Serum production against Crotalus durissus cascavella snake venom using a biotechnological approach as immunoadjuvant

Silva, Fiamma Gláucia Da; Soares, Karla Samara Rocha; França, Anne Caroline Ribeiro Bastos De; Torres-Rêgo, Manoela; Silva, Diana Pontes Da; Ferreira, Sarah de Sousa; Silva, Alaine Maria dos Santos; Júnior, Arnóbio Antônio da Silva; Pedrosa, Matheus De Freitas Fernandes

doi:10.1016/j.toxicon.2019.06.152

Cited by 1 publication

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“…Crotalus durissus cascavella venom proteins were incorporated into ChitNPs (stable and slightly smooth spherical NPs, <160 nm, SE 90%) as antivenom. They exhibited immunoadjuvant properties and reduced the adverse effects of venom, maximizing the efficiency of conventionally used antivenoms [ 54 ]. The authors also reported that these NPs are more effective than aluminum hydroxide, which is used as a conventional immunoadjuvant, suggesting that these nanosystems can be used in immunotherapy [ 149 ].…”

Section: Nanosystems and Nanocarriersmentioning

confidence: 99%

Nanobiotechnology with Therapeutically Relevant Macromolecules from Animal Venoms: Venoms, Toxins, and Antimicrobial Peptides

et al. 2022

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Some diseases of uncontrolled proliferation such as cancer, as well as infectious diseases, are the main cause of death in the world, and their causative agents have rapidly developed resistance to the various existing treatments, making them even more dangerous. Thereby, the discovery of new therapeutic agents is a challenge promoted by the World Health Organization (WHO). Biomacromolecules, isolated or synthesized from a natural template, have therapeutic properties which have not yet been fully studied, and represent an unexplored potential in the search for new drugs. These substances, starting from conglomerates of proteins and other substances such as animal venoms, or from minor substances such as bioactive peptides, help fight diseases or counteract harmful effects. The high effectiveness of these biomacromolecules makes them promising substances for obtaining new drugs; however, their low bioavailability or stability in biological systems is a challenge to be overcome in the coming years with the help of nanotechnology. The objective of this review article is to describe the relationship between the structure and function of biomacromolecules of animal origin that have applications already described using nanotechnology and targeted delivery.

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Section: Nanosystems and Nanocarriersmentioning

confidence: 99%