Serum testosterone level correlates with left ventricular hypertrophy in older women

Szadkowska, Iwona; Guligowska, Agnieszka; Jegier, Anna; Pawlikowski, Marek; Pisarek, Hanna; Winczyk, Katarzyna; Kostka, Tomasz

doi:10.3389/fendo.2022.1079043

Cited by 4 publications

(3 citation statements)

References 58 publications

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“…Whether the prevalence of LVH is higher in women than in men is debatable [32–35]. However, it is widely acknowledged that the prevalence of LVH is higher in postmenopausal women than in men [32], which may be related to higher serum testosterone levels [36, 37]. Among patients with LVH in this trial, the proportion of women was 37/72, equivalent to that of men.…”

Section: Discussionmentioning

confidence: 97%

Roxadustat reduces left ventricular mass index compared to rHuEPO in haemodialysis patients in a randomized controlled trial

Tan,

Wang,

Sun

et al. 2024

J Intern Med

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BackgroundLeft ventricular hypertrophy (LVH) is highly prevalent in haemodialysis (HD) patients and is associated with an increased risk of death. Roxadustat and recombinant human erythropoietin (rHuEPO, abbreviated as EPO) are the main treatment strategies for renal anaemia in HD patients, but it has not been clear whether there is a difference in their effect on LVH.MethodsIn this multi‐centre, prospective, randomized trial of 12‐month duration, study participants were randomized in a 1:1 ratio to the roxadustat group or the EPO group. The doses of both treatment regimens were adjusted so that the patients had a haemoglobin level of 10.0–12.0 g per dL. The primary study endpoint was the change from baseline to 12 months in the left ventricular mass index (LVMI, g/m2) measured by echocardiography.ResultsIn total, 114 patients were enrolled. The mean age was 50 years, and the median dialysis duration was 33 months. Sixty‐one patients were men, and 24 were diabetic. LVMI decreased from 116.18 ± 27.84 to 110.70 ± 25.74 g/m2 in the roxadustat group. However, it increased from 109.35 ± 23.41 to 114.99 ± 28.46 g/m2 in the EPO group, with a significant difference in the change in LVMI between the two groups [−5.48 (−11.60 to 0.65) vs. 5.65 (0.74 to 10.55), p < 0.05]. Changes in left ventricular mass, end‐diastolic volume and 6‐min walk test seemed superior in the roxadustat group. There were no significant differences in other cardiac geometry, biochemical parameters and major adverse cardiovascular events between the two groups.ConclusionsCompared to EPO, roxadustat is more helpful in the regression of LVH in HD patients.

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Section: Discussionmentioning

confidence: 97%

Roxadustat reduces left ventricular mass index compared to rHuEPO in haemodialysis patients in a randomized controlled trial

Tan,

Wang,

Sun

et al. 2024

J Intern Med

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“…These results, and the results of similar animal investigations [60], highlight the important role of testosterone in LVM hypertrophy. In human studies, serum testosterone levels correlate with LVM/BSA in older women [61]. Similarly, exogenous testosterone administration is typically associated with LVM hypertrophy [62], though this is not a universal finding [63].…”

Section: Discussionmentioning

confidence: 98%

Inverse Association between Exercising Blood Pressure Response and Left Ventricular Chamber Size and Mass in Women Who Habitually Resistance Train

