Serum uric acid. Its relationship to coronary heart disease risk factors and cardiovascular disease, Evans County, Georgia

Is serum uric acid a risk factor for coronary heart disease?

“…[2][3][4][5][6][8][9][10][11][12]17 The question as to whether high disease which could confound the observed association. This review assesses the role of elevated serum uric acid as an independent role for coronary heart disease.…”

“…In the Evans County, Georgia study of 2530 subjects, the relationship between serum acid and CHD was not significant after adjustment for blood pressure and cardiovascular medication. 5 Several large studies have found the apparent association of uric acid with CHD to be related to diuretic use. 6,7 The Honolulu Heart Study, a study of over 7000 men, showed no correlation between uric acid and CHD after excluding men on diuretic therapy.…”

“…[1][2][3][4] However, hyperuricaemia has also been shown to be associated with many cardiovascular risk factors, in particular hypertension, pre-existing CHD, hyperlipidaemia and the use of antihypertensive treatment. [4][5][6][7][8][9][10][11] Thus the role of serum uric acid as an independent risk factor for CHD remains uncertain. Although earlier studies suggested uric acid to be an independent risk factor for CHD 1,2 there is now increasing evidence that the association of hyperuricaemia with CHD events is dependent on the association between uric acid and other cardiovascular risk factors.…”

“…Although earlier studies suggested uric acid to be an independent risk factor for CHD 1,2 there is now increasing evidence that the association of hyperuricaemia with CHD events is dependent on the association between uric acid and other cardiovascular risk factors. [3][4][5][6][8][9][10][11][12] Several investigators conclude that the association is explained by secondary associations of uric acid with hypertension, diuretic agents and elevated levels of tryglyceride. [3][4][5][6][8][9][10][11][12] It has also been postulated that hyperuricaemia may be part of the insulin resistance syndrome.…”

“…[3][4][5][6][8][9][10][11][12] Several investigators conclude that the association is explained by secondary associations of uric acid with hypertension, diuretic agents and elevated levels of tryglyceride. [3][4][5][6][8][9][10][11][12] It has also been postulated that hyperuricaemia may be part of the insulin resistance syndrome. [13][14][15][16] A number of investigators have suggested an independent role of uric acid on the risk of CHD in women but not in men.…”