Serum microRNA expression profiling in patients with multiple system atrophy

Kume, Kodai; Iwama, Hisakazu; Deguchi, Kazushi; Ikeda, Kazuyo; Takata, Tadayuki; Kokudo, Yasutaka; Kamada, Masaki; Fujikawa, Keiko; Hirose, Kenichi; Masugata, Hisashi; Touge, Tetsuo; Masaki, Tsutomu

doi:10.3892/mmr.2017.7995

Cited by 25 publications

(23 citation statements)

References 33 publications

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“…Kume and colleagues investigated serum of 10 MSA patients and 6 controls. Microarray analysis showed the up-regulation of 50 miRNAs in MSA patients, whereas 17 miRNAs were significantly decreased ( Kume et al, 2017 ). Again, miR-223, and miR-24 were found to be up-regulated, but qRT-PCR validation of the most regulated miRNAs (miR-223 and miR-16) showed negative results.…”

Section: Circulating Mirnas As Biomarkers In Other Parkinsonian Syndrmentioning

confidence: 99%

Circulating miRNAs as Diagnostic Biomarkers for Parkinson’s Disease

et al. 2018

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Parkinson’s disease (PD) is the second most common neurodegenerative disorder worldwide. Its main neuropathological hallmarks are the degeneration of dopaminergic neurons in the substantia nigra and alpha-synuclein containing protein inclusions, called Lewy Bodies. The diagnosis of idiopathic PD is still based on the assessment of clinical criteria, leading to an insufficient diagnostic accuracy. Additionally, there is no biomarker available allowing the prediction of the disease course or monitoring the response to therapeutic approaches. So far, protein biomarker candidates such as alpha-synuclein have failed to improve diagnosis of PD. Circulating microRNAs (miRNAs) in body fluids are promising biomarker candidates for PD, as they are easily accessible by non- or minimally-invasive procedures and changes in their expression are associated with pathophysiological processes relevant for PD. Advances in miRNA analysis methods resulted in numerous recent publications on miRNAs as putative biomarkers. Here, we discuss the applicability of different body fluids as sources for miRNA biomarkers, highlight technical aspects of miRNA analysis and give an overview on published studies investigating circulating miRNAs as biomarker candidates for diagnosis of PD and other Parkinsonian syndromes.

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Section: Circulating Mirnas As Biomarkers In Other Parkinsonian Syndrmentioning

confidence: 99%

Circulating miRNAs as Diagnostic Biomarkers for Parkinson’s Disease

et al. 2018

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“…Recently, the obvious change of several miRNAs with high expression in muscle has been identified and detected in plasma and serum during the process of muscle disorders [ 54 ]. Serum miRNAs may come from the active secretion process of histiocytes, while mature miRNAs are coated with lipids or lipoproteins to form exosomes and secrete into blood.…”

Section: Mirna and Muscle Atrophymentioning

confidence: 99%

Regulatory Role of MicroRNAs in Muscle Atrophy during Exercise Intervention

Zhang

Chen

2018

IJMS

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Skeletal muscle comprising approximately 40% of body weight is highly important for locomotion and metabolic homeostasis. The growth and regeneration of skeletal muscle are highly organized processes; thus, it is not surprising to reveal certain complexity during these regulatory processes. Recently, a large number of evidence indicate that microRNAs can result in obvious impacts on growth, regeneration and metabolism of skeletal muscle. In this review, recent research achievements of microRNAs in regulating myogenesis, atrophy and aging during exercise intervention are discussed, which will provide the guidance for developing potential applications of microRNAs in health promotion and rehabilitation of sports injuries.

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“…The level of miR-24 expression is dysregulated in the serum of patients with MSA [202,203]. Interestingly, miR-24 binds to the 3 -UTR of Per2 and plays an important post-transcriptional regulatory role in the PER2 expression required for normal circadian timekeeping, as described above.…”

Section: Multiple System Atrophymentioning

confidence: 80%

MicroRNA: A Key Player for the Interplay of Circadian Rhythm Abnormalities, Sleep Disorders and Neurodegenerative Diseases

et al. 2020

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Circadian rhythms are endogenous 24-h oscillators that regulate the sleep/wake cycles and the timing of biological systems to optimize physiology and behavior for the environmental day/night cycles. The systems are basically generated by transcription–translation feedback loops combined with post-transcriptional and post-translational modification. Recently, evidence is emerging that additional non-coding RNA-based mechanisms are also required to maintain proper clock function. MicroRNA is an especially important factor that plays critical roles in regulating circadian rhythm as well as many other physiological functions. Circadian misalignment not only disturbs the sleep/wake cycle and rhythmic physiological activity but also contributes to the development of various diseases, such as sleep disorders and neurodegenerative diseases. The patient with neurodegenerative diseases often experiences profound disruptions in their circadian rhythms and/or sleep/wake cycles. In addition, a growing body of recent evidence implicates sleep disorders as an early symptom of neurodegenerative diseases, and also suggests that abnormalities in the circadian system lead to the onset and expression of neurodegenerative diseases. The genetic mutations which cause the pathogenesis of familial neurodegenerative diseases have been well studied; however, with the exception of Huntington’s disease, the majority of neurodegenerative diseases are sporadic. Interestingly, the dysfunction of microRNA is increasingly recognized as a cause of sporadic neurodegenerative diseases through the deregulated genes related to the pathogenesis of neurodegenerative disease, some of which are the causative genes of familial neurodegenerative diseases. Here we review the interplay of circadian rhythm disruption, sleep disorders and neurodegenerative disease, and its relation to microRNA, a key regulator of cellular processes.

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Serum microRNA expression profiling in patients with multiple system atrophy

Cited by 25 publications

References 33 publications

Circulating miRNAs as Diagnostic Biomarkers for Parkinson’s Disease

Circulating miRNAs as Diagnostic Biomarkers for Parkinson’s Disease

Regulatory Role of MicroRNAs in Muscle Atrophy during Exercise Intervention

MicroRNA: A Key Player for the Interplay of Circadian Rhythm Abnormalities, Sleep Disorders and Neurodegenerative Diseases

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