Serum procollagen type III peptide as a marker of hepatic fibrogenesis in alcoholic hepatitis

M, Torres-Salinas; Parés, Albert; Caballería, Joan; Jiménez, Wladimiro; Heredia, D.; Bruguera, Miquel; Rodés, Joan

doi:10.1016/0016-5085(86)90391-4

Cited by 84 publications

(25 citation statements)

References 19 publications

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“…He measured the PIIINP concentrations in two groups of patients with alcoholic liver disease. Based on the results, he concluded that patients who developed severe liver fibrosis had significantly higher concentrations of PIIINP (1208 ± 154 cpm/mg) than patients who did not develop liver fibrosis (734 ± 138 cpm/mg) (Torres-Salinas et al 1986). His findings were confirmed by other scientists in various research centers (Bentsen et al 1978, Nouchi et al 1987, Trinchet et al 1992, Oberti et al 1997, Tran et al 2000, Stickel et al 2001).…”

Section: Discussionmentioning

confidence: 99%

Serum concentrations of PIIINP aminopeptide in dogs with liver fibrosis

Glińska-Suchocka¹,

Orłowska²,

Jankowski³

et al. 2016

Polish Journal of Veterinary Sciences

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The aim of the study was to evaluate the serum concentration of the type III procollagen aminopeptide in dogs, and to assess its utility in the diagnosis of liver fibrosis. The study was carried out on 20 dogs of different breeds and of both genders, between 7 and 15 years old. Based on the results of the histopathological examination and the evaluation of the degree of liver fibrosis, the dogs were divided into five groups. The mean serum PIIINP concentration in the group of dogs with stage 1 and 2 liver fibrosis (groups 2 and 3) was five-fold higher than in healthy dogs (group 1). In turn, the mean PIIINP concentration in the group of dogs with stage 3 (group 4) and stage 4 (group 5) fibrosis was 10-fold higher than that of the control group (group 1). Based on the results, we found that the serum PIIINP concentration correlated with the degree of liver fibrosis, assessed based on a histopathological examination. Therefore, PIIINP serum concentration tests may be a promising non-invasive diagnostic technique that could be used in veterinary hepatology to assess the degree of liver fibrosis.

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Section: Discussionmentioning

confidence: 99%

Serum concentrations of PIIINP aminopeptide in dogs with liver fibrosis

Glińska-Suchocka¹,

Orłowska²,

Jankowski³

et al. 2016

Polish Journal of Veterinary Sciences

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“…Human studies have shown a good correlation of hepatic prolyl hydroxylase, a key enzyme of collagen synthesis [6], and of hepatic procollagen ·1 (I) mRNA [7] with serum concentrations of PIIINP. In rats, we found that serum PIIINP levels were correlated well with hepatic procollagen ·1 (III) mRNA in the precirrhotic stage of carbon tetrachloride-induced liver fibrosis [8].…”

Section: Serum Markers As Tools To Assess Liver Fibrogenesis and Fibrmentioning

confidence: 99%

Serum Markers as Tools to Monitor Liver Fibrosis

Hayasaka

Saisho

1998

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“…We used the latter of these as the marker of fibrosis severity in the present study, since the logistics for FibroTest, Hepascore, and FibrometerA were not available. Nonetheless, procollagen III peptide is a valid marker of fibrosis severity and has been validated specifically in patients with alcoholic cirrhosis [18,19].…”

Section: Discussionmentioning

confidence: 99%

Carbohydrate Deficient Transferrin and Interleukin-6 as Predictors of Fibrosis in Alcohol Cirrhosis

et al. 2015

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The severity of alcoholic cirrhosis depends on the presence of liver inflammation and fibrogenesis. Previous studies have hypothesized that carbohydrate deficient transferrin can be used as marker of liver impairment in alcoholic liver disease patients. The present study was designed to assess whether carbohydrate deficient transferrin is associated with procollagen III peptide and predict fibrosis in alcohol cirrhosis patients. We enrolled 48 patients with alcoholic cirrhosis and 38 healthy controls. Serum carbohydrate deficient transferrin, procollagen III peptide and interleukin-6 levels were estimated in both groups. Serum carbohydrate deficient transferrin, procollagen III peptide and interleukin-6 were significantly increased in alcoholic cirrhosis patients compared to controls. Stepwise regression analysis showed that carbohydrate deficient transferrin (adjusted R 2 = 0.313, b = 0.362, p = 0.003) and interleukin-6 (adjusted R 2 = 0.194, b = 0.459, p = 0.001) were positively associated with procollagen III peptide when age, duration and amount of alcohol consumption were considered as covariates. We conclude that elevated carbohydrate deficient transferrin and interleukin-6 act as predictors of fibrosis in alcoholic cirrhosis.

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Serum procollagen type III peptide as a marker of hepatic fibrogenesis in alcoholic hepatitis

Cited by 84 publications

References 19 publications

Serum concentrations of PIIINP aminopeptide in dogs with liver fibrosis

Serum concentrations of PIIINP aminopeptide in dogs with liver fibrosis

Serum Markers as Tools to Monitor Liver Fibrosis

Carbohydrate Deficient Transferrin and Interleukin-6 as Predictors of Fibrosis in Alcohol Cirrhosis

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