Serum uric acid levels and risk for acute ischaemic nonembolic stroke in elderly subjects

Milionis, Haralampos; Kalantzi, Kallirroi; Goudevenos, John; Seferiadis, K.; Mikhailidis, DP; Elisaf, Moses

doi:10.1111/j.1365-2796.2005.01565.x

Cited by 68 publications

(63 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In addition, in patients admitted with stroke, serum UA was an independent predictor of future cardiovascular events in the next 2 years [19]. Furthermore, a study showed that elevated UA was associated with an increased risk for acute stroke in elderly individuals [20]. A study in healthy postmenopausal women showed that serum UA levels, independently of other cardiovascular risk factors, were associated with intima-media thickness (IMT), a well known marker of cardiovascular disease [21].…”

Section: Discussionmentioning

confidence: 99%

Predictors of In-Hospital Mortality after Acute Ischemic Stroke in Subjects with and without Diabetes Mellitus

Papazafiropoulou¹,

Sotiropoulos²,

Skliros³

et al. 2009

TOGMJ

View full text Add to dashboard Cite

Abstract:Background: Diabetes mellitus is a well-established risk factor for ischemic stroke and is associated with increased in-hospital mortality. The aim of the present study was to determine the potential predictors of in-hospital mortality after an ischemic stroke in diabetic and nondiabetic subjects. Methods: 159 diabetic subjects (66 males / 93 females, mean age ± SD: 77.4 ± 6.4 years) and 159 non diabetic subjects (66 males / 93 females, mean age ± SD: 77.3 ± 5.2 years) hospitalized for ischemic stroke were studied. Demographic characteristics and laboratory tests on admission as well as outcome were recorded. Brain computed tomography scan was performed in all study subjects. Results: In-hospital death rates did not differ between the diabetic and the nondiabetic patients [36 (22.6%) vs. 27 (17.0%), respectively, P = 0.20]. In the diabetic study group multivariate analysis, after controlling for CRP, total cholesterol, LDL-C, urea and creatinine levels, demonstrated that death was related with WBC count (OR: 1.002, 95% CI: 1.001-1.004, P = 0.005), glucose levels (OR: 1.007, 95% CI: 1.002-1.012, P = 0.008), and UA levels (OR: 1.51, 95% CI: 1.003-2.260, P = 0.05). In the nondiabetic study group, after controlling for WBC count, CRP, total cholesterol and LDL-C levels, death was related only with glucose levels (OR: 1.016, 95% CI: 1.001-1.031, P = 0.03). Conclusions: WBC count and UA levels on hospital admission are independent predictors for in-hospital mortality in diabetic subjects with ischemic stroke. Plasma glucose levels are predictor for in-hospital mortality in both diabetic and nondiabetic subjects.

show abstract

Section: Discussionmentioning

confidence: 99%

Predictors of In-Hospital Mortality after Acute Ischemic Stroke in Subjects with and without Diabetes Mellitus

Papazafiropoulou¹,

Sotiropoulos²,

Skliros³

et al. 2009

TOGMJ

View full text Add to dashboard Cite

show abstract

“…On contrary to this study, Millionis et al showed significant relation between serum uric acid level and male gender in patient with acute ischaemic stroke (P=0.01). 9 In the present study, overall 56% patients were hypertensive and 28% patients were prehypertensive. Out of 29 hyperuricemic patients, 18 (62%) patients were hypertensive, whereas in patients with normal level of serum uric acid 38 (54%) out of 71 were hypertensive.…”

