Serum progesterone testing to predict ectopic pregnancy in symptomatic first-trimester patients

Buckley, R. G.; King, Kerry J.; Disney, Jeffrey D.; Riffenburgh, Robert H.; Gorman, Jason J.; Klausen, Jack H.

doi:10.1067/mem.2000.108653

Cited by 34 publications

(10 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Many subsequent studies into the utility of progesterone as a biomarker for tubal ectopic pregnancy had similar results. Serum progesterone levels are significantly lower in tubal ectopic pregnancy but that they are not discriminative enough to be diagnostic in isolation (Mantzavinos et al 1991, Grosskinsky et al 1993, Kuscu et al 1993, Daily et al 1994, Ledger et al 1994, McCord et al 1996, O'Leary et al 1996, Mol et al 1998b, Buckley et al 2000, Condous et al 2004, Mueller et al 2004. However, the concept that progesterone can be a marker of serial hCG dynamics …”

Section: Progesteronementioning

confidence: 99%

Serum biomarkers of tubal ectopic pregnancy: current candidates and future possibilities

Cartwright¹,

Duncan²,

Critchley³

et al. 2009

Reproduction

View full text Add to dashboard Cite

Ectopic pregnancy remains a considerable cause of maternal morbidity and mortality worldwide. Currently, it is diagnosed using a combination of transvaginal ultrasound and serial serum b-human chorionic gonadotrophin levels. Diagnosis is often delayed and these tests are time-consuming and costly, both psychologically to the patient and financially to health services. The development of a biomarker that can differentiate a tubal ectopic from an intrauterine implantation is therefore important. In the pre-genomic era, a one-by-one scientific approach has revealed over 20 candidate biomarkers that could be used as a test to diagnose ectopic pregnancy although at present their clinical utility is very limited. These biomarkers cluster into themes: markers of abnormal embryo/trophoblast growth, markers of abnormal corpus luteum function, markers of a growing pregnancy in the Fallopian tube, markers of inflammation and peritoneal irritation, and uterine markers of normal implantation. It is likely that this thematic approach will facilitate the identification of newer biomarkers using microarray technology and inform the development of investigative paradigms using multiple markers at the time of presentation.

show abstract

Section: Progesteronementioning

confidence: 99%

Serum biomarkers of tubal ectopic pregnancy: current candidates and future possibilities

Cartwright¹,

Duncan²,

Critchley³

et al. 2009

Reproduction

View full text Add to dashboard Cite

show abstract

“…29 Both high (> 22 ng/mL) and low (≤ 5 ng/mL) cutoff points have since been studied for their ability to correctly identify nonviable pregnancy and ectopic pregnancy (Table 3). 30,31 Rapid progesterone analysis can identify 2 important subgroups of patients in the emergency department with symptomatic first-trimester bleeding or pain, or both: stable patients with progesterone levels above 22 ng/mL, who have a high (but not certain) likelihood of viable intrauterine pregnancy; and patients with levels of 5 ng/mL or less, who almost certainly have a nonviable pregnancy. Invasive diagnostic testing (e.g., D&C) could be postponed in the former patients but offered to the latter, as could treatment with methotrexate, without fear of interrupting a potentially viable intrauterine pregnancy.…”

Section: Use Of Progesterone Measurementmentioning

confidence: 99%

Diagnosis and treatment of ectopic pregnancy

Murray

Baakdah²,

Bardell³

et al. 2005

Canadian Medical Association Journal

237

173

View full text Add to dashboard Cite

“…Przyjęty schemat wartości progesteronu < 5 ng/ml dla ciąży ektopowej jest bardzo czuły. W praktyce jednak w 50% ciąż ektopowych, 20% poronień samoistnych i 70% żywych ciąż wewnątrzma-cicznych wartości progesteronu zawierają się w przedziale 5-20 ng/ml [17]. Trudną diagnostycznie grupą są pacjentki, u których ultrasonograficznie nie ma możli-wości uwidocznienia ciąży zarówno wewnątrzmacicz-nej, jak i ektopowej.…”

Section: Oznaczanie Progesteronuunclassified

Diagnosis and treatment of ectopic pregnancy

Sobstyl¹,

Tkaczuk-Włach²,

Bednarek³

et al. 2012

View full text Add to dashboard Cite

StreszczenieCiąże ektopowe stanowią średnio 1-2% wszystkich ciąż. Czynnikami ryzyka rozwoju ciąży ektopowej są: operacje w obrębie miednicy, PID, palenie papierosów, wiek matki powyżej 35 lat. Diagnoza niepękniętej ciąży ektopowej opiera się głównie na przezpochwowym badaniu ultrasonograficznym i seryjnych pomiarach stężenia gonadotropiny kosmówkowej β (β human chorionic gonadotrophin -β-HCG) w surowicy. Leczenie uzależnione jest od stanu ogólnego pacjentki, wielkości ciąży, stężenia β-HCG oraz planów prokreacyjnych pacjentki. W niektórych przypadkach ciąż ektopowych możliwe jest postępowanie wyczekujące.Słowa kluczowe: ciąża ektopowa, metotreksat, laparoskopia, β-HCG. SummaryEctopic pregnancy is reported in 1-2% of all pregnancies. Well-known risk factors for an ectopic pregnancy are: pelvic or abdominal surgery, PID, smoking of women in the reproductive age, age over 35 years and the increased use of assisted reproductive technology. The diagnosis in unruptured ectopic pregnancy has improved due to advances in TVS and measurement of serum β-HCG (β human chorionic gonadotrophin) concentration. Ectopic pregnancy treatment depends on the general status of women, the size of the gestation sac, serum β-HCG concentration and patient's preferences. Expectant management is possible in some cases of ectopic pregnancies.

show abstract

Serum progesterone testing to predict ectopic pregnancy in symptomatic first-trimester patients

Cited by 34 publications

References 17 publications

Serum biomarkers of tubal ectopic pregnancy: current candidates and future possibilities

Serum biomarkers of tubal ectopic pregnancy: current candidates and future possibilities

Diagnosis and treatment of ectopic pregnancy

Diagnosis and treatment of ectopic pregnancy

Contact Info

Product

Resources

About