Serum retinol-binding protein 4 levels in nonobese women with polycystic ovary syndrome

Chan, Te-Fu; Tsai, Yung-Chieh; Chiu, Pu-Rong; Lee, Chien-Hung; Tsai, Eing‐Mei

doi:10.1016/j.fertnstert.2008.10.039

Cited by 15 publications

(19 citation statements)

References 36 publications

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“…Because they observed a small independent impact of RBP4 on IR, RBP4 was not found to be suitable for metabolic screening in women with PCOS. Chan et al (34) reported a significant correlation between TG and RBP4 and suggested that RBP4 levels might not be a useful marker of IR.…”

Section: Discussionmentioning

confidence: 99%

Serum retinol-binding protein 4, leptin, and plasma asymmetric dimethylarginine levels in obese and nonobese young women with polycystic ovary syndrome

Yıldızhan

İlhan

Yıldızhan

et al. 2011

Fertility and Sterility

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Section: Discussionmentioning

confidence: 99%

Serum retinol-binding protein 4, leptin, and plasma asymmetric dimethylarginine levels in obese and nonobese young women with polycystic ovary syndrome

Yıldızhan

İlhan

Yıldızhan

et al. 2011

Fertility and Sterility

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“…So me of the ot her pre vi o us in ves ti ga ti ons al so re ve a led similar results. 16,26 In cer ta in stu di es that reported an in cre a se in le vels of RBP4 in sub jects with PCOS a cor re la tion has be en shown bet we en RBP4 and in su lin resis tan ce . 16,19 On the con trary, so me ot her investigations did not find any cor re la ti on bet ween increased RBP4 le vel and in su lin re sis tan ce.…”

Section: Discussionmentioning

confidence: 99%

Elevated Serum Retinol Binding Protein 4 Level in Non-Obese Women with Polycystic Ovary Syndrome

Akbay¹,

Gen²,

Muşlu³

et al. 2011

Turkiye Klinikleri J Med Sci

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A AB BS S T TR RA AC CT T O Ob b j je ec c t ti i v ve e: : It has be en shown that in su lin re sis tan ce in wo men with polyc ystic ovary syndro me (PCOS) is in de pen dent of obe sity and body com po si ti on. Re ti nol bin ding pro te in 4 (RBP 4) is an adi po ki ne which plays a ro le in in su lin re sis tan ce in as so ci a ti on with glu co se trans por ter 4 (GLUT 4). In this study, we ai med to eva lu a te the re la ti ons hip of RBP4 with hor mo nal, me ta bo lic pa ra me ters and in ter le u kin-6 (IL-6) as a mar ker of subc li ni cal inf lam ma ti on in non-obe se pa ti ents with PCOS. M Ma a t te e r ri i a al l a an nd d M Me et t h ho od ds s: : The study gro ups we re com po sed of 21 non-obe se wo men with PCOS and 15 he althy, nor mally mens tru a ting wo men. Se rum con cen tra ti ons of RBP4 and IL-6 were de ter mi ned along with me ta bo lic and hor mo nal pa ra me ters. R Re e s su ul lt ts s: : HO MA-IR va lu es and serum RBP4 le vels in PCOS gro up we re sig ni fi cantly in cre a sed com pa red to the con trol gro up. RBP4 le vels we re sho wing po si ti ve cor re la ti on with IL-6 and 17-HP in the PCOS gro up. Ho we ver, there was no cor re la ti on bet we en se rum RBP4 le vels and me ta bo lic and hor mo nal pa ra me ters. Pa tients with se rum RBP4 con cen tra ti ons hig her than the me di an le vel we re mo re in su lin re sis tant than pa ti ents with se rum RBP con cen tra ti ons lo wer than the me di an le vel, and they had hig her insu lin and 17-hydroxy pro ges te ro ne va lu es. C Co on nc c l lu u s si i o on n: : Our da ta in di ca te that se rum RBP4 le vels incre a se in le an in su lin re sis tant wo men with PCOS. Event ho ugh this in cre a se was cor re la ted with in su lin re sis tan ce, pa ti ents with sig ni fi cantly high le vels of RBP4 had mo re in su lin re sis tan ce. Eleva ted se rum RBP4 le vels in non-obe se pa ti ents with PCOS was re la ted to IL-6, whe re as the re was no re la ti ons hip with ot her me ta bo lic pa ra me ters and tes tos te ro ne le vels. K Ke ey y W Wo or rd ds s: : RBP4 pro te in, hu man; polyc ystic ovary syndro me; inter le u kin-6; insu lin re sis tan ce Ö ÖZ ZE ET T A Am ma aç ç: : Po li kis tik over sen drom lu (PKOS) ka dın lar da in sü lin di ren ci nin obe zi te ve vü cut kom po zis yo nun dan ba ğım sız ol du ğu gös te ril miş tir. Re ti nol bağ la yı cı pro te in 4 (RBP 4) glu koz ta -şı yı cı sı 4 (GLUT 4) ile iliş ki li ola rak in sü lin di ren cin de rol oy na yan bir adi po kin dir. Bu ça lış ma da, RBP4'ün obez ol ma yan PKOS' lu has ta lar da hor mo nal, me ta bo lik pa ra met re ler ve subk li nik inf lamas yo nun bir gös ter ge si olan in ter lö kin-6 (IL-6) ile olan iliş ki si nin de ğer len di ril me si amaç lan dı. G Ge e --r re eç ç v ve e Y Yö ön n t te em m l le er r: : Nor mal ki lo lu 21 PCOS' lu has ta ve nor mal mens tru as yo nu olan 15 sağ lık lı ka dın kon trol gru bu ola rak ça lış ma ya alın dı. RBP4 ve IL-6 dü zey le ri me ta bo lik ve hor mo nal pa ra met reler le bir lik te de ğer len di ril di. B B...

