Serum Total Sialic Acid Level is Elevated in Hypothyroid Patients as an Atherosclerotic Risk Factor

Abstract

Sialic acid level is elevated in hypothyroid patients. However, this elevation is not related to thyroid hormone levels and autoantibodies. Correlations between SA and atherosclerosis indicators, such as CIMT, LDL, hs-CRP, and uric acid, in hypothyroid individuals suggest that SA may be an indicator of atherogenesis in these patients.

Correlation of serum N-Acetylneuraminic acid with the risk and prognosis of acute coronary syndrome: a prospective cohort study

“…However, the mechanism of its role in CAD has not been fully understood. At present, it is suggested that plasma Neu5Ac may promote the formation of atherosclerosis through enhancing the inflammatory reaction, disrupting iron metabolism, promoting platelet thrombosis and other mechanisms [34,35]. Moreover, the level of plasma Neu5Ac may be related to the severity of CHD, and the release of a large amount of intracellular and cell surface Neu5Ac into the blood at the early stage of MI is considered to be the main cause of the increased serum Neu5Ac level in these patients [19].…”

Sialic Acid As A Potential Biomarker for Cardiovascular Disease, Diabetes and Cancer

“…[21] A further study also suggested a link between sialic acid and CIMT, as well as other factors: low density lipoprotein (LDL), hs-CRP and uric acid. [22] Other studies probing sialic acid as a marker for CVD have shown a good correlation between controls and disease cohorts with different levels of vessel disease, indicating greater severity of atherosclerosis. [23,24] Patients with 1, 2 or 3 vessel disease (VD) had higher levels of serum TSA than controls.…”

Der Tumormarker Sialinsäure

“…Untersuchungen haben gezeigt, dass sich Sialinsäure im Speichel als Biomarker zur Diagnostik von Ovarialkarzinomen eignen kann [1,2,4,6].…”