Serum type I collagen breakdown product (serum CTX) predicts hip fracture risk in elderly women:

Chapurlat, R.; Garnero, Patrick; Brárt, G; Meunier, Pierre J.; Delmas, Pierre D.

doi:10.1016/s8756-3282(00)00325-2

Cited by 153 publications

(97 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Also, biochemical markers of bone turnover have been used to predict forthcoming fractures [9][10][11][12][13][14][15][16][17]. In particular, high levels of resorption markers, such as S-CTX [12] and S-TRACP5b [19], have been associated with such fractures.…”

Section: Discussionmentioning

confidence: 99%

“…Biochemical markers of bone turnover have been used for prediction of fracture, by us and by others [9][10][11][12][13][14][15][16][17][18][19]. If baseline levels of these markers would be influenced in either direction by recently or non-recently sustained fracture, such an event would introduce a possible bias, to be controlled for in further studies on prediction of fracture by biochemical markers.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Biochemical markers of bone turnover are influenced by recently sustained fracture

Obrant

Ivaska

Gerdhem

et al. 2005

Bone

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Biochemical markers of bone turnover are influenced by recently sustained fracture

Obrant

Ivaska

Gerdhem

et al. 2005

Bone

View full text Add to dashboard Cite

“…Several studies have shown that bone turnover may be an independent predictor of fracture risk [86][87][88][89][90] . In a study of 671 postmenopausal women, 116 of whom had fractures, high levels of the bone turnover marker bone-specific alkaline phosphatase were independently associated with an increased fracture risk, with an ageadjusted hazard ratio of 2.2 (range, 1.4 to 3.8).…”

Section: Prediction Of Fracture Riskmentioning

confidence: 99%

The Assessment of Fracture Risk

Unnanuntana

Gladnick

Donnelly

et al. 2010

The Journal of Bone and Joint Surgery-American Volume

316

207

View full text Add to dashboard Cite

Bone mineral density is considered to be the standard measure for the diagnosis of osteoporosis and the assessment of fracture risk. The majority of fragility fractures occur in patients with bone mineral density in the osteopenic range.ä The Fracture Risk Assessment Tool (FRAX) can be used as an assessment modality for the prediction of fractures on the basis of clinical risk factors, with or without the use of femoral neck bone mineral density. Treatment of osteoporosis should be considered for patients with low bone mineral density (a T-score of between 21.0 and 22.5) as well as a ten-year risk of hip fracture of ‡3% or a ten-year risk of a major osteoporosis-related fracture of ‡20% as assessed with the FRAX.ä Biochemical bone markers are useful for monitoring the efficacy of antiresorptive or anabolic therapy and may aid in identifying patients who have a high risk of fracture.ä An approach combining the assessment of bone mineral density, clinical risk factors for fracture with use of the FRAX, and bone turnover markers will improve the prediction of fracture risk and enhance the evaluation of patients with osteoporosis.

show abstract

“…The EPI DOS study has shown the re le van ce of ele va ted CTx le vels in pre dic ting se ve re cli ni cal events, such as hip frac tu res. 15 Her mann and Hermann hypot he si zed that ele va ted CTx con cen tra tions co uld be used to iden tify ath le tes at risk of os te o po ro sis and fu tu re frac tu res. 16 Des pi te be ing not sig ni fi cant, a 4% and 8% dec re a ses de ter mi ned in HIG and LIG, res pec ti vely, in this pre sent study might be the po si ti ve ef fect of re sis tan ce tra i ning when com pa red to the 2% in cre a se in CG.…”

Section: Bo Ne Tur No Ver Mar Kersmentioning

confidence: 99%

“…15,16 The re cent dis co very of the os te op ro te gerin (OPG)-TNF-α-re cep tor an ta go nist li gand (RANKL) system pro vi des furt her in sight in to the re gu la ti on of the equ i lib ri um bet we en os te ab lasts and os te oc lasts. [17][18][19][20][21] Re cep tor ac ti va tor of nuc le ar fac tor kap pa β (RANK) in du ces the dif fe ren ti a ti on of os te oc lasts, en han ces the ac ti vity of ma tu re os teoc lasts, and in hi bits os te oc last apop to sis by bin ding to its func ti o nal re cep tor, RANK, which is ex pressed on os te oc lasts or the ir pro ge ni tors.…”

mentioning

confidence: 99%

Effects of Different Intensity Resistance Exercise Programs on Bone Turnover Markers, Osteoprotegerin and Receptor Activator of Nuclear Factor Kappa Β Ligand in Post-Menopausal Women

