Serum uric acid in relation to serum 1,5-anhydroglucitol levels in patients with and without type 2 diabetes mellitus

Ouchi, Motoshi; Oba, Koji; Aoyama, Junya; Watanabe, Kentaro; Ishii, Kensuke; Yano, Hiroyuki; Motoyama, Masayuki; Sekimizu, Ken-ichi; Matsumura, Noriaki; Igari, Yoshimasa; Suzuki, Tatsuya; Nakano, Hiroshi

doi:10.1016/j.clinbiochem.2013.06.003

Cited by 14 publications

(12 citation statements)

References 27 publications

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“…In addition, we found via stepwise multiple regression analysis that serum UA was significantly and positively correlated with 1,5-AG, which is compatible to previous studies [17,18]. We suppose the reason may be that both serum uric acid and 1,5-AG concentrations are decreased in diabetic patients through the increase of their urinary excretion.…”

Section: Resultssupporting

confidence: 91%

Serum 1,5-Anhydroglucitol Concentrations Remain Valid as a Glycemic Control Marker In Diabetes with Earlier Chronic Kidney Disease Stages

Bai

Yang

Song

et al. 2017

Exp Clin Endocrinol Diabetes

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Section: Resultssupporting

confidence: 91%

Serum 1,5-Anhydroglucitol Concentrations Remain Valid as a Glycemic Control Marker In Diabetes with Earlier Chronic Kidney Disease Stages

Bai

Yang

Song

et al. 2017

Exp Clin Endocrinol Diabetes

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“…Previous research revealed that UA is related to serum 1,5‐AG in both the diabetic and nondiabetic population . Our research group also found that the values of 1,5‐AG had positive correlations to UA independently ( P < 0.01).…”

Section: Discussionsupporting

confidence: 80%

“…This is suspected to be due to the cotransporter of 1,5-AG and UA in renal tubules. 33 The high level of UA in renal tubules may inhibit the excretion of 1,5-AG, elevating serum 1,5-AG. 34,35 We did not find any differences between high-and low-UA groups in males, although this may result from the small sample size of high-UA males.…”

Section: Discussionmentioning

confidence: 99%

Reference intervals for serum 1,5‐anhydroglucitol of a population with normal glucose tolerance in Jiangsu Province

Chen

Wang

Tan

et al. 2020

Journal of Diabetes

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Background: Serum 1,5-anhydroglucitol (1,5-AG) is a new glycemic marker which can reflect glucose fluctuation over 3 to 7 days and is now increasingly used to monitor glucose control and to screen for diabetes. However, 1,5-AG has not been widely used in China due to lack of epidemiological support. Our study aims to establish the reference intervals for a population with normal glucose tolerance in Jiangsu Province and to explore the determinants of these intervals. Method:The study enrolled 646 healthy adults aged 20 to 70 years in Jiangsu Province in 2018 after oral glucose tolerance test. 1,5-AG, fasting and 2-hour glucose, UA, liver enzyme, serum lipid, creatinine, and glycosylated hemoglobin were measured. We calculated reference intervals using the parametric method and examined the relationship between 1,5-AG and influence factors.Results: The average age of the participants was 50.5 ± 9.0 years, and 69.5% of them were females. The reference intervals were 15.8 to 52.6 μg/mL for males and 14.3 to 48.0 μg/mL for females. Among females, the reference intervals were 13.9 to 45.3 and 14.6 to 49.6 μg/mL for menopausal and postmenopausal females, respectively. Males showed higher 1,5-AG concentrations than females, and postmenopausal females had higher 1,5-AG than menopausal females. There was a positive correlation between uric acid and 1,5-AG in both genders. Positive correlation between 1,5-AG and age was only observed in females. Conclusion:We established reference intervals for 1,5-AG in Jiangsu Province, and the level of 1,5-AG is affected by sex, uric acid, and age. Highlights• Males, menopausal females, and postmenopausal females had corresponding reference intervals for 1,5-anhydroglucitol (1,5-AG). • Levels of serum uric acid and age should be taken into consideration when interpreting 1,5-AG.

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“…13 A small number of studies demonstrated a strong positive correlation between serum UA and 1,5-AG levels. [14][15][16] Yamanouchi et al and the authors of the present study have shown negative associations between urinary NAG (U/L) levels, 17 urinary NAG-creatinine ratio levels 18,19 and serum 1,5-AG. From the results of these studies, we are unable to exclude the possibility that 1,5-AG was a mediator between the reduction in serum UA levels and treatment with SGLT2 inhibitors.…”

Section: Discussionsupporting

confidence: 52%

“…The level of serum 1,5‐anhydroglucitol (1,5‐AG) is believed to decrease in patients who received an SGLT2 inhibitor . A small number of studies demonstrated a strong positive correlation between serum UA and 1,5‐AG levels . Yamanouchi et al and the authors of the present study have shown negative associations between urinary NAG (U/L) levels, urinary NAG‐creatinine ratio levels and serum 1,5‐AG.…”

Section: Discussionsupporting

confidence: 51%

Uric acid lowering in relation to HbA1c reductions with the SGLT2 inhibitor tofogliflozin

Ouchi

Oba²,

Kaku

et al. 2018

Diabetes Obesity Metabolism

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An integrated analysis was performed with data from 4 phase 2 and phase 3 studies of tofogliflozin in which patients with type 2 diabetes mellitus received the sodium‐glucose cotransporter 2 inhibitor tofogliflozin for up to 24 weeks. Sex differences, baseline haemoglobin A1c (HbA1c) and serum uric acid (UA) levels, and log10‐transformed urinary N‐acetyl‐β‐D‐glucosaminidase ratio were significantly correlated with the reduction in serum UA levels at both 4 and 24 weeks in multivariate analysis (respectively, P < .0001). The decrease in HbA1c levels was greatest in the group with the highest baseline HbA1c level (quartile 4; HbA1c > 8.6%) and lowest in the group with the lowest baseline HbA1c level (quartile 1; HbA1c ≤ 7.4%). The decrease in serum UA levels was greatest in the quartile 1 group and lowest in the quartile 4 group. In most groups, the maximum decrease in serum UA levels was seen in the first 4 weeks, while the maximum decrease in HbA1c was seen at week 24. Thus, serum UA levels were significantly decreased in patients with moderate HbA1c levels.

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Serum uric acid in relation to serum 1,5-anhydroglucitol levels in patients with and without type 2 diabetes mellitus

Cited by 14 publications

References 27 publications

Serum 1,5-Anhydroglucitol Concentrations Remain Valid as a Glycemic Control Marker In Diabetes with Earlier Chronic Kidney Disease Stages

Serum 1,5-Anhydroglucitol Concentrations Remain Valid as a Glycemic Control Marker In Diabetes with Earlier Chronic Kidney Disease Stages

Reference intervals for serum 1,5‐anhydroglucitol of a population with normal glucose tolerance in Jiangsu Province

Uric acid lowering in relation to HbA1c reductions with the SGLT2 inhibitor tofogliflozin

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