Serum protein-based nanoparticles for cancer diagnosis and treatment

Iqbal, Haroon; Yang, Tao; Li, Ting; Zhang, Mi-Ya; Ke, Hengte; Ding, Dawei; Deng, Yibin; Chen, Huabing

doi:10.1016/j.jconrel.2020.10.030

Cited by 122 publications

(85 citation statements)

References 244 publications

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“…For example, Abraxane is used in the current cancer therapeutics. The paclitaxel-bound albumin nanocomplex has a diameter of around 130 nm and is one of the best-selling anticancer drugs in the market for breast cancer [ 59 ].…”

Section: Types Of Nanoparticlesmentioning

confidence: 99%

“…They are often used for small-molecular therapeutic drugs and imaging agents due to their minimal toxicity and immunogenicity, which also make them an excellent candidate for vaccine excipients. Although serum proteins are often used to conjugate therapeutic drugs, imaging probes, and targeting ligands, the random distribution of many amine and carboxyl groups in proteins causes irregularity of conjugation with target ligands [ 59 ]. The general strategies of developing protein-based nanoparticles may include desolvation, emulsification, biomineralization, and covalent/non-covalent interactions.…”

Section: Types Of Nanoparticlesmentioning

confidence: 99%

“…They make a great candidate for drug and gene delivery. Naturally derived proteins, such as albumin, have been used in the market as anticancer treatments [ 59 , 60 ].…”

Section: Types Of Nanoparticlesmentioning

confidence: 99%

“…Developments in cancer nanomedicine in the past decade have focused on enhancing efficacy while reducing adverse side effects. Researchers often focus on the ability of the delivery vehicles or the drugs themselves to target tumors and improve the biodistribution in the body [ 59 ]. The rest of this review discusses the different biomaterials, especially nanoparticle-based therapeutic strategies, ranging from the use of protein—based as naturally derived nanocarriers for anticancer drugs—to exploiting the function of T cells by developing antigen/adjuvant vaccines, or genetically engineered T cells to improve the immunity of the hosts, and gene modification—especially using CRISPR/Cas9 system.…”

Section: Proteins and Peptides Delivery As Anticancer Therapeuticsmentioning

confidence: 99%

“…Different vaccine particle sizes may go through different uptake routes as described in Khong et al in the paper published in 2016 [ 115 ]. While the complex fabrication process to develop natural proteins as nanocarriers or drugs is still impeding the use of these nanocarriers, it is worth noting that they may greatly improve the response rate and the potential advantages they possess may be the motivation behind many investigations of these nanocarriers [ 59 ].…”

Section: Proteins and Peptides Delivery As Anticancer Therapeuticsmentioning

confidence: 99%

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Nanomaterials for Protein Delivery in Anticancer Applications

2021

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Nanotechnology platforms, such as nanoparticles, liposomes, dendrimers, and micelles have been studied extensively for various drug deliveries, to treat or prevent diseases by modulating physiological or pathological processes. The delivery drug molecules range from traditional small molecules to recently developed biologics, such as proteins, peptides, and nucleic acids. Among them, proteins have shown a series of advantages and potential in various therapeutic applications, such as introducing therapeutic proteins due to genetic defects, or used as nanocarriers for anticancer agents to decelerate tumor growth or control metastasis. This review discusses the existing nanoparticle delivery systems, introducing design strategies, advantages of using each system, and possible limitations. Moreover, we will examine the intracellular delivery of different protein therapeutics, such as antibodies, antigens, and gene editing proteins into the host cells to achieve anticancer effects and cancer vaccines. Finally, we explore the current applications of protein delivery in anticancer treatments.

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Section: Types Of Nanoparticlesmentioning

confidence: 99%

Section: Types Of Nanoparticlesmentioning

confidence: 99%

“…They make a great candidate for drug and gene delivery. Naturally derived proteins, such as albumin, have been used in the market as anticancer treatments [ 59 , 60 ].…”

Section: Types Of Nanoparticlesmentioning

confidence: 99%

Section: Proteins and Peptides Delivery As Anticancer Therapeuticsmentioning

confidence: 99%

Section: Proteins and Peptides Delivery As Anticancer Therapeuticsmentioning

confidence: 99%

See 3 more Smart Citations

Nanomaterials for Protein Delivery in Anticancer Applications

2021

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The Construction of Polyphotocage Platform for Anticancer Photochemotherapy

Wang

Zhang

et al. 2023

Adv Funct Materials

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Photocages enable the precise activation of molecular function with light in many research fields, such as anticancer treatment, where remote spatiotemporal control over the release of an active drug is needed. However, the poor physiological stability and tumor accumulation of conventional small molecular photocages are significant obstacles to developing efficient therapy in vivo. In this study, a new concept of "polyphotocage" is proposed through photocage-polymer hybrid macromolecular engineering. Photoresponsive Ru complex photocage is designed and fused with PEGylated poly carbonates, resulting in the polyphotocage. Various anticancer drugs can be readily conjugated to the polyphotocage via coordination linkage, which can be cut off to release drugs by red light. The polyphotocages can self-assemble into nanoparticles, which enhances the stability of the Ru photocage and demonstrates the efficient accumulation in different-sized tumorswith a high signal-to-background ratio. Furthermore, rapid cellular internalization and mitochondrial anchoring capability allowed the polyphotocages to deliver drugs into the mitochondria, which induces mitochondrial dysfunction and cell death. These properties ensure the effective delivery of anticancer drugs to solid tumors and multiple tiny tumors, ultimately inhibiting tumor proliferation. This strategy of polyphotocages provides a new platform for the future design of drug-delivery systems for cancer photochemotherapy.

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Innovative Design Strategies Advance Biomedical Applications of Phthalocyanines

Cai

Wang

et al. 2023

Adv Healthcare Materials

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Owing to their long absorption wavelengths, high molar absorptivity, and tunable photosensitivity, phthalocyanines have been widely used in photodynamic therapy (PDT). However, phthalocyanines still face the drawbacks of poor targeting, “always‐on” photosensitizing properties, and unsatisfactory therapeutic efficiency, which limit their wide applications in biomedical fields. Thus, new design strategies such as modification of targeting molecules, formation of nanoparticles, and activating photosensitizers are developed to improve the above defects. Notably, recent studies have shown that novel phthalocyanines are not only used in fluorescence imaging and PDT, but also in photoacoustic imaging, photothermal imaging, sonodynamic therapy, and photothermal therapy. This review focuses on recent design strategies, applications in biomedicine, and clinical development of phthalocyanines, providing ideas and references for the design and application of phthalocyanine, so as to promote their future transformation into clinical applications.

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Serum protein-based nanoparticles for cancer diagnosis and treatment

Cited by 122 publications

References 244 publications

Nanomaterials for Protein Delivery in Anticancer Applications

Nanomaterials for Protein Delivery in Anticancer Applications

The Construction of Polyphotocage Platform for Anticancer Photochemotherapy

Innovative Design Strategies Advance Biomedical Applications of Phthalocyanines

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