Serum polyamine alterations in surgical patients with colorectal carcinoma

Nishioka, Kenji; Romsdahl, Marvin M.; McMurtrey, Marion J.

doi:10.1002/jso.2930090605

Cited by 30 publications

(8 citation statements)

References 6 publications

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“…Our observations are in good agreement with those obtained by others [15][16][17] in respect to PUT and SPD. SPM, however, was found to be significantly elevated in the patients of Nishioka et al [15], in con trast to our findings.…”

Section: Discussionsupporting

confidence: 83%

“…SPM, however, was found to be significantly elevated in the patients of Nishioka et al [15], in con trast to our findings. The reason for the difference be tween the values in the literature and ours for SPM should be considered with regard to the different meth ods of sample preparation, i.e., in the extraction of total and free polyamines.…”

Section: Discussioncontrasting

confidence: 57%

“…Nishioka and Romsdahl [14,17] and Nishioka et al [15,16] have recently analyzed polyamines in the sera of patients with colorectal carcinoma. They de termined total polyamine content and confirmed their use in monitoring the clinical stage of patients with this disease [16,17],…”

Section: Introductionmentioning

confidence: 99%

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Rapid Detection of Polyamines in the Sera of Patients with Colorectal Carcinoma by Liquid Ion-Exchange Chromatography

Desser¹,

D²,

Krieger³

et al. 1980

Oncology

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The polyamines spermidine and spermine and the diamines putrescine and cadaverine have been determined in their free and unbound state in the sera of patients with colorectal carcinoma. The obtained values were compared with normal control levels. Elevated levels of putrescine and spermidine were found in untreated patients and declined to the control range after surgical and chemotherapeutic treatment. Spermine levels remained unchanged throughout the observation at normal control levels.

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Section: Discussionsupporting

confidence: 83%

Section: Discussioncontrasting

confidence: 57%

See 1 more Smart Citation

Rapid Detection of Polyamines in the Sera of Patients with Colorectal Carcinoma by Liquid Ion-Exchange Chromatography

Desser¹,

D²,

Krieger³

et al. 1980

Oncology

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“…These findings suggest the possibility that common factor(s), not specifically produced in cancer patients, can induce immunosuppressive conditions. Polyamines are one such factor, because blood polyamine levels, namely levels in blood cells including immune cells, are often increased in patients with various diseases [36,95-97]. …”

Section: Mechanism Of Metastasis and Involvement Of Polyamines (Fimentioning

confidence: 99%

The mechanisms by which polyamines accelerate tumor spread

Soda

2011

J Exp Clin Cancer Res

228

167

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Increased polyamine concentrations in the blood and urine of cancer patients reflect the enhanced levels of polyamine synthesis in cancer tissues arising from increased activity of enzymes responsible for polyamine synthesis. In addition to their de novo polyamine synthesis, cells can take up polyamines from extracellular sources, such as cancer tissues, food, and intestinal microbiota. Because polyamines are indispensable for cell growth, increased polyamine availability enhances cell growth. However, the malignant potential of cancer is determined by its capability to invade to surrounding tissues and metastasize to distant organs. The mechanisms by which increased polyamine levels enhance the malignant potential of cancer cells and decrease anti-tumor immunity are reviewed. Cancer cells with a greater capability to synthesize polyamines are associated with increased production of proteinases, such as serine proteinase, matrix metalloproteinases, cathepsins, and plasminogen activator, which can degrade surrounding tissues. Although cancer tissues produce vascular growth factors, their deregulated growth induces hypoxia, which in turn enhances polyamine uptake by cancer cells to further augment cell migration and suppress CD44 expression. Increased polyamine uptake by immune cells also results in reduced cytokine production needed for anti-tumor activities and decreases expression of adhesion molecules involved in anti-tumor immunity, such as CD11a and CD56. Immune cells in an environment with increased polyamine levels lose anti-tumor immune functions, such as lymphokine activated killer activities. Recent investigations revealed that increased polyamine availability enhances the capability of cancer cells to invade and metastasize to new tissues while diminishing immune cells' anti-tumor immune functions.

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“…Numerous studies have been published evaluating the clinical usefulness of these two polyamines in the diagnosis and treatment of many types of malignant disease (3)(4)(5)(6)(7)(8)(9)(10). One study reported putrescine levels to be a reliable biochemical marker of brain tumors (11).…”

Section: Introductionmentioning

confidence: 99%

Evaluation of polyamine levels in cerebrospinal fluid of children with brain tumors

1986

Self Cite

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Cerebrospinal fluid (CSF) polyamine levels were analyzed retrospectively in 21 pediatric patients with different types of intracranial malignant tumors to determine the benefit of following these markers during the clinical management of brain tumors. The tumors included 16 medulloblastomas and 1 each of germinoma, ependymoma, primitive neuroectodermal tumor, astrocytoma, and malignant teratoma. The clinical course of each patient was followed by neurologic examination, cranial computed tomography, CSF cell count, and cytology after cytocentrifugation. The correlation of CSF putrescine and spermidine levels with the clinical course of the brain tumors was analyzed. The following results were obtained: (1) A significant increase in CSF putrescine levels was observed in children with medulloblastoma when there was recurrent or metastatic disease in the sites close to the CSF pathway compared with the children whose disease status was stable after successful treatment (P less than 0.005). (2) The increase of CSF putrescine levels was the earliest predictor of recurrence or metastasis near the CSF pathway. (3) In tumors other than medulloblastoma, the levels of polyamines were not predictive of disease activity with the possible exception of germinoma. (4) Spermidine levels in the CSF were of limited clinical importance for patients with brain tumors. CSF putrescine levels may be the earliest and most sensitive quantitative marker of the progression of medulloblastoma, and their evaluation should be included in the diagnostic work-up and follow-up examination of children with medulloblastoma.

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Serum polyamine alterations in surgical patients with colorectal carcinoma

Cited by 30 publications

References 6 publications

Rapid Detection of Polyamines in the Sera of Patients with Colorectal Carcinoma by Liquid Ion-Exchange Chromatography

Rapid Detection of Polyamines in the Sera of Patients with Colorectal Carcinoma by Liquid Ion-Exchange Chromatography

The mechanisms by which polyamines accelerate tumor spread

Evaluation of polyamine levels in cerebrospinal fluid of children with brain tumors

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