Serum selenium level and gestational diabetes mellitus: a systematic review and meta-analysis

Kong, Fanhua; Ma, Liang; Chen, Shuping; Li, Ge; Zhou, Jiaheng

doi:10.1186/s12937-016-0211-8

Cited by 42 publications

(37 citation statements)

References 43 publications

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“…In women with GDM (in retrospective studies), the relationships between higher levels of plasma Cu and GDM were found [17,18]. Retrospective studies indicate that there are discrepancies in the relationships between Fe, Se, and Zn, and GDM risk [38][39][40][41].…”

Section: Discussionmentioning

confidence: 99%

First Trimester Microelements and Their Relationships with Pregnancy Outcomes and Complications

Lewandowska

Więckowska

Sajdak³

et al. 2020

Nutrients

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Microelements involved in the oxidative balance have a significant impact on human health, but their role in pregnancy are poorly studied. We examined the relationships between first trimester levels of selenium (Se), iron (Fe), zinc (Zn), and copper (Cu), as well as maternal characteristics and pregnancy results. The data came from a Polish prospective cohort of women in a single pregnancy without chronic diseases. A group of 563 women who had a complete set of data, including serum microelements in the 10–14th week was examined, and the following were found: 47 deliveries <37th week; 48 cases of birth weight <10th and 64 newborns >90th percentile; 13 intrauterine growth restriction (IUGR) cases; 105 gestational hypertension (GH) and 15 preeclampsia (PE) cases; and 110 gestational diabetes mellitus (GDM) cases. The microelements were quantified using mass spectrometry. The average concentrations (and ranges) of the elements were as follows: Se: 60.75 µg/L (40.91–125.54); Zn: 618.50 µg/L (394.04–3238.90); Cu: 1735.91 µg/L (883.61–3956.76); and Fe: 1018.33 µg/L (217.55–2806.24). In the multivariate logistic regression, we found that an increase in Se of 1 µg/L reduces the risk of GH by 6% (AOR = 0.94; p = 0.004), the risk of IUGR by 11% (AOR = 0.89; p = 0.013), and the risk of birth <34th week by 7% (but close to the significance) (AOR = 0.93; p = 0.061). An increase in Fe of 100 µg/L reduces the risk of PE by 27% (AOR = 0.73; p = 0.009). In the multivariable linear regression, we found negative strong associations between prepregnancy BMI, Se (β = −0.130; p = 0.002), and Fe (β = −0.164; p < 0.0001), but positive associations with Cu (β = 0.320; p < 0.000001). The relationships between Se and maternal age (β = 0.167; p < 0.0001), Se and smoking (β = −0.106; p = 0.011) and Cu, and gestational age from the 10–14th week (β = 0.142; p < 0.001) were also found. Secondary education was associated with Zn (β = 0.132; p = 0.004) and higher education was associated with Cu (β = −0.102; p = 0.023). A higher financial status was associated with Fe (β = 0.195; p = 0.005). Other relationships were statistically insignificant. Further research is needed to clarify relationships between first trimester microelements and pregnancy complications. In addition, attention should be paid to lifestyle-related and socioeconomic factors that affect microelement levels.

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Section: Discussionmentioning

confidence: 99%

First Trimester Microelements and Their Relationships with Pregnancy Outcomes and Complications

Lewandowska

Więckowska

Sajdak³

et al. 2020

Nutrients

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“…Maternal Se deficiency is associated with decreased neonatal Se status, which increases the risk for multiple neonatal morbidities [ 11 , 18 , 52 , 53 ]. This suggests an important role for Se during embryonic and neonatal development.…”

Section: Discussionmentioning

confidence: 99%

“…We speculate this may have important clinical implications. Maternal Se deficiency can occur with maternal malnutrition or secondary to antenatal states such as pre-eclampsia and gestational diabetes [ 39 , 41 , 52 , 71 ]. Furthermore, the majority of fetal Se acquisition occurs during the third trimester, thus infants born premature are at high risk for Se deficiency [ 41 ].…”

