Serum Oxidized Protein and Prostate Cancer Risk within the Prostate Cancer Prevention Trial

Hoque, Ashraful; Ambrosone, Christine B.; Till, Cathee; Goodman, Phyllis J.; Tangen, Cathy; Kristal, Alan R.; Lucia, Scott; Wang, Qiao; Kappil, Maya; Thompson, Ian M.; Hsing, Ann W.; Parnes, Howard L.; Santella, Regina M.

doi:10.1158/1940-6207.capr-09-0201

Cited by 12 publications

(10 citation statements)

References 20 publications

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“…Sample sizes ranged from 15 to 3,163. 31 , 32 The mean age of participants ranged from 60 years to 74 years. Twenty-three studies were conducted using a case control study design, 19 were case control studies, two were prospective, one was nested, and one was a subset of the Nashville Men's Health study.…”

Section: Resultsmentioning

confidence: 99%

Oxidative stress in prostate cancer patients: A systematic review of case control studies

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Costa

et al. 2016

Prostate International

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BackgroundProstate cancer (PCa) is the most common cancer in men in Western countries. In-vitro and in-vivo studies suggest that oxidative stress (OS) and antioxidants play a key role in the pathogenesis of chronic diseases including PCa, which is promoted by the production of reactive oxygen species and impaired antioxidant defense mechanisms. This study evaluates the association between OS and men with PCa.MethodsA literature search was carried out on Medline, PubMed, and ScienceDirect databases, as well as manual searches from inception up to August 2015 using the keywords “Oxidative stress” or “Reactive oxygen species” or “Lipid peroxidation” AND “Prostate cancer.” All studies including data on the measurement of OS biomarkers in PCa were included.ResultsTwenty-three case control studies were retrieved with sample sizes ranging from 15 to 3,613 (6,439 participants in total). Markers of OS were significantly higher in patients with PCa compared with control groups in 21 studies. Two self-controlled case studies comparing OS between PCa cells and non-PCa cells in tissue biopsies found OS to be statistically higher in PCa cancer cells. Results on markers of antioxidant capacity (superoxide dismutase, catalase, glutathione, glutathione reductase, glutathione peroxidase, uric acid, lutein, lycopene, beta carotein, vitamin A, vitamin C, vitamin E, and total antioxidants) were not completely consistent in their association with PCa.ConclusionsUpregulated OS profiles and impairment of antioxidant defense systems may play a role in men with PCa. To confirm these findings, robust clinical trials utilizing a personalized approach which monitors both OS and antioxidant markers during therapy are warranted.

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Section: Resultsmentioning

confidence: 99%

Oxidative stress in prostate cancer patients: A systematic review of case control studies

Figtree

Costa

et al. 2016

Prostate International

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“…As a consequence, by the TNF-α/AP-1 transduction pathway and the NF-κB-Inducing Kinase (NIK) transduction pathway, the local production of proinflammatory cytokines [34] is determined by triggering apoptotic pathway which limits uncontrolled cell proliferation. In this regard, TR10/P3795 exerted a significant reduction of MDA and inflammatory markers unlike finasteride which had already been demonstrated not to affect protein oxidation in the prostate [35]. This is likely to be advocated for by the total phenolic content of a selected extract from pumpkin in its composition.…”

Section: Discussionmentioning

confidence: 86%

Beneficial Effect of a Multifunctional Polyphytocompound in Experimental Prostatic Hyperplasia in Rats

Kantah¹,

Singh²,

Sweed³

et al. 2017

Clin Pharmacol Biopharm

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The aim of the present study was to assess the efficacy of a poly-phytocompound in a model of experimental BPH. Adult 8 weeks male Wistar rats were subjected to complete orchiectomy under anesthesia (i.p. injection of 100 mg/kg body weight of sodium pentobarbital). After castration, experimental BPH was reproduced by subcutaneous injection of testosterone (20 mg/kg) for 4 weeks and, at the same time, rats randomly divided in 3 groups (15 rats each): (A) untreated BPH model; (B) BPH plus TR10/P3795 orally and (C) BPH plus finasteride (10 mg/kg body weight) administered orally as positive control group. A third group (D) of sham-operated rats served as control. Both TR10/P3795-and finasteride-treated groups showed a significant (p<0.05) and comparable reduction of all morphometric parameters (volume, weight and weight/body weight ration) which were grossly abnormal in untreated BPH model (p<0.01 vs. sham-op.). Moreover, both treatment schedule maintained a near-to-normal 3 h urinary output (p<0.01 vs. untreated BPH). Untreated BPH showed a significant increase of epithelial size and thickness and these features were equally decreased by TR10/P3795 and finasteride (p<0.05). Either TR10/P3795 or finasteride brought about a significant decrease of serum level of DHT and PAP (p<0.05 vs. sham). There was no difference among the two treatments. Prostatic tissue concentration of MDA, IL-6, TNFα and TGFβ1 significantly increased in untreated BPH model (p<0.001). All these parameters significantly decreased, although not normalised, in TR10/P3795-treated group (p<0.05 vs. sham and vs. finasteride). Finasteride determined only a not significant trend decrease of IL-6 and TNFα. Given the multifactorial aetiology of BPH, the data from this experimental model show the promising larger spectrum of mechanisms of action of the tested poly-phytocompound.

