Serum selenium level in Iranian patients with alopecia areata

Feizy, Vida; Mortazavi, Hossein; Barikbin, Behrooz; Yousefi, Maryam; Ranjbar, Alireza; Farshchian, Mehdi

doi:10.1111/j.1468-3083.2008.02612.x

Cited by 6 publications

(4 citation statements)

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“…Magnesium acts as a cofactor for over 300 enzyme systems, and plays an important role in nucleotide synthesis, a frequent process in the rapidly dividing hair follicle [64]. A small number of studies have investigated the serum levels of these elements in AA (Table 3) [54–58, 65] and few have identified an association between low levels and AA. In one study [56] of 27 AA patients from Iran, serum and hair copper levels were lower in AA patients compared to controls.…”

Section: Micronutrientsmentioning

confidence: 99%

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The Role of Micronutrients in Alopecia Areata: A Review

et al. 2017

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Alopecia areata (AA) is a common, non-scaring form of hair loss caused by immune-mediated attack of the hair follicle. As with other immune-mediated diseases, a complex interplay between environment and genetics is thought to lead to the development of AA. Deficiency of micronutrients such as vitamins and minerals may represent a modifiable risk factor associated with development of AA. Given their role in normal hair follicle development and in immune cell function, a growing number of investigations have sought to determine whether serum levels of these nutrients might differ in AA patients, and whether supplementation of these nutrients might represent a therapeutic option for AA. While current treatment often relies on invasive steroid injections or immunomodulating agents with potentially harmful side-effects, therapy by micronutrient supplementation, whether as a primary modality or as adjunctive treatment, could offer a promising low-risk alternative. However, our review highlights a need for further research in this area, given that the current body of literature largely consists of small case-control studies and case-reports which preclude any definite conclusions for a role of micronutrients in AA. In this comprehensive review of the current literature we found that serum vitamin D, zinc, and folate levels tend to be lower in patients with AA as compared to controls. Evidence is conflicting or insufficient to suggest differences in levels of iron, vitamin B12, copper, magnesium, or selenium. A small number of studies suggest that vitamin A levels may modify the disease. Though understanding of the role for micronutrients in AA is growing, definitive clinical recommendations such as routine serum level testing or therapeutic supplementation, call for additional studies in larger populations and with a prospective design.

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Section: Micronutrientsmentioning

confidence: 99%

“…Regarding selenium, two studies have yielded conflicting results. In an Iranian study [65], 29 patients had lower selenium levels compared to controls, while a Finish study found no differences between AA cases and controls [58]. …”

Section: Micronutrientsmentioning

confidence: 99%

The Role of Micronutrients in Alopecia Areata: A Review

et al. 2017

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“…The primary indicator of iron status relied upon in hair loss studies is serum ferritin. Serum levels of this iron-binding protein reflect a patient's total iron storage [8].Therefore, this study aimed to investigate the role of zinc and ferritin in patients with alopecia areata…”

Section: Introductionmentioning

confidence: 99%

Investigate the role of Zinc and Ferritin in Iraqi patients with alopecia areata

Al-Ibraheemi¹,

Shaboot²,

Zyara³

2023

World J. Bio. Pharm. Health Sci.

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Alopecia areata (AA) is an auto-immune disease in which there is an inflammation around the anagen phase of hair follicles. Many nutritional elements were found to modulate this immune response. Zinc and ferritin have many vital roles inside the body and are considered among the most important nutritional factors in immune modulation and division of hair follicle matrix cells. This study aimed to investigate the role of zinc and ferritin in patients with alopecia areata. A case control study including a total of 40 patients with AA who were attending the outpatient clinic at Al-Kindy Teaching Hospital, Baghdad during the period from 2nd June 2019 to 31st March 2020. Other 65 age- and gender- matched apparently healthy subjects. Demographic of the patients and controls and clinical data of the patients were recorded through direct interview. Blood samples were collected from all participants, and serum level of zinc and ferritin were measured using enzyme linked immunosorbent assay(Elisa). Results revealed that in three-fourth of the patients, only scalp was involved in the lesion, while mixed lesion was reported in the 25% of the patients. Single and multiple lesions were reported in 42.5% and 57.5% of the patients respectively. Median serum level of ferritin in patients was 23.0 μg/L (range=3-98 μg/L) which was lower than that of controls (median = 27.0 μg/L, range= 10-166 μg/L) with a significant difference. Likewise, median serum level of zinc was 59.5 μg/dl (range= 15-175 μg/dl) in patients compared with 71.5 μg/dl (range= 21-201 μg/dl) in controls with a significant difference. Zinc level showed a significant positive correlation with age (r= 0.334, p= 0.041) and negative correlation with lesion size (r= -0.327, p= 0.045). In conclusion, multiple lesions in the scalp are the most common presentation of patients with AA. Low levels of ferritin and/or zinc could be involved in the pathogenesis of AA and increase the risk of disease severity.

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“…An Iranian study has compared patients with several degrees of alopecia areata to a control group and observed significantly lower serum selenium levels in the first group though there was no statistical difference among cases. [ 5 ] In our own records, 40 patients with alopecia areata were evaluated with serum selenium dosage, and there was no statistically significant difference between them and a control group.…”

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confidence: 99%