Matthews,

Guers,

Ramick

et al. 2024

Healthcare

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Exercise is a major modifiable lifestyle factor that leads to temporarily increased systolic blood pressure (SBP), which is thought to influence left ventricular mass normalized to body surface area (LVM/BSA). This relationship has never been studied in women who habitually perform resistance exercise. Purpose: To determine if a direct correlation exists between the SBP response to resistance exercise (change from rest; eSBP) and LVM/BSA in young healthy women who habitually resistance train. Methods: Leg extension resistance exercise was performed while continuously monitoring blood pressure using finger plethysmography. LVM was estimated using echocardiography. Data are shown as mean ± SD. Results: Thirty-one women participated (age 23 ± 3 years, height 164 ± 7 cm, body mass 63.7 ± 10.3 kg). Resting SBP (110 ± 8 mmHg, r = 0.355, p = 0.049) was shown to be directly correlated to LVM/BSA (72.0 ± 28.4 g/m2). Conversely, eSBP (30.8 ± 14.6 ∆mmHg, r = −0.437, p = 0.014) was inversely related to LVM/BSA. eSBP was not correlated to interventricular septum width (0.88 ± 0.12 cm, r = −0.137, p = 0.463) or posterior wall thickness (0.91 ± 0.15 cm, r = −0.084, p = 0.654). eSBP was inversely related to left ventricle internal diameter during diastole (LVIDd) (4.25 ± 0.33 cm, r = −0.411, p = 0.021). Conclusion: Counter to the hypothesis, these data suggest an inverse association between eSBP during resistance exercise and LVM/BSA in healthy young women who resistance train. This relationship is due to a smaller LVIDd with greater eSBP.

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“…The current clinical use of testosterone in the treatment of invasive breast cancer in women has also achieved good e cacy [52] . Testosterone levels in women have also shown signi cant correlations with depression, cognitive function, and cardiovascular system diseases in women [53][54][55] . In addition, testosterone and estrogen have important effects on glucose metabolism regulation [56][57][58][59] .…”

Section: Discussionmentioning

confidence: 99%

Association Between Sex Hormones Levels and Cancer Prevalence in Women, Especially Breast Cancer

Zhao,

Zhang,

Sun

et al. 2024

Preprint

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Background Estradiol and testosterone are the two most important sex hormones in the human body. Previous studies have shown that these two sex hormones have a certain relationship with the prevalence of cancer. In this study, we included a total of 3532 female subjects, the number of cancer was 366, which is 10.36% of the total study population, and the number of breast cancer was 97, with a prevalence of 2.75%. Methods Subject data were analyzed using logistic regression analysis, WQS and qgcomp analysis. Measures in the demographic characteristics data were described as mean (SD) to describe the distribution, and t-tests were used to determine differences between groups. Count data were expressed as N (%), and the chi-square test was used to determine differences between groups. The determining factor in the process of determining the critical value of ROC is the Yoden index.The point where the ROC index is maximum serves as the optimal cutoff point for the continuum variable. Results The results of multifactorial logistic regression analysis showed a negative correlation between testosterone levels and cancer prevalence, and a negative correlation between estradiol levels and breast cancer prevalence. Cancer prevalence and breast cancer prevalence were both lower in people with high estradiol and testosterone levels. Each quartile increase in the WQS index was associated with a 24% (OR:0.76,95% CI:0.63–0.91) reduction in the risk of cancer, and a 35% (OR:0.65,95% CI:0.44–0.96) reduction in the risk of breast cancer. Each quartile increase in the qgcomp index was associated with a 17% (OR:0.83,95%CI:0.70–0.97) reduction in cancer risk and a 39% (OR:0.61,95%CI:0.44–0.84) reduction in breast cancer risk. Conclusion Serum testosterone levels were more significantly and negatively correlated with cancer prevalence in women. Serum estradiol levels were more significantly and negatively correlated with breast cancer prevalence.

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Serum testosterone level correlates with left ventricular hypertrophy in older women

Cited by 4 publications

References 58 publications

Roxadustat reduces left ventricular mass index compared to rHuEPO in haemodialysis patients in a randomized controlled trial

Roxadustat reduces left ventricular mass index compared to rHuEPO in haemodialysis patients in a randomized controlled trial

Inverse Association between Exercising Blood Pressure Response and Left Ventricular Chamber Size and Mass in Women Who Habitually Resistance Train

Association Between Sex Hormones Levels and Cancer Prevalence in Women, Especially Breast Cancer

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