Serum uric acid as a novel marker for uterine atony and post-spinal vasopressor use during cesarean delivery

Kovacheva, Vesela; Soens, Mieke A.; Tsen, Lawrence C.

doi:10.1016/j.ijoa.2013.04.005

Cited by 7 publications

(2 citation statements)

References 51 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Our results are similar to study done by Kochapava et al [24] who studied the relation between elevated serum uric acid level and vasopressor use in patients undergoing neuraxial anaesthesia for caesarean delivery and found that elevated serum uric acid in parturients is associated with decreased use of post spinal vasopressors. [24] The results of our study are also the same as the study conducted by Bhatia N et al [25] They studied the effect of maternal hyperuricemia on postspinal hypotension in normotensive parturients undergoing non elective caesarean delivery in a prospective observational study and observed that elevated serum uric acid levels were associated with lower incidence of post spinal hypotension and reduced need of vasopressors to maintain blood pressure within a normal range. [25] Limitations Serum UA levels can increase with food intake, which was not controlled in our study.…”

Section: Discussionsupporting

confidence: 92%

Effect of maternal hyperuricemia on post-spinal hypotension in preeclamptic parturients undergoing elective cesarean delivery: a prospective observational study

Gani¹,

Kashmir²

2020

jmscr

View full text Add to dashboard Cite

Serum Uric acid (UA) is a marker of oxidative stress in preeclampsia. Hyperuricemia has been shown to be associated with impaired vascular relaxation in some retrospective studies. Elevated uric acid is also an independent predictor of hypertension. This study is designed to study the association between elevated serum uric acid levels and post spinal hypotension in pregnancy induced hypertension patients undergoing elective caesarean delivery under spinal anesthesia, as measured by requirement of vasopressors. Materials and Methods: 204 patients with pregnancy induced hypertension scheduled for elective caesarean section under spinal anesthesia were included in the study. Demographic data, anesthetic management and peripartum course were recorded. Serum uric levels were measured on arrival to operation theatre. Doses of vasopressor agents required after spinal anesthesia was recorded. The association between serum uric acid level and requirement of vasopressor was studied. Data was analysed using students t test and chisquare test. P-value<0.05 was considered significant. Results and Observations: Requirement of vasopressors was lower in patients with high serum uric acid levels than those with lower serum uric acid levels. Results were similar with both phenylephrine and ephedrine. The difference in vasopressor requirement was statistically significant.(p-value<0.05) Conclusion: Elevated serum uric acid levels are inversely related to development of post spinal hypotension and requirement of vasopressors in preeclamptic patients undergoing cesarean section under spinal anesthesia.

show abstract

Section: Discussionsupporting

confidence: 92%

Effect of maternal hyperuricemia on post-spinal hypotension in preeclamptic parturients undergoing elective cesarean delivery: a prospective observational study

Gani¹,

Kashmir²

2020

jmscr

View full text Add to dashboard Cite

show abstract

“…По мнению V. Kovacheva и соавт. [13], окислительный стресс считается существенным фактором развития ПЭ, а концентрация мочевой кислоты в сыворотке крови может быть предложена в качестве подходящего маркера для определения тяжести этого стресса. Во-первых, активные формы кислорода могут вызывать апоптоз синцитиотрофобласта (STBM) во время процесса плацентации и нарушить нормальное ремоделирование артериол.…”

Section: мочевая кислота -«новый» старый маркер преэклампсии и ее ослunclassified

Uric acid as an old 'new' marker of preeclampsia and its commplications (a review)

Navolockaya¹,

Lyashko²,

Shifman³

et al. 2018

Probl. reprod.

View full text Add to dashboard Cite

академия им. С.И. Георгиевского» Крымского федерального университета им. В.И. Вернадского, Симферополь, Россия В настоящем обзоре рассмотрены современные представления о роли мочевой кислоты в патогенезе преэклампсии, результаты исследования ее показателей при гипертензивных нарушениях, сопровождающих беременность, а также обоснование целесообразности использования мочевой кислоты в качестве маркера преэклампсии и ее осложнений. Изучение динамики показателей мочевой кислоты при гестационной гипертензии позволит выявить потенциальные возможности ранней диагностики преэклампсии и улучшить качество ее лечения.

show abstract

Maternal hyperuricemia as a marker of post-spinal hypotension and uterine tone during cesarean delivery: a prospective observational study

Bhatia

Shanmugam

Jain

et al. 2019

Arch Gynecol Obstet

View full text Add to dashboard Cite

Serum uric acid as a novel marker for uterine atony and post-spinal vasopressor use during cesarean delivery

Cited by 7 publications

References 51 publications

Effect of maternal hyperuricemia on post-spinal hypotension in preeclamptic parturients undergoing elective cesarean delivery: a prospective observational study

Effect of maternal hyperuricemia on post-spinal hypotension in preeclamptic parturients undergoing elective cesarean delivery: a prospective observational study

Uric acid as an old 'new' marker of preeclampsia and its commplications (a review)

Maternal hyperuricemia as a marker of post-spinal hypotension and uterine tone during cesarean delivery: a prospective observational study

Contact Info

Product

Resources

About