Serum proteomic analysis reveals possible mechanism underlying physiological hemostasis of swim bladder

Xiao, Lanfei; Liang, Yongjun; Ye, Xiaokang; Zhang, Haoran; Lv, Jiehuan; Dong, Hui; Lin, Fan; Wen, Xiaobo

doi:10.1016/j.jprot.2022.104668

Cited by 5 publications

(2 citation statements)

References 37 publications

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“…Various physiological functions of pea protein-derived bioactive peptides have been reported, which indicates great potential for pea protein-derived bioactive peptides in the management of chronic diseases [ 13 , 14 ]. Although the anti-diabetic activity of pea protein-derived bioactive peptides have been documented [ 15 ], the underlying mechanisms remain to be elucidated.…”

Section: Introductionmentioning

confidence: 99%

Pea Protein-Derived Peptides Inhibit Hepatic Glucose Production via the Gluconeogenic Signaling in the AML-12 Cells

Liao¹,

Cao²,

Xia³

et al. 2022

IJERPH

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Pea protein is considered to be a high quality dietary protein source, but also it is an ideal raw material for the production of bioactive peptides. Although the hypoglycemic effect of pea protein hydrolysate (PPH) has been previously reported, the underlying mechanisms, in particular its effect on the hepatic gluconeogenesis, remain to be elucidated. In the present study, we found that PPH suppressed glucose production in mouse liver cell-line AML-12 cells. Although both of the gluconeogenic and insulin signaling pathways in the AML-12 cells could be regulated by PPH, the suppression of glucose production was dependent on the inhibition of the cAMP response element-binding protein (CREB)-mediated signaling in the gluconeogenic pathway, but not the activation of insulin signaling. Findings from the present study have unveiled a novel role of PPH underlying its anti-diabetic activity, which could be helpful to accelerate the development of functional foods and nutraceuticals using PPH as a starting material.

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Section: Introductionmentioning

confidence: 99%

Pea Protein-Derived Peptides Inhibit Hepatic Glucose Production via the Gluconeogenic Signaling in the AML-12 Cells

Liao¹,

Cao²,

Xia³

et al. 2022

IJERPH

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show abstract

“…8,9 Isinglass, relatively famous and obtained from Bahaba taipingensis, Nibea coibor (white gelatin), Protonibea diacanthus etc., 10,11 is a dried product of the swim bladder (a buoyancyregulating organ in fish) and it is one of the most precious seafood and a traditional Chinese medicine for improving blood circulation, arrest bleeding, and improve joint condition. 12,13 It has been reported that in vitro hydrolysated collagen peptides from the swim bladder show antioxidant activity. 14,15 However, natural antioxidant peptides after digestion and absorption in vivo remain unknown.…”

Section: Introductionmentioning

confidence: 99%

Identification of antioxidant peptides after digestion and absorption of isinglass by serum peptidomics and cellular antioxidant activity analysis

Xiao

Liang

et al. 2023

Food Funct.

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Effects of fish meal replacement with composite proteins source on growth performance, antioxidant capacity and swim bladder quality of chu’s croaker (Nibea coibor)

Serum proteomic analysis reveals possible mechanism underlying physiological hemostasis of swim bladder

Cited by 5 publications

References 37 publications

Pea Protein-Derived Peptides Inhibit Hepatic Glucose Production via the Gluconeogenic Signaling in the AML-12 Cells

Pea Protein-Derived Peptides Inhibit Hepatic Glucose Production via the Gluconeogenic Signaling in the AML-12 Cells

Identification of antioxidant peptides after digestion and absorption of isinglass by serum peptidomics and cellular antioxidant activity analysis

Effects of fish meal replacement with composite proteins source on growth performance, antioxidant capacity and swim bladder quality of chu’s croaker (Nibea coibor)

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