have an effect in the exacerbation and/or onset of multiple sclerosis [ 47 ].…”

Section: Discussionmentioning

confidence: 99%

Increased Mercury Levels in Patients with Celiac Disease following a Gluten-Free Regimen

Elli

Rossi

Conte

et al. 2015

Gastroenterology Research and Practice

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Background and Aim. Although mercury is involved in several immunological diseases, nothing is known about its implication in celiac disease. Our aim was to evaluate blood and urinary levels of mercury in celiac patients. Methods. We prospectively enrolled 30 celiac patients (20 treated with normal duodenal mucosa and 10 untreated with duodenal atrophy) and 20 healthy controls from the same geographic area. Blood and urinary mercury concentrations were measured by means of flow injection inductively coupled plasma mass spectrometry. Enrolled patients underwent dental chart for amalgam fillings and completed a food-frequency questionnaire to evaluate diet and fish intake. Results. Mercury blood/urinary levels were 2.4 ± 2.3/1.0 ± 1.4, 10.2 ± 6.7/2.2 ± 3.0 and 3.7 ± 2.7/1.3 ± 1.2 in untreated CD, treated CD, and healthy controls, respectively. Resulting mercury levels were significantly higher in celiac patients following a gluten-free diet. No differences were found regarding fish intake and number of amalgam fillings. No demographic or clinical data were significantly associated with mercury levels in biologic samples. Conclusion. Data demonstrate a fourfold increase of mercury blood levels in celiac patients following a gluten-free diet. Further studies are needed to clarify its role in celiac mechanism.

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“…Literature data concerning metal alterations in MS patients are partly contradictory and may depend on the biological specimens used for analysis (such as blood, serum, hair, urine, CSF, or post-mortem tissues from autopsy) making comparisons between studies of limited values. Several studies using atomic absorption spectrophotometry, the colorimetric method, or neutron activation analysis have reported altered metal levels in blood or serum from MS patients, such as decreased levels of zinc [132][133][134], increased levels of copper [135,136], increased levels of arsenic and lead [137,138], and increased levels of mercury [139] compared to healthy control groups.…”

Section: Metals In the Blood Or Serummentioning

confidence: 99%

Metal Imbalance in Neurodegenerative Diseases with a Specific Concern to the Brain of Multiple Sclerosis Patients

Dalès

Desplat‐Jégo

2020

IJMS

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There is increasing evidence that deregulation of metals contributes to a vast range of neurodegenerative diseases including multiple sclerosis (MS). MS is a chronic inflammatory disease of the central nervous system (CNS) manifesting disability and neurological symptoms. The precise origin of MS is unknown, but the disease is characterized by focal inflammatory lesions in the CNS associated with an autoimmune reaction against myelin. The treatment of this disease has mainly been based on the prescription of immunosuppressive and immune-modulating agents. However, the rate of progressive disability and early mortality is still worrisome. Metals may represent new diagnostic and predictive markers of severity and disability as well as innovative candidate drug targets for future therapies. In this review, we describe the recent advances in our understanding on the role of metals in brain disorders of neurodegenerative diseases and MS patients.

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Serum Mercury Level and Multiple Sclerosis

Cited by 25 publications

References 31 publications

Chronic Mercury Intoxication Masquerading as Systemic Disease: A Case Report and Review of the Literature

Chronic Mercury Intoxication Masquerading as Systemic Disease: A Case Report and Review of the Literature

Increased Mercury Levels in Patients with Celiac Disease following a Gluten-Free Regimen

Metal Imbalance in Neurodegenerative Diseases with a Specific Concern to the Brain of Multiple Sclerosis Patients

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