Section: Discussionmentioning

confidence: 90%

A study to find out relationship in between serum uric acid level and stroke

Tripathi¹,

Hussain²

2017

Int J Adv Med

View full text Add to dashboard Cite

Background: The role of uric acid as a risk factor in cases of acute ischaemic stroke is controversial. The present study was conducted with the aim to study the clinical profile and the incidence of stroke in patients with normal and elevated uric acid and its correlation with other risk factors.Methods: This study was conducted in 100 patients with acute ischaemic stroke who were admitted in NSCB Hospital Jabalpur from August 2009 to July 2010.Clinical records of patients and their serum uric acid level was investigated. The severity of neurological deficit was recorded according to the scandinavian stroke scale (SSS). Patients were followed up during hospital stay and outcome was graded by using modified Rankin’s scale (mRS). Finally, collected data were analyzed using Chi square and student t test wherever appropriate. P value <0.05 was considered significant.Results: A total of 100 patients were included in the study. Majority of the patients (57%) were in the age group of 50 to 70 years. Males (54%) were more affected than females (46%). Out of 100, 71 had normal serum uric acid levels in which 35 (49%) patients were above 60 years of age. 29 of them had hyperuricemia in which 20 (69%) were above the age of 60 years. Of 54 males and 46 females hyperuricemia was observed in 16 (55%) and 13 (45%) patients respectively. A significant correlation was observed between hyperuricemia and hypertension (p<0.05). Non-significant correlation was seen between hyperuricemia, diabetes and hyperlipidemia (p>0.05). Significant, positive correlation p<0.05 was present amongst male alcoholics. Association of uric acid with smoking in acute ischaemic stroke patients was found to be statistically insignificant (p>0.05). Majority (83%) of patients were having infarct in MCA artery territory. Majority of patients 20 (69%) with elevated serum uric acid were having SSS score >30. Statistically insignificant (p>0.05) association was observed between mean mRS score in patients with normal serum uric acid Vs patients with hyperuricemia.Conclusions: The prevalence of hyperuricemia in acute ischaemic stroke patients was lower than in normal population. Age, hypertension and alcoholism amongst males showed statistically significant positive correlation with hyperuricemia in patient with acute ischaemic stroke and hence they are considered to be the significant risk factors.

show abstract

“…15 Similar results were obtained in the study by Milionis et al and in the Rotterdam study (348 versus302 μmol/L). 12,16 Framingham heart study also showed higher serum uric acid in males. 17 Hypertension is the most common modifiable risk factor for stroke.…”

Section: Discussionmentioning

confidence: 90%

“…20 Milionis et al observed that serum uric acid levels were higher in hypertensive subjects compared with nonhypertensives (5.4 ± 1.6 mg/dl versus 5.0 ± 1.6 mg/dl, p= 0.04). 12 Lehto et al also found that the prevalence of hypertension among hyperuricemic subjects was higher as compared to the patients with serum uric acid levels in the normal range (67.3% versus 41.2%, P < 0.001). 21 Similar observation was noted in our study with significantly higher serum uric acid levels among hypertensive patients as compared to normotensive patients (6.4±1.9 versus 5.1±1.3 mg/dl, p = 0.023).…”

Section: Discussionmentioning

confidence: 96%

“…Millinois et al in their study of 163 patients above 70 years for association of serum uric acid and stroke found that serum uric acid is associated with an increased risk for acute ischemic/nonembolic stroke in elderly patients independently of concurrent metabolic derangements. 12 In the German dataset, a maximum male preponderance was found for patients aged between 55 and 64 years (proportion of male patients 0.67 (95% CI: 0.66-0.67), whereas patients older than 84 years revealed a strong overbalance of females (0.27 (0.26-0.28). 13 These results are analogous to the findings in this study with majority of patients belonging to age group between 60-79 years with male preponderance.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Evaluation of serum uric acid in acute ischaemic stroke

et al. 2017

View full text Add to dashboard Cite

Background: The role of serum uric acid as a risk factor for acute ischaemic stroke is controversial and there is little information about it. Present study was done to estimate serum uric acid levels in patients of acute ischaemic stroke and to assess its risk factor potential.Methods: It was a prospective case control study carried out in the department of Medicine at Sri Guru Ramdas Institute of Medical Sciences and Research, Vallah, Sri Amritsar, Punjab, India from January 2015 to July 2016. 50 cases of acute ischaemic stroke were enrolled and were compared with same number of age and sex matched healthy controls. Serum uric acid levels were measured in cases (within 24 hours of stroke evolution). Glasgow coma scale (GCS) score was calculated for cases at time of admission. The results were statistically analysed.Results: Mean serum uric acid level in cases was 6.15±1.91mg/dl whereas it was 5.1±1.4 mg/dl in controls. The difference of serum uric acid levels between cases and controls was statistically significant (p = 0.0054). Patients with poor GCS had higher mean serum uric acid levels as compared to patients with mild or moderate GCS score which was statistically significant(p = 0.0426).Conclusions: Serum uric acid can be used as a marker for increased risk of stroke. Furthermore, serum uric acid can also be used for risk stratification after stroke.

show abstract

Serum uric acid levels and risk for acute ischaemic nonembolic stroke in elderly subjects

Cited by 68 publications

References 31 publications

Predictors of In-Hospital Mortality after Acute Ischemic Stroke in Subjects with and without Diabetes Mellitus

Predictors of In-Hospital Mortality after Acute Ischemic Stroke in Subjects with and without Diabetes Mellitus

A study to find out relationship in between serum uric acid level and stroke

Evaluation of serum uric acid in acute ischaemic stroke

Contact Info

Product

Resources

About