Serum Neuron-Specific Enolase, Biogenic Amino-Acids and Neurobehavioral Function in Lead-Exposed Workers from Lead-Acid Battery Manufacturing Process

Kalahasthi, Ravibabu; Barman, Tapu; Rajmohan, HR

doi:10.15171/ijoem.2015.436

Cited by 10 publications

(6 citation statements)

References 31 publications

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“…In this study, no significant relationship was observed between age and blood lead and this could be attributed to the younger age of the studied subjects. However, in the study of Ravibabu et al, a significant relationship was found between age and serum levels (14). The present investigations showed a positive correlation between blood lead levels and years of employment and also a lower score of the Benton Visual Test.…”

Section: Discussioncontrasting

confidence: 51%

The Relationship Between Serum Lead Level and Neurobehavioral Performance

2019

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Background: Lead is one of the metals, which has an important role in the industry. Objectives: We designed a study to assess the serum lead level in battery manufacturing workers and its association with neurobehavioral performance. Methods: In this cross-sectional, 154 individuals who worked in a battery factory participated. Venous blood samples were collected for measuring blood lead levels by atomic absorption method. Three selected tests of neuropsychological performance approved by World Health Organization were conducted, including simple reaction time (SRT), Benton Visual Retention Test (BVRT), and Santa Ana manual dexterity test. Results: The present study demonstrates a positive correlation between blood lead levels and work experience. The higher blood lead levels and longer work experience were associated with lower scores on the Benton Visual Test. Simple reaction time showed a significant relationship with the work experience. Conclusions:The results of this study suggest that occupational exposure to lead can induce a neurobehavioral dysfunction in battery manufacturing workers. Thus neurobehavioral assessment in health surveillance of exposed workers can be effective in the early detection of cognitive impairment.

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Section: Discussioncontrasting

confidence: 51%

The Relationship Between Serum Lead Level and Neurobehavioral Performance

2019

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“…It has highly toxic effects on all mammals. Many reports have shown the toxic effects of lead on bone, hematopoiesis, and renal function, and on the digestive, immune and nervous systems (Gurer-Orhan et al 2004;Ekong et al 2006;Ravibabu et al 2015). Additionally, lead preferentially accumulates in male reproductive organs and leads to adverse effects on the male reproductive system (Benoff et al 2000).…”

Section: Introductionmentioning

confidence: 99%

Lead Inhibits Human Sperm Functions by Reducing the Levels of Intracellular Calcium, cAMP, and Tyrosine Phosphorylation

Zou

Chen

et al. 2016

Tohoku J. Exp. Med.

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It is well known that there has been a worldwide decrease in human male fertility in recent years. One of the main factors affecting this is environmental pollution. Lead is one of the major heavy metal contaminants that threaten the health of animals and human beings in China. It preferentially accumulates in male reproductive organs and can be up to 10 µM in human seminal plasma. Lead impairs mammalian spermatogenesis and sperm quality in vivo. It also inhibits sperm functions in vitro but the underlying mechanisms remain unclear. Therefore, we aimed to investigate the in vitro toxicity of lead on human sperm functions and to elucidate the underlying mechanisms. Semen samples were collected from 20 healthy volunteers with different careers and backgrounds living in Nanchang, Jiangxi. Human sperm suspensions were treated with different concentrations of lead acetate (0, 0.5, 2.5, 10, 50, and 100 µM) and the viability, motility, capacitation and progesterone-induced acrosome reaction were examined. Treatment with 10-100 µ M lead acetate dose-dependently inhibited total and progressive motility measures, capacitation and progesterone-induced acrosome reaction. It also dose-dependently decreased the intracellular concentrations of cyclic adenosine monophosphate (cAMP) and calcium ([Ca 2+ ] i ), and reduced the tyrosine phosphorylation of sperm proteins, all of which are thought to be key factors in the regulation of sperm function. Our findings suggest that lead inhibits human sperm functions by reducing the levels of sperm intracellular cAMP, [Ca 2+ ] i and tyrosine phosphorylation of sperm proteins in vitro.

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“… 1 Occupational exposure to lead occurs through inhalation and ingestion. Recent studies on lead-battery manufacturing workers have reported high musculoskeletal disorders with markers of inflammation, 2 mucocutaneous changes, 3 oxidative stress, 4 altered serum magnesium fractions, 5 elevated blood lead levels (BLLs), 6 , 7 reticulocytosis, 8 altered genetic polymorphisms of δ-aminolevulinic acid dehydratase (ALAD), 9 impaired biogenic amino acids with neurobehavioral function, 10 genotoxicity, 11 impaired coagulation function, 12 health problems, 13 , 14 male reproductive function, 15 ocular changes, 16 impaired hematological parameters, 17 and altered calcium metabolism by inhibiting the kidney 1-𝛼-hydroxylase enzyme, which is required for 1, 25 dihydroxy-vitamin D 3 synthesis 18 .…”

Section: Introductionmentioning

confidence: 99%

Assessment of Bone Turnover Biomarkers in Lead-Battery Workers with Long-Term Exposure to Lead

Kalahasthi

Barman

Bagepally

2020

Int J Occup Environ Med

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Background: The major portion of lead in the body resides in skeletal system. The bone turnover affects the release of lead into the circulation from bones. The bone turnover biomarkers (BTM) in lead-battery workers with long-term exposure to lead have not been explored yet. Objective: To evaluate the BTM (formation and resorption) in lead-battery workers with long-term exposure to lead in lead-battery manufacturing plant. Methods: 176 male lead-exposed workers and 80 matched comparison group were studied. All participants were examined for blood lead levels (BLLs), bone formation biomarkers—serum osteocalcin (OC), alkaline phosphatase (ALP), bone-specific alkaline phosphatase (BALP)—and bone resorption biomarkers—serum pyridinoline (PYD), deoxypyridinoline (DPYD), tartarate-resistant acid phosphatase-5b (TRACP-5b), and urinary hydroxyproline (UHYP). Results: We found a significantly higher bone formation biomarkers such as BALP (p=0.007) and bone resorption biomarkers, eg, PYD (p=0.048), TRCAP-5b (p=0.001), and UHYP (p=0.001) in lead-exposed workers. A significant (p=0.041) negative correlation (ρ -0.128) was noted between BLLs and OC. A significant positive correlation was noted between BLLs and TRACP-5b (ρ 0.176, p=0.005) and UHYP (ρ 0.258, p=0.004). Serum OC (p=0.040) and UHYP (p=0.015) levels changed significantly with BLL level. Bone resorption biomarkers levels—PYD, TRACP-5b, and BALP—were higher among those with higher BLLs levels. The duration of exposure was significantly associated with BALP (p=0.037), DPYD (p=0.016), TRACP5b (p=0.001), and UHYP (p=0.002) levels. Conclusion: Long-term lead exposure affects the bone turnover.

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Serum Neuron-Specific Enolase, Biogenic Amino-Acids and Neurobehavioral Function in Lead-Exposed Workers from Lead-Acid Battery Manufacturing Process

Abstract: Serum NSE cannot be used as a marker for BLL. The only domain of neurobehavioral function tests that is affected by increased BLL in workers of lead-acid battery manufacturing process is that of the "attention and perception" (SDST).

Cited by 10 publications

References 31 publications

The Relationship Between Serum Lead Level and Neurobehavioral Performance

The Relationship Between Serum Lead Level and Neurobehavioral Performance

Lead Inhibits Human Sperm Functions by Reducing the Levels of Intracellular Calcium, cAMP, and Tyrosine Phosphorylation

Assessment of Bone Turnover Biomarkers in Lead-Battery Workers with Long-Term Exposure to Lead

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