Serum thyroglobulin in differentiated thyroid carcinoma: histological and metastatic classification

Shah, D.H.; Dandekar, S. R.; Jeevanram, R.K.; Kumar, Ajay; Sharma, S.; Ganatra, R. D.

doi:10.1530/acta.0.0980222

Cited by 26 publications

(13 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Peculiar Tg levels could be seen in our patients with metastases. Like Shah et al [ 17] we observed higher Tg concentrations in the metastases of follicular thyroid carcinomas than in the papillary ones. The lower values in the latter were irrespective of the metastatic sites.…”

Section: Discussionsupporting

confidence: 83%

Postoperative Thyroglobulin Level Determination to Follow Up Patients with Highly Differentiated Thyroid Cancer

et al. 1989

View full text Add to dashboard Cite

The highly differentiated thyroid tumours account for 0.80% of all human malignancies. The papillary and follicular tumour tissues of this tumour type are relatively benign, hormone-dependent and beside their treatment specificity they secrete the tumour-specific thyroglobulin. This it becomes possible to follow the development of metastases, the effectiveness of therapy applied as well as the history of the disease. The authors studied the change of thyroglobulin level in 153 patients with highly differentiated thyroid cancer. In 29 of 32 metastatic patients a pathologically elevated (70–100 ng/ml) thyroglobulin level was observed. This proves the 91% specificity of the method in verified metastatic tumours. Compared to the total body scintigraphy 3 false-negative and 6 false-positive cases were found. The authors establish that, irrespective of the site of metastasis, the thyroglobulin level is higher in the follicular than in the papillary subtype. It is concluded that the measurement of the serum thyroglobulin level is a suitable marker of the highly differentiated thyroid cancer since it indicates local recurrence or distant metastases by a significant increase while therapy-resultant tumour diminution is accompanied by a marked decrease.

show abstract

Section: Discussionsupporting

confidence: 83%

Postoperative Thyroglobulin Level Determination to Follow Up Patients with Highly Differentiated Thyroid Cancer

et al. 1989

View full text Add to dashboard Cite

show abstract

“…Not all patients had total thyroidectomy or information missing Tubiana et al, 1985;Harvey et al, 1990;Schlumberger et al, 1991; Jadvar et al, 1998 Not all patients had radioiodine ablation or information missing Shlossberg et al, 1979;Shah et al, 1981;Echenique et al, 1982;Tubiana et al, 1985;Black et al, 1987;Schlumberger et al, 1988;Brendel et al, 1990;Black & Sheppard, 1991;Ruiz-Garcia et al, 1991;Dadparvar et al, 1993; Ladenson et al, 1997;Ruter et al, 1998; Ladenson, 2000;Ng et al, 2000;Sisson et al, 2000;Vitale et al, 2002 Tg cut-off values not indicated Dadparvar et al, 1993; Bejarano et al, 2000; Ladenson, 2000 Criteria for tumour missing Ng Tang Fui et al, 1979;Eber et al, 1980; Bednar et al, 1983;Schlumberger et al, 1988;Rubello et al, 1990;Grunwald et al, 1997; Ladenson et al, 1997;Roelants et al, 1997;Lin et al, 1998;Almeida-Filho et al, 2000;Fugazzola et al, 2002 Patients with Tg antibodies not excluded or information missing Bednar et al, 1983;Feldt-Rasmussen et al, 1983;Edmonds & Willis, 1988;Schlumberger et al, 1991;Meier et al, 1994;Feine et al, 1996;Roelants et al, 1997;Ruter et al, 1998;Grunwald et al, 1999;Seabold et al, 1999;de Klerk et al, 2000;Ng et al, 2000;Rubello et al, 2000;…”

Section: Appendixmentioning

confidence: 99%

Diagnostic value of serum thyroglobulin measurements in the follow‐up of differentiated thyroid carcinoma, a structured meta‐analysis

Eustatia‐Rutten¹,

Smit²,

Romijn³

et al. 2004

Clinical Endocrinology

169

View full text Add to dashboard Cite

show abstract

“…Tg in the hypothyroid condition has been established as a sensitive tumor marker, 30,31 especially when measured by the most up-to-date assays. Detectable or elevated levels of thyroglobulin indicate persistent, recurrent or metastatic disease.…”

Section: Patientsmentioning

confidence: 99%

Thyroid carcinoma in children and adolescents. Presentation, clinical course, and outcome of therapy in 23 children and adolescents in Northern Greece

Pazaitou‐Panayiotou¹,

Kaprara²,

Boudina³

et al. 2005

View full text Add to dashboard Cite

OBJECTIVE: To define clinical presentation, surgical complications, follow-up characteristics, and survival of 23 children and adolescents with thyroid carcinoma. DESIGN: Retrospective analysis of data of 23 children and adolescents with thyroid carcinoma cared for in the Theagenion Cancer Hospital, Thessaloniki. RESULTS: At the time of diagnosis cervical lymph node metastases were present in 18 (78.2%), mediastinal in 2 (8.69%), and pulmonary in 3 patients (13%). Total thyroidectomy was performed in 21 patients, with lymph node dissection in 18 and subtotal thyroidectomy in 2. No significant post-operative complications were observed. Histological examination revealed differentiated thyroid carcinoma (DTC). Tumor was multifocal in 11 (47.8%) and bilateral in 7 subjects (63.6%). Thyroid capsule invasion, vascular invasion, soft tissue involvement, and parathyroid gland invasion was observed in 12 out of 23 patients (52.1%). All patients received thyroxine suppressive therapy and 21 of them additional therapy with radioactive iodine ( 131 I). During follow-up (5.5 years), 6 out of the 23 patients presented new metastases in the cervical and mediastinal lymph nodes, lungs, and bones. At last follow-up, 11 patients (47.8%) had residual disease but all were alive. CONCLUSIONS: Thyroid carcinoma in children and adolescents can be quite aggressive. When a young patient presents thyroid nodule or multinodular goiter or palpable lymph nodes, the existence of thyroid carcinoma must be seriously considered.

show abstract

Serum thyroglobulin in differentiated thyroid carcinoma: histological and metastatic classification

Cited by 26 publications

References 0 publications

Postoperative Thyroglobulin Level Determination to Follow Up Patients with Highly Differentiated Thyroid Cancer

Postoperative Thyroglobulin Level Determination to Follow Up Patients with Highly Differentiated Thyroid Cancer

Diagnostic value of serum thyroglobulin measurements in the follow‐up of differentiated thyroid carcinoma, a structured meta‐analysis

Thyroid carcinoma in children and adolescents. Presentation, clinical course, and outcome of therapy in 23 children and adolescents in Northern Greece

Contact Info

Product

Resources

About