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“…Podaci iz literature pokazuju povećane vrednosti RBP4 u stanjima smanjene tolerancije glukoze [13], kod gojaznih osoba [14], kod dijabetičara [15], kod osoba sa sindromom policističnih ovarijuma [16], tj. u svim stanjima koja su usko povezana sa IR.…”

Section: Masno Tkivo Kao Izvor Sekrecije Retinolvezujućeg Proteinaunclassified

Retinol-binding protein 4 and hyperinsulinemia: The link between obesity and cardiovascular disease

Klisić¹,

Jovanović²,

Kavarić³

et al. 2017

Tim Med Glas

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(1) DOM ZDRAVLJA PODGORICA, CRNA GORA, (2) KLINIČKI CENTAR CRNE GORE Sažetak:Kardiovaskularne bolesti (KVB) su vodeći uzrok smrtnosti u svetu, a gojaznost predstavlja jedan od glavnih faktora rizika za ove bolesti. Poremećena sekrecija adipokina [npr., visoke koncentracije retinol-vezujućeg proteina 4 (RBP4), rezistina, leptina, a niske koncentracije adiponektina], inflamacija niskog stepena, kao i povećana produkcija reaktivnih vrsta kiseonika, dovode do poremećaja niza signalnih puteva, insulinske rezistencije (IR), kao i KVB. RBP4 je skoro otkriven adipokin za koji se pretpostavlja da je usko povezan sa IR. Uprkos oprečnim rezultatima brojnih studija, pretpostavlja se da je ovaj protein značajan kardiometabolički faktor rizika, čije visoke koncentracije dovode do nastanka metaboličkog sindroma, tipa 2 dijabetesa i KVB. Bolje poznavanje patofizioloških mehanizama koji dovode do povećanja RBP4 i insulina u krvi mogu dovesti do pronalaska adekvatne terapeutske strategije u cilju smanjenja kardiovaskularnog rizika, pa samim tim i bolesti srca i krvnih sudova kod osoba sa viškom telesne mase. Ključne reči: kardiovaskularne bolesti, retinol-vezujući protein 4, insulinska rezistencija, gojaznost. Summary:Cardiovascular disease (CVD) is the leading cause of death in the world and obesity is one of the main risk factors. Irregular secretion of adipokines [e.g. high retinol binding protein 4 (RBP4), resistin, leptin, respectively, but low adiponectin], low-grade inflammation, as well as an increased production of reactive oxygen species, may lead to impaired insulin signalling, insulin resistance (IR) and CVD. RBP4 is a recently discovered adipokine which is supposed to be closely related to IR. Despite contradictory results obtained from a large number of studies, it is assumed to be a significant cardiometabolic risk factor, leading to metabolic syndrome, type 2 diabetes and CVD development. Better understanding of the patophysiological mechanisms of increased RBP4 and hyperinsulinemia in circulation may lead to a discovery of new target therapy in prevention of CVD, especially in those people who are overweight/obese.

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Serum retinol-binding protein 4 levels in nonobese women with polycystic ovary syndrome

Cited by 15 publications

References 36 publications

Serum retinol-binding protein 4, leptin, and plasma asymmetric dimethylarginine levels in obese and nonobese young women with polycystic ovary syndrome

Serum retinol-binding protein 4, leptin, and plasma asymmetric dimethylarginine levels in obese and nonobese young women with polycystic ovary syndrome

Elevated Serum Retinol Binding Protein 4 Level in Non-Obese Women with Polycystic Ovary Syndrome

Retinol-binding protein 4 and hyperinsulinemia: The link between obesity and cardiovascular disease

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