Serum uric acid and the risk of gestational diabetes mellitus: a systematic review and meta-analysis

Su, Shaofei; Zhang, Enjie; Gao, Shen; Zhang, Yue; Liu, Jianhui; Xie, Shuanghua; Yue, Wentao; Liu, Ruixia; Yin, Chenghong

doi:10.1080/09513590.2023.2231101

Cited by 3 publications

(1 citation statement)

References 49 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Similarly, it is an important predisposing factor for gestational insulin resistance (IR) and increases the risk of GDM 10 . Also a recent meta-analysis conducted on confirmed the role of serum acid uric as a potential independent risk factor for gestational diabetes mellitus (GDM) 11 . In a study including 24,023 pregnant women 12 , 3204 (13.44%) had GDM diagnosed between weeks 24 and 28 of pregnancy.…”

Section: Discussionmentioning

confidence: 93%

New perspective on first-trimester serum uric acid level in predicting the risk of gestational diabetes mellitus

Li,

Niu,

Bai

et al. 2024

Sci Rep

View full text Add to dashboard Cite

This study aimed to investigate the correlation between serum uric acid (UA) and gestational diabetes mellitus (GDM) during the first trimester and provide a new perspective for the prevention and treatment of GDM. Based on the diagnostic criteria of gestational diabetes of the International Association of Diabetes and Pregnancy Study Groups, 1744 and 4256 patients were enrolled in the GDM and normal glucose tolerance (NGT) groups. Four groups were constituted based on the quartile of first-trimester serum UA (UA) level, and the differences in each indicator between groups were compared. Logistic regression was used to analyze the effects of UA level on GDM risk. The rate of GDM in the UA quartile changed from low to high. Significant differences were also observed in fasting plasma glucose level, 1 h post glucose and 2 h post glucose levels, in all the groups (P < 0.05), which increased with the UA level. UA level were independent risk factors for GDM. The best threshold of GDM predicted by the first-trimester UA level was 226.55 μmol/L. The first-trimester UA level in patients with GDM was relatively higher and was an independent risk factor for GDM.

show abstract

Section: Discussionmentioning

confidence: 93%