Serum Type IV Collagen in Diabetic Patients at Risk for Nephropathy

Cohen, Morrel H.; Shearman, Clyde W.; Lautenslager, Gregory T.

doi:10.2337/diacare.24.8.1324

Cited by 13 publications

(8 citation statements)

References 32 publications

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“…In addition, urine levels of collagen IV correlate with glomerular matrix accumulation and declining renal function in animal models of kidney disease 71 . In contrast, serum levels of collagen IV are not associated with the development of renal injury or loss of kidney function 72 …”

Section: Biomarkers Of Renal Fibrosismentioning

confidence: 99%

Review: Serum and urine biomarkers of kidney disease: A pathophysiological perspective

Tesch

2010

Nephrology

121

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The use of reliable biomarkers is becoming increasingly important for the improved management of patients with acute and chronic kidney diseases. Recent developments have identified a number of novel biomarkers in serum or urine that can determine the potential risk of kidney damage, distinguish different types of renal injury, predict the progression of disease and have the potential to assess the efficacy of therapeutic intervention. Some of these biomarkers can be used independently while others are more beneficial when used in combination with knowledge of other clinical risk factors. Advances in gene expression analysis, chromatography, mass spectrometry and the development of sensitive enzyme-linked immunosorbent assays have facilitated accurate quantification of many biomarkers. This review primarily focuses on describing new and established biomarkers, which identify and measure the various pathophysiological processes that promote kidney disease. It provides an overview of some of the different classes of renal biomarkers that can be assessed in serum/plasma and urine, including markers of renal function, oxidative stress, structural and cellular injury, immune responses and fibrosis. However, it does not explore the current status of these biomarkers in terms of their clinical validation.

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Section: Biomarkers Of Renal Fibrosismentioning

confidence: 99%

Review: Serum and urine biomarkers of kidney disease: A pathophysiological perspective

Tesch

2010

Nephrology

121

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“…Increased in serum (Watanabe T. et al 1991;Xu et al 2002) and urine (Watanabe T. et al 1991;Kotajima et al 2000;Watanabe H. et al 2000;Cohen et al 2001;Tashiro et al 2004) Increased in serum (Yoneda et al 2007)…”

Section: Type IV Collagenmentioning

confidence: 99%

Fibrosis in diabetes complications: Pathogenic mechanisms and circulating and urinary markers

Ban

Twigg

2008

VHRM

216

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Diabetes mellitus is characterized by a lack of insulin causing elevated blood glucose, often with associated insulin resistance. Over time, especially in genetically susceptible individuals, such chronic hyperglycemia can cause tissue injury. One pathological response to tissue injury is the development of fi brosis, which involves predominant extracellular matrix (ECM) accumulation. The main factors that regulate ECM in diabetes are thought to be pro-sclerotic cytokines and protease/anti-protease systems. This review will examine the key markers and regulators of tissue fi brosis in diabetes and whether their levels in biological fl uids may have clinical utility.

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“…the appearance of microalbuminuria [1,2]. Type IV collagen (COL) is the primary component of the GBM and mesangial matrix, and a small amount of COL is exncreted into the urine in healthy subjects, although its main origin is not fully clear [3][4][5][6]. Moreover, urinary type IV collagen (U-COL) excretion is less susceptible to physiological changes than urinary albumin (Alb) is [4,7].…”

Section: Introductionmentioning

confidence: 99%

Urinary type IV collagen excretion predicts an increased urinary albumin-to-creatinine ratio in normoalbuminuric patients with diabetes

Ogawa

Matsushima²,

Okamura³

et al. 2012

JDM

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Aims: We evaluated whether urinary excretion of type IV collagen (U-COL) may predict an increase in the urinary albumin-to-creatinine ratio (ACR) and what factors regulate U-COL in 145 normoalbuminuric patients with type 2 diabetes. Methods: We measured HbA1c, systolic blood pressure (SBP), urinary 8-hydroxydeoxyguanosine (8-OHdG) and monocyte chemoattractant protein (MCP)-1 at start of this study (Baseline), ACR and U-COL in addition to these measurements at one year later (Evaluation-1), and ACR and SBP after two years of the Evaluation-1 (Evaluation-2). The relationships were investigated between the increase of ACR and the U-COL. The effect of angiotensin receptor blockers (ARB) treatment on the correlations between U-COL and ACR at Evaluation-2 on one hand, and between U-COL and percent change of ACR on the other, was also analyzed. Furthermore, we investigated whether the increase in 8-OHdG and in MCP-1 in a year prior to the Evaluation-1 were risk factors of the rise in U-COL levels. Results: Both U-COL and SBP at Evaluation-1, but not ARB treatment, were independent risk factors for an increased ACR after 2 years. ARB treatment significantly suppressed the increase in ACR after 2 years in patients with higher U-COL excretion. The percentage changes in 8-OHdG (%8-OHdG) and MCP-1 (%MCP-1) in one year prior to Evaluation-1 measurements are independent risk factors for U-COL. HbA1c and SBP values one year prior to Evaluation-1 are independent risk factors not only for %8-OHdG but also, for baseline U-COL. The %8-OHdG is an independent risk factor for %MCP-1. Conclusions: U-COL may predict an increase in the ACR. The U-COL seems to be increased with oxidative stress and inflammation induced by past hyperglycemia

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Serum Type IV Collagen in Diabetic Patients at Risk for Nephropathy

Cited by 13 publications

References 32 publications

Review: Serum and urine biomarkers of kidney disease: A pathophysiological perspective

Review: Serum and urine biomarkers of kidney disease: A pathophysiological perspective

Fibrosis in diabetes complications: Pathogenic mechanisms and circulating and urinary markers

Urinary type IV collagen excretion predicts an increased urinary albumin-to-creatinine ratio in normoalbuminuric patients with diabetes

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