Serum paraoxonase and arylesterase activities in metabolic syndrome in Zahedan, southeast Iran

Hashemi, Mohammad; Kordi-Tamandani, Dor Mohammad; Sharifi, Nooshin; Moazeni‐Roodi, Abdolkarim; Kaykhaei, Mahmoud Ali; Narouie, Behzad; Torkmanzehi, Adam

doi:10.1530/eje-10-0881

Cited by 21 publications

(17 citation statements)

References 26 publications

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“…Ethical approvals for recruitment were obtained from local Ethics Committee of Zahedan University of Medical Sciences, and informed consent was obtained from all individuals. The data included weight, height, waist circumference, systolic and diastolic blood pressure; blood levels of glucose, triglycerides, total cholesterol, HDL cholesterol and LDL cholesterol were collected as described previously [23-25]. Blood samples were collected in EDTA-containing tubes and genomic DNA were extracted using salting out method as described previously [26].…”

Section: Methodsmentioning

confidence: 99%

A 45-bp insertion/deletion polymorphism of UCP2 gene is associated with metabolic syndrome

Hashemi

Rezaei

Kaykhaei

et al. 2014

J Diabetes Metab Disord

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BackgroundMetabolic syndrome (MeS) is being recognized as a risk factor for insulin resistance and cardiovascular disease. The present study was aimed to find out the possible association between 45-bp I/D polymorphism of uncoupling protein 2 (UCP2) and MeS.MethodsDNA was extracted from peripheral blood of 151 subjects with and 149 subjects without MeS. 45-bp I/D variant of UCP2 was detected using polymerase chain reaction (PCR).ResultsOur finding showed that 45-bp I/D polymorphism was associated with protection against MeS (OR = 0.56, 95% CI = 0.34-0.92, p = 0.020 D/I vs DD and OR = 0.54, 95% CI = 0.34-0.86, p = 0.009; D/I + I/I vs D/D). The I allele decreased the risk of MeS (OR = 0.62, 95% CI = 0.44-0.90, p = 0.011) in comparison with D allele.ConclusionIn conclusion, our result suggests that 45-bp I/D polymorphism is associated with the risk of MeS, which remains to be cleared.

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Section: Methodsmentioning

confidence: 99%

A 45-bp insertion/deletion polymorphism of UCP2 gene is associated with metabolic syndrome

Hashemi

Rezaei

Kaykhaei

et al. 2014

J Diabetes Metab Disord

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“…They prevent oxidation of serum lipids in metabolic disorders. Studies have demonstrated that there is an association between low levels of paraoxonase (PON1) and organ dysfunction, particularly in terms of cardiovascular pathologies seen in MetS patients (Eren et al 2014;Hashemi et al 2011).…”

Section: Introductionmentioning

confidence: 99%

Onset of decreased heart work is correlated with increased heart rate and shortened QT interval in high-carbohydrate fed overweight rats

Durak

Olğar

Tuncay

et al. 2017

Can. J. Physiol. Pharmacol.

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Mechanical activity of the heart is adversely affected with metabolic syndrome (MetS) characterized with increased body-mass and marked insulin-resistance.Herein, we examined effects of high-carbohydrate intake on cardiac functional abnormalities via evaluating in situ heart-work, heart-rate and electrocardiograms (ECG) in rats. MetS is induced in Wistar male rats by adding 32% sucrose for 22-24 weeks and confirmed with insulin-resistance, increased body-weight, blood glucose and insulin, systolic and diastolic blood pressures besides significant left ventricular integrity-lost and increased connective-tissue around myofibrils. Analysis of in situ ECG-recordings showed markedly shorten QT-interval and depressed QRP with increased heart-rate. We also observed augmented oxidative stress and decreased antioxidant defense characterized with decreases in serum total thiol-level and attenuated paraoxonase and arylesterase activities. Our data clearly indicate that increased heart-rate and shortened QT-interval concomitant with higher left ventricular developed pressure responses to β-adrenoreceptor stimulation as a result of less cAMP-release could be regarded as natural compensation mechanisms in overweight MetS rats. Since MetS leads further to persistent insulin-resistance and obesity, one should get into consideration these important facts associated with onset of the depressed heart-work, the increased heart-rate and shorten QT-interval in highcarbohydrate intake, which will possible lead to more deleterious effects on mammalian heart.

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“…Additionally, a recent study by Torun et al on MeS patients found higher TAS levels in the MeS group, which is parallel to the present study [ 26 ]. There are also some studies with no difference in TAS levels between MeS patients and the control group [ 27 ]. On the other hand, the finding of a positive correlation between TAS and EATT in the present study suggests that epicardial adipose tissue has an important role, not only in increased oxidative stress but also in the compensatory response to the increased oxidative stress.…”

Section: Discussionmentioning

confidence: 99%

The Association between the Epicardial Adipose Tissue Thickness and Oxidative Stress Parameters in Isolated Metabolic Syndrome Patients: A Multimarker Approach

Demir

Açıksarı

et al. 2014

International Journal of Endocrinology

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The risk for cardiovascular diseases and type 2 diabetes mellitus significantly increases in the patient population with metabolic syndrome (MeS). The present study aimed to investigate the association between the epicardial adipose tissue thickness (EATT) and the oxidative stress parameters in MeS patients. The study included 181 patients as a patient group of 92 consecutive patients with MeS and a control group of 89 consecutive patients with similar age and gender. EATT was evaluated by transthoracic echocardiography. Serum levels of total oxidant status (TOS), total antioxidative capacity (TAS), paraoxonase-1 (PON-1), and arylesterase activities were measured. EATT was higher in the MeS group compared to the control group (6.0 ± 2.0 mm and 4.0 ± 1.0 mm, resp.; P < 0.001). The level of TOS was higher in the MeS group compared to the control group (P < 0.001). Additionally, the TAS level was higher in the MeS group compared to the control group (P < 0.001). Furthermore, the serum levels of PON-1 and arylesterase were lower in the MeS group compared to the control group (P < 0.001). EAT may cause an increased risk of cardiovascular diseases by leading to increased oxidative stress in patients with MeS.

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Serum paraoxonase and arylesterase activities in metabolic syndrome in Zahedan, southeast Iran

Cited by 21 publications

References 26 publications

A 45-bp insertion/deletion polymorphism of UCP2 gene is associated with metabolic syndrome

A 45-bp insertion/deletion polymorphism of UCP2 gene is associated with metabolic syndrome

Onset of decreased heart work is correlated with increased heart rate and shortened QT interval in high-carbohydrate fed overweight rats

The Association between the Epicardial Adipose Tissue Thickness and Oxidative Stress Parameters in Isolated Metabolic Syndrome Patients: A Multimarker Approach

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