Section: Discussionmentioning

confidence: 99%

Neonatal Selenoenzyme Expression Is Variably Susceptible to Duration of Maternal Selenium Deficiency

et al. 2021

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Maternal selenium (Se) deficiency is associated with decreased neonatal Se levels, which increases the risk for neonatal morbidities. There is a hierarchy to selenoprotein expression after Se deficiency in adult rodents, depending on the particular protein and organ evaluated. However, it is unknown how limited Se supply during pregnancy impacts neonatal selenoprotein expression. We used an Se-deficient diet to induce perinatal Se deficiency (SeD), initiated 2–4 weeks before onset of breeding and continuing through gestation. Neonatal plasma, liver, heart, kidney, and lung were collected on the day of birth and assessed for selenoproteins, factors required for Se processing, and non-Se containing antioxidant enzymes (AOE). Maternal SeD reduced neonatal circulating and hepatic glutathione peroxidase (GPx) activity, as well as hepatic expression of Gpx1 and selenophosphate synthetase 2 (Sps2). In contrast, the impact of maternal SeD on hepatic thioredoxin reductase 1, hepatic non-Se containing AOEs, as well as cardiac, renal, and pulmonary GPx activity, varied based on duration of maternal exposure to SeD diet. We conclude that the neonatal liver and circulation demonstrate earlier depletion in selenoenzyme activity after maternal SeD. Our data indicate that prolonged maternal SeD may escalate risk to the neonate by progressively diminishing Se-containing AOE across multiple organs.

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“… 29 Similarly low levels of Se have also been reported in women with gestational diabetes mellitus. 30 Se is an anti-oxidant and provides protection against oxidative stress 31 that has been implicated in the etiology, pathogenesis and complications of T2DM. 32 Deficiency of Se may therefore be a predisposition for development of diabetes.…”

Section: Discussionmentioning

confidence: 99%

Trace elements in type 2 diabetes mellitus and their association with glycemic control

Hasanato¹

2020

Afr H. Sci.

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Background: Alterations in serum levels of trace elements reported in type 2 diabetes mellitus (T2DM) have been linked with induction of T2DM and associated complications. Objectives: To assess serum levels of copper (Cu), zinc (Zn) and selenium (Se) in T2DM patients with adequate and poor gly- cemic control. Patients and methods: This study was performed at King Khalid University Hospital, Riyadh. A total of 100 consenting T2DM patients comprising of 50 patients with glycated hemoglobin (HbA1c) less than 6.5% and 50 patients with HbA1c more than 6.5% along with a group of 50 normal healthy individuals were included in the study. Serum levels of Cu, Zn and Se were measured by inductively coupled plasma-mass spectrometry (ICP-MS) instrument. Results: Among T2DM patients with HbA1c <6.5%, mean serum Cu levels (13.4+4.3μmol/L) were not different from the controls (14.5+1.92μmol/L) whereas Zn (9.9+2.7μmol/Lvs15+3.2μmol/L;p<0.0001) and Se levels (1+0.2μmol/ Lvs1.62+0.2μmol/L; p<0.0004) were lower than the controls. Among T2DM patients with HbA1c >6.5% mean serum Cu (18.1+4.1μmol/Lvs14.5+1.9μmol/L; p<0.0001), Zn (15+3.2μmol/Lvs13.5+1.9μmol/L; p<0.009) and Se (1.62+0.2μmol/ Lvs1.17+0.16μmol/L;p<0.0001) were significantly higher than the controls. HbA1c% negatively correlated with HbA1c >6.5% (r = -0.302; p<0.03). Conclusion: Cu, Zn and Se homeostasis was altered in T2DM patients and varied with glycemic control. Keywords: Copper; Zinc; Selenium; trace elements; diabetes mellitus.

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Serum selenium level and gestational diabetes mellitus: a systematic review and meta-analysis

Cited by 42 publications

References 43 publications

First Trimester Microelements and Their Relationships with Pregnancy Outcomes and Complications

First Trimester Microelements and Their Relationships with Pregnancy Outcomes and Complications

Neonatal Selenoenzyme Expression Is Variably Susceptible to Duration of Maternal Selenium Deficiency

Trace elements in type 2 diabetes mellitus and their association with glycemic control

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