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“…In addition, the protein carbonyl levels in tissue were significantly higher in HGPIN than those in malign Ca. Some studies have provided conflicting evidence on the association between protein oxidation and cancer risk, with positive results for Hodgkin's lymphoma and bladder cancer, but not for lung or brain cancer [41]. However, Hoque et al [41] showed that there were no significant differences in protein carbonyl levels in basaline samples between those later diagnosed with prostate cancer and those without at the end of study biopsy.…”

Section: Discussionmentioning

confidence: 99%

“…Some studies have provided conflicting evidence on the association between protein oxidation and cancer risk, with positive results for Hodgkin's lymphoma and bladder cancer, but not for lung or brain cancer [41]. However, Hoque et al [41] showed that there were no significant differences in protein carbonyl levels in basaline samples between those later diagnosed with prostate cancer and those without at the end of study biopsy. Neither was there a significant association between protein carbonyl level and risk when analyzing high-grade and low-grade disease separately, nor did finasteride affect protein oxidation levels.…”

Section: Discussionmentioning

confidence: 99%

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Association of Pb, Cd, and Se Concentrations and Oxidative Damage-Related Markers in Different Grades of Prostate Carcinoma

Güzel

Kiziler

Aydemir

et al. 2011

Biol Trace Elem Res

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Prostate cancer is known to be affected by the heavy metal levels and oxidative damage of the body, yet there are very few studies which look into the way it occurs. The aim of this study was to determine whether blood and tissue lead (Pb), cadmium (Cd), and selenium (Se) levels are associated with oxidative damage in the context of prostate cancer progression and development. Seventy-nine patients comprising 25 patients with benign prostatic hypertrophy (BPH), 23 patients with malignant prostatic carcinoma (malign Ca), 16 patients with low-grade prostatic intraepithelial neoplasia (LGPIN), and 15 patients with high-grade prostatic intraepithelial neoplasia (HGPIN) diagnosed on the basis of their clinical profile, transrectal ultrasonography, and histopathology were included in this study. Cd and Pb levels in whole blood were found to be increased in patients with HGPIN compared with the BPH group; also, the levels of Cd in whole blood and tissue were found to be increasing in patients with malign Ca, unlike BPH patients. Moreover, the levels of malondialdehyde (MDA) in plasma and tissue were significantly increased in malign Ca, LGPIN, and HGPIN than those in BPH. However, the levels of tissue Pb were found to be decreasing in BPH, unlike the malign Ca and HGPIN patients, and the levels of tissue protein carbonyls in malign Ca were significantly lower than those in HGPIN. The levels of tissue reduced glutathione (GSH) in malign Ca were significantly lower than those in BPH. Additionally, the levels of Se in serum and tissue in LGPIN were significantly lower than those in BPH. The serum Se levels in HGPIN were also significantly lower than those in BPH and malign Ca groups. Furthermore, the concentrations of serum Se in LGPIN were significantly lower than those in malign Ca. From the Pearson correlation analysis, there were significant positive correlations between tissue Cd and MDA levels in malign Ca, LGPIN, and HGPIN and between the tissue Pb and tissue MDA and protein carbonyl levels in malign Ca. Blood Pb and tissue Pb were also significantly positively correlated with plasma MDA and protein carbonyl levels in malign Ca. In addition, blood Pb was significantly positively correlated with tissue MDA and protein carbonyl levels in malign Ca, and a significant positive correlation was also found between blood Cd and plasma protein carbonyls and tissue MDA in LGPIN. We observed that altered prooxidant-antioxidant balance and heavy metal levels may lead to an increase in oxidative damage and may consequently play an important role in prostate carcinogenesis. These findings indicate that changes in the levels of Pb, Cd, Se, MDA, protein carbonyls, and GSH in the blood and/or tissue are related to the prostatic carcinoma development and progression, although triggering one of the mentioned changes is unknown; therefore, further study is required to determine the exact steps of the process and clarify the roles of different substances in order to obtain a more detailed explanation of the phenomenon.

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Serum Oxidized Protein and Prostate Cancer Risk within the Prostate Cancer Prevention Trial

Cited by 12 publications

References 20 publications

Oxidative stress in prostate cancer patients: A systematic review of case control studies

Oxidative stress in prostate cancer patients: A systematic review of case control studies

Beneficial Effect of a Multifunctional Polyphytocompound in Experimental Prostatic Hyperplasia in Rats

Association of Pb, Cd, and Se Concentrations and Oxidative Damage-Related Markers in Different Grades of Prostate Carcinoma

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