Serum Omentin 1 Level Is Associated With Coronary Artery Disease and Its Severity in Postmenopausal Women

Onur, Imran; Öz, Fahrettin; Yıldız, Süleyman Sezai; Oflaz, Hüseyin; Sığırcı, Serhat; Elıtok, Ali; Pilten, Saadet; Karaayvaz, Ekrem Bilal; Çizgici, Ahmet Yaşar; Kaya, Mehmet; Önür, Seda Tural; Şahin, İrfan; Dinçkal, Hakan

doi:10.1177/0003319713511322

Cited by 42 publications

(24 citation statements)

References 18 publications

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“…In postmenopausal women who had undergone coronary angiography, patients with angiographic CAD had significantly decreased omentin-1 levels, compared to those without CAD (ref. 7 ). Similarly, older males, mean age 63 years with CAD had markedly lower plasma levels of omentin-1 than control subjects 8 .…”

Section: Discussionmentioning

confidence: 99%

“…Omentin-1 is also an adipokine with anti-inflammatory effects that has been associated with different metabolic disorders 6 . Recent studies have shown that omentin-1 values were decreased in older men and women with coronary artery disease 7,8 . However, the role of omentin-1 in the pathophysiology of coronary artery disease and its early manifestation in younger people is not well defined.…”

Section: Introductionmentioning

confidence: 99%

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Omentin-1 levels in patients with premature coronary artery disease, metabolic syndrome and healthy controls. Short communication

Stejskal

Václavík

Smékal

et al. 2016

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub

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Objectives. Omentin-1 is an adipokine which could have a protective role against the manifestation of atherosclerosis. Only limited data are available on omentin-1 serum values in patients with premature clinical manifestations of atherosclerosis.Design and Methods. We tested omentin-1 in human serum by ELISA method in 61 individuals with a premature manifestation of coronary artery disease (CAD), 40 patients with metabolic syndrome and 40 healthy control subjects. Results. Omentin-1 serum levels were significantly lower in patients with CAD (103.1±62.7 mg/L) compared to metabolic syndrome (668.2±339.6 mg/L) and healthy subjects (623.0±373.5 mg/L) (P < 0.01). In CAD patients, omentin-1 serum levels did not differ between patients sampled in the acute phase of myocardial infarction (n = 28; 110.3±82.4 mg/L) and in the chronic phase several months or years after myocardial infarction (n = 33; 97.0±39.3 mg/L) (P = 0.41). We found a weak positive correlation between omentin-1 and body mass index (r = 0.21, P = 0.014). No significant correlation was found between peak cardiac troponin T and omentin-1 (correlation coefficient r = 0.118, P = 0.406). Conclusion. Serum omentin-1 seems to be a useful biomarker of coronary artery disease across the whole age spectrum.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Omentin-1 levels in patients with premature coronary artery disease, metabolic syndrome and healthy controls. Short communication

Stejskal

Václavík

Smékal

et al. 2016

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub

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“…Several cross-sectional studies further reported that omentin levels are inversely associated with insulin resistance (assessed as homeostasis model assessmentestimated insulin resistance (HOMA-IR)) (7, 8,11,12,13,14) and decreased in individuals with impaired fasting glucose (IFG), impaired glucose tolerance (IGT), or type 2 diabetes (8,11,12,14,15,16). Such an inverse association may be explained by the anti-inflammatory properties of omentin that have been observed in in vitro studies on endothelial cells and smooth muscle cells (17,18,19).…”

Section: Introductionmentioning

confidence: 99%

Adiponectin may mediate the association between omentin, circulating lipids and insulin sensitivity: results from the KORA F4 study

Herder

Ouwens

Carstensen

et al. 2015

European Journal of Endocrinology

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Objective: Reduced circulating omentin levels have been reported in obesity and type 2 diabetes, but data were mostly derived from univariate analyses in small study samples. This study aimed to investigate the relationship between omentin, abnormal glucose tolerance and related metabolic factors in a large population-based cross-sectional study. Design and methods: Serum omentin was measured by ELISA in 1092 participants of the German KORA F4 survey (2006)(2007)(2008). Associations between omentin serum levels, glucose tolerance (assessed with an oral glucose tolerance test) and diabetesrelated factors were estimated using logistic and linear regression models respectively. Results: Serum levels of omentin were not related to categories of glucose tolerance. However, serum omentin was positively associated with whole-body insulin sensitivity index (ISI (composite)) and HDL cholesterol and showed inverse associations with 2-h post-load glucose, fasting insulin, homeostasis model assessment-estimated insulin resistance, BMI and triglycerides (all P%0.03 after adjustment for age, sex and lifestyle factors). Further adjustment for BMI and/or serum lipids attenuated the associations with parameters of glucose metabolism, whereas adjustment for serum adiponectin virtually abolished all aforementioned associations. In contrast, adjustment for omentin had no effect on the positive association between adiponectin levels and ISI (composite). Conclusions: The data from this large population-based cohort show that circulating omentin levels are associated with insulin sensitivity. Our observations further suggest that omentin acts via upregulation of adiponectin, which in turn affects lipid metabolism and thereby also indirectly enhances insulin sensitivity, but mechanistic studies are required to corroborate this hypothesis.

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“…Fstl1 promotes differenwomen. 39 Low levels of circulating omentin are also observed in patients with acute MI. 40 In addition, omentin levels inversely correlate with carotid intima-media thickness, which is a marker for atherosclerosis.…”

Section: Myokines With Cardiovascular Protective Propertiesmentioning

confidence: 99%

Protective Roles of Adipocytokines and Myokines in Cardiovascular Disease

Ouchi

Ohashi

Shibata

et al. 2016

Circ J

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Obesity is a major risk factor for progression of cardiovascular disease. Adipose tissue is recognized as an endocrine organ producing various secretory molecules, also known as adipocytokines, and dysregulated production of adipocytokines participates in the pathogenesis of obesity complications, including metabolic dysfunction and cardiovascular disorders. Recent evidence indicates that skeletal muscle also functions as an endocrine organ capable of secreting a number of bioactive substances, also referred to as myokines. Several myokines are involved in metabolic and cardiovascular regulation. This review will discuss the clinical and experimental studies that have investigated the protective role of several adipocytokines and myokines in cardiovascular diseases. (Circ J 2016; 80: 2073 -2080

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Serum Omentin 1 Level Is Associated With Coronary Artery Disease and Its Severity in Postmenopausal Women

Cited by 42 publications

References 18 publications

Omentin-1 levels in patients with premature coronary artery disease, metabolic syndrome and healthy controls. Short communication

Omentin-1 levels in patients with premature coronary artery disease, metabolic syndrome and healthy controls. Short communication

Adiponectin may mediate the association between omentin, circulating lipids and insulin sensitivity: results from the KORA F4 study

Protective Roles of Adipocytokines and Myokines in Cardiovascular Disease

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