Karaarslan¹,

Büyükyazi²,

Taneli³

et al. 2010

Turkiye Klinikleri J Med Sci

View full text Add to dashboard Cite

A AB BS S T TR RA AC CT T O Ob b j je ec c t ti i v ve e: : To in ves ti ga te the ef fects of 12-we ek two-dif fe rent in ten sity re sis tan ce tra i ning prog rams on bo ne tur no ver mar kers, bo ne mi ne ral den sity (BMD), os te op ro to ge rin (OPG), and so lub le recep tor ac ti va tor of nuc le ar fac tor kap pa β li gand (sRANKL) in post me no pa u sal wo men. M Ma a t te e r ri i a al l a an nd d M Me et t --h ho od ds s: : Forty he althy wo men (aged 45-60 ye ars) par ti ci pa ted in the study. High-in ten sity gro up (HIG; n=14) wor ked 4 days a we ek and per for med two sets of 8-10 re pe ti ti ons at ~70-80% of 1 re pe at ma xi mum (RM). Low-in ten sity gro up (LIG; n= 13) wor ked in the sa me du ra ti on, with 13-17 re pe ti ti ons, at ~40-50% of 1RM. Con trol gro up (CG; n = 13) did not per form any exer ci ses. Body com po si ti on, 1RM va lu e for 10 exer ci ses, re pe ti ti ons of sit-ups for 30 se conds, bo ne for ma ti on and re sorp ti on mar kers, se rum os te o cal ci ne (OC), bone al ka li ne phosp ha ta se (BAP), βCross Labs, OPG, and sRANKL le vels we re me a su red be fo re and af ter the tra i ning prog ram. BMD was me a su red vi a du al energy X-ray ab sorp ti o metry. R Re e s su ul lt ts s: : Re sis tan ce tra i ning ca u sed in cre a ses in spi ne BMD in HIG and LIG (p< 0.05), and OC le vels in cre a sed in the HIG (p< 0.05). We ob ser ved a sig ni fi cant dif fe ren ce bet we en the per cent chan ge in HIG ver sus the per cent chan ge in CG in the spi ne BMD va lu es (p< 0.01). sRANKL le vels dec re a sed sig ni fi cantly in all three gro ups. Strength me asu res in cre a sed in both exer ci se gro ups (p< 0.001), fa vo ring the HIG. C Co on nc c l lu u s si i o on n: : High-in ten sity re sis tance tra i ning may be mo re ef fec ti ve for in cre a sing musc le strength and pro tec ting aga inst os te o po ro sis and frac tu res. Du e to in sig ni fi cant chan ges in OPG le vels and sig ni fi cant re duc ti ons in sRANKL in all gro ups, me a su res of cir cu la ting OPG and sRANKL le vels se em not to be so use ful to pre dict BMD or bo ne tur nover sta tus af ter re sis tan ce tra i ning prog rams. The re fo re, the se pa ra me ters re ma in to be de ter mi ned di rectly in the bo ne mic ro en vi ron ments to get her with BMD me a su res and bo ne tur no ver mar kers.K Ke ey y W Wo or rd ds s: : Os te o po ro sis, post me no pa u sal; RANK li gand; os te op ro te ge rin Ö ÖZ ZE ET T A Am ma aç ç: : İki fark lı yük len me şid de tin de ya pı lan 12 haf ta lık di renç an tren man prog ram la rı nın postme ne po zal dö nem de ki ka dın la rın, ke mik tur no ver mar ker le ri, ke mik mi ne ral yo ğun lu ğu (KMY), os te opro ge rin (OPG) ve so lub le nük le er fak tör kap pa Β re sep tör ak ti va tör li gan dı (sRANKL) üze ri ne olan et ki si ni be lir le mek. G Ge e r re eç ç v ve e Y Yö ön n t te em m l le er r: : Post-me no poz dö nem de ki 40 sağ lık lı ka dın (45-60 yaş) ça lış ma ya ka tıl -dı. Yük sek şid det gru bu (YŞG; n= 14) haf ta da 4 gün, 1 tek rar mak si mu mun (TM)...

show abstract

Serum type I collagen breakdown product (serum CTX) predicts hip fracture risk in elderly women:

Cited by 153 publications

References 28 publications

Biochemical markers of bone turnover are influenced by recently sustained fracture

Biochemical markers of bone turnover are influenced by recently sustained fracture

The Assessment of Fracture Risk

Effects of Different Intensity Resistance Exercise Programs on Bone Turnover Markers, Osteoprotegerin and Receptor Activator of Nuclear Factor Kappa Β Ligand in Post-Menopausal Women

Contact Info

Product

Resources

About