Serum uric acid level in newly diagnosed essential hypertension in a Nepalese population: A hospital based cross sectional study

Poudel, Bibek; Yadav, Binod Kumar; Kumar, Arun; Jha, Bharat; Raut, K B

doi:10.1016/s2221-1691(14)60209-4

Cited by 26 publications

(23 citation statements)

References 26 publications

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“…This was similar to the findings by Poudel et al,15 who conducted a cross-sectional study of untreated hypertensive individuals in Nepal. It was found that hyperuricemia was more common among hypertensive patients when compared to the normotensive controls (28.8% versus 13.7%, respectively; P <0.001) 15. However, this prevalence was lower than the 46.9% rate found in the present study.…”

Section: Discussionsupporting

confidence: 92%

Serum uric acid and target organ damage in essential hypertension

Ofori¹,

Odia²

2014

VHRM

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BackgroundHypertension is a major risk factor for cardiovascular mortality, as it acts through its effects on target organs, such as the heart and kidneys. Hyperuricemia increases cardiovascular risk in patients with hypertension.ObjectiveTo assess the relationship between serum uric acid and target organ damage (left ventricular hypertrophy and microalbuminuria) in untreated patients with essential hypertension.Patients and methods: A cross-sectional study was carried out in 130 (85 females, 45 males) newly diagnosed, untreated patients with essential hypertension. Sixty-five healthy age- and sex-matched non-hypertensive individuals served as controls for comparison. Left ventricular hypertrophy was evaluated by cardiac ultrasound scan, and microalbuminuria was assessed in an early morning midstream urine sample by immunoturbidimetry. Blood samples were collected for assessing uric acid levels.ResultsMean serum uric acid was significantly higher among the patients with hypertension (379.7±109.2 μmol/L) than in the controls (296.9±89.8 μmol/L; P<0.001), and the prevalence of hyperuricemia was 46.9% among the hypertensive patients and 16.9% among the controls (P<0.001). Among the hypertensive patients, microalbuminuria was present in 54.1% of those with hyperuricemia and in 24.6% of those with normal uric acid levels (P=0.001). Similarly, left ventricular hypertrophy was more common in the hypertensive patients with hyperuricemia (70.5% versus 42.0%, respectively; P=0.001). There was a significant linear relationship between mean uric acid levels and the number of target organ damage (none versus one versus two: P=0.012).ConclusionThese results indicate that serum uric acid is associated with target organ damage in patients with hypertension, even at the time of diagnosis; thus, it is a reliable marker of cardiovascular damage in our patient population.

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Section: Discussionsupporting

confidence: 92%

Serum uric acid and target organ damage in essential hypertension

Ofori¹,

Odia²

2014

VHRM

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“…The prevalence of the hyperuricemia was 30.2% in our study, comparable with those noted in Cameroun [14] and Nepal [15], respectively of 31.8% and 28.8%, thus raising strong relationship between the HTN and the hyperuricemia.This fact is so obvious that the uricemia is listed among the WHO minimum assessment for the HTN. In the general population, this prevalence is much lower, lies between 14% -25% according to series' [16] [17] [18].…”

Section: Discussionsupporting

confidence: 85%

Hyperuricemia and Associated Factors during Arterial Hypertension in Brazzaville (Congo)

Ikama¹,

Matingou²,

Makani³

et al. 2019

WJCD

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A longitudinal analytical and comparative study including outpatients was carried between June 1 st and December 31 st 2017. The objectives were to determine the hyperuricemia frequency during arterial hypertension, to identify associated factors, and to evaluate its impact on the blood pressure control. We have included, hypertensive patients having a minimum blood test including at least an uricemia. They were divided into two groups according to whether they have presented a hyperuricemia (HU) or a normouricemia (NU). Among these 202 patients included, 61 (30.2%) presented a hyperuricemia. The mean age in HU group was 54.6 ± 11.6 years vs 53.6 ± 11 years for NU group (p = 0.573). Following cardiovascular risk factors were more found in the HU group than NU group: overweight/obesity (68.8% vs 46.1%; p = 0.003), metabolic syndrome (42.6% vs 39%; p = 0.021). Diuretics were used in 72.1% of patients in HU group vs 47.5% in NU group (p = 0.002). Bitherapy was used in 56% of the patients of HU group vs 69% in the NU group (p = 0.295), and the quadritherapy in 8% and 1% of the patients respectively (p = 0.049). Blood pressure was not controlled in 68.8% of HU group vs 48.9% in the NU group (p = 0.014). In multivariate analysis after logistic regression, factors associated with hyperuricemia were: glucose intolerance or diabetes (p = 0.004; OR = 1.35) and uncontrolled blood pressure (p = 0.006; OR = 2.51). This preliminary study showed that hyperuricemia is commonly found in hypertensive patients and has negative impact on blood pressure control.

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“…Significant high serum uric acid level in hypertensive patients were also observed by Eisen et al (26) and Grayson et al (27). The serum level of uric acid was associated with the incident of hypertension and may be important of developing hypertension (24).…”

Section: Discussionmentioning

confidence: 99%

Evaluation of uric acid levels as antioxidant during normal pregnancy and pregnancy with complication (diabetes and hypertension)

et al. 2018

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The uric acid is a waste product of the living cell, produced by xanthine oxidase, which contributes up to 60% of the total plasma antioxidant activity in healthy subjects. The study provides data relating serum uric acid, glucose levels and blood hypertension. Seventy nine patients with pregnancy diabetes mellitus, 25 normal healthy with pregnancy, 25 DM patients, and fifty normal healthy persons, where seen from February till July 2017, in Al-Semawa General Hospital, were participated in the study. The results revealed a highly significant difference (P<0.001) in uric acid, glucose level and hypertension in almost pregnancy diabetic patients and DM patients when compared to control group. In conclusion, this study found that pregnancy women at the early development stage of glucose disorders had a significantly of hyperuricemia and in clinical practices, measurement of serum uric acid level may help to identify the risk of hypertension.

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Serum uric acid level in newly diagnosed essential hypertension in a Nepalese population: A hospital based cross sectional study

Abstract: The mean serum uric acid levels and number of hyperuricemic subjects were found to be significantly higher in cases when compared to controls.

Cited by 26 publications

References 26 publications

Serum uric acid and target organ damage in essential hypertension

Serum uric acid and target organ damage in essential hypertension

Hyperuricemia and Associated Factors during Arterial Hypertension in Brazzaville (Congo)

Evaluation of uric acid levels as antioxidant during normal pregnancy and pregnancy with complication (diabetes and hypertension)

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