Serum potassium concentrations following succinylcholine in patients undergoing beta-adrenoceptor blocking therapy

From, Robert P.; Mehta, M. P.; Pathak, Dhiren

doi:10.1016/0952-8180(89)90074-3

Cited by 3 publications

(1 citation statement)

References 15 publications

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“…Studies by Shin et al and From and colleagues however found no such causal relationship between the two drugs and advocated their use without any concerns raised [11,12].…”

Section: Discussionmentioning

confidence: 97%

Fatal hyperkalemia following succinylcholine administration in a child on oral propranolol

Ganigara

Ravishankar

Ramavakoda

et al. 2015

Drug Metabolism and Personalized Therapy

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Succinylcholine is one of the most commonly used drugs by anesthesiologists worldwide for rapid access to airway both in emergency and elective situations. Nonetheless, the very mention of succinylcholine generates the most energetic high decibel debate between its users and nonusers. Despite its potential to produce a short-acting, ultra-intense neuromuscular block rapidly in seconds, it is surrounded by a plethora of side effects and drug interactions. This case report is about one such drug interaction of this innocent yet malicious drug, which resulted in the death of a 14-year-old girl. Both β-adrenergic blockers and succinylcholine are known to cause hyperkalemia. Life-threatening hyperkalemia in susceptible individuals who have been administered succinylcholine has the most severe effect on the myocardium and can result in asystole with minimal chances of resuscitation. Both succinylcholine and a nonselective β-adrenergic blocker, propranolol, have the propensity to affect the transcellular redistribution of potassium which can result in hyperkalemia. We advocate cautious use of this drug combination till further studies confirm the drug interaction and find the potential triggering factors involved.

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“…Studies by Shin et al and From and colleagues however found no such causal relationship between the two drugs and advocated their use without any concerns raised [11,12].…”

Section: Discussionmentioning

confidence: 97%