Serum miR‐19a expression correlates with worse prognosis of patients with non‐small cell lung cancer

Abstract

High serum miR-19a expression may be an independent poor prognostic factor for survival in NSCLC patients.

MicroRNA-19 triggers epithelial–mesenchymal transition of lung cancer cells accompanied by growth inhibition

“…42,[49][50][51][52][53][54][55][56][57] In addition, miR-19 upregulation was observed in various cancers including lung cancer, and correlated with tumor metastasis and/or poor prognosis of cancer patients. [11][12][13][14][15]18 Given that miRNAs primarily function through inhibiting the translation of their mRNA targets, we propose that miR-19 might be a negative regulator for PTEN, which has been reported by other researchers. 10,29,58,59 In addition, miR-19 increased the resistance to apoptosis of mouse B-cell lymphoma, 10,29 and chemoresistance of human breast cancer 58 and gastric cancer 59 through directly repressing PTEN expression.…”

“…It has been reported that miR-19 was dysregulated in various cancers, and miR-19 upregulation strongly correlated with gain of invasive and metastatic properties and poor prognosis of patients with NSCLC, [11][12][13] gastric cancer, 14 and esophageal squamous cell carcinoma. 15 Moreover, the expression of miR-19 was significantly higher in the lessinvasive breast cancer MCF7 cells than the more-invasive MDAMB-231 cells, and the expression of a positive regulator of tumor angiogenesis and metastasis was negatively regulated by miR-19 in breast cancer cells, 35 suggesting that miR-19 inhibited the metastasis of breast cancer.…”

“…Previous studies have also reported that upregulation of miR-19a and miR-19b-1 was associated with cancer invasion and metastasis, and poor prognosis of patients with early non-small-cell lung carcinoma (NSCLC), [11][12][13] gastric cancer, 14 and esophageal squamous cell carcinoma. 15 In addition, high levels of serum miR-19a and miR-19b-1 were considered as independent prognostic factors for poor survival of NSCLC patients.…”

“…15 In addition, high levels of serum miR-19a and miR-19b-1 were considered as independent prognostic factors for poor survival of NSCLC patients. 12,13 In a mouse model of c-Myc-driven B-cell lymphomas, Em-myc/miR-19b-1 lymphomas are highly invasive as lymphoma cells invaded the thymus and bone marrow, as well as visceral organs outside the lymphoid compartment, including the liver, lung, and, occasionally, the kidney. 10 More recent studies have reported that miR-19a or miR-19b-1 promoted the migration and invasion of cervical carcinoma cells, 16 colon cancer cells, 17 and gastric cancer cells through targeting the tumor suppressor MXD1, 14 and Hela, MCF7, and Huh7 cells through targeting TP53.…”

“…Given that miR-19 is associated with cancer invasion and metastasis and EMT is the central mechanism underlying cancer invasion and metastasis, [10][11][12][13][14][15][16][17][18] the present study aimed to investigate whether miR-19 is able to induce EMT and enhance invasion and metastasis of human cancer cells. Our results showed that enforced expression of miR-19 in lung cancer cells induced EMT, which caused growth inhibition but elevated migration of the cancer cells.…”