Serum uric acid to serum creatinine ratio predicts neurological deterioration in branch atheromatous disease

Abstract

Background and objectiveBranch atheromatous disease (BAD) makes patients prone to early neurological deterioration (END), resulting in poor prognosis. The aim of this study was to investigate the association between SUA/SCr and END in BAD stroke patients.MethodsWe conducted a retrospective study that included 241 patients with BAD-stroke within 48 h of symptom onset. We divided the patients into the END group and the no END group. END was defined as an NIHSS score increase of more than 2 points within 1 week. SUA/SCr was calculated by the concentration of serum uric acid and creatine (serum uric acid/serum creatine) on admission. Univariate and multivariate analyses were used to identify independent predictors of END in BAD-stroke patients.ResultsEND was observed in 24.1% (58/241) of the patients in our study. Multiple logistic regression analyses showed that SUA/SCr (aOR, 0.716; 95% CI, 0.538–0.952; P = 0.022) and female sex (aOR, 0.469; 95% CI, 0.245–0.898; P = 0.022) were associated with END after adjusting for confounding factors. The predicted value of SUA/Scr for END was a sensitivity of 79.3%, a specificity of 44.8%, and an AUC of 0.609 (95% CI, 0.527–0.691, P < 0.05). The optimal cut-off value was 4.76.ConclusionSUA/SCr was negatively associated with the risk of END in BAD stroke patients.

Lower serum uric acid to serum creatinine ratio as a predictor of poor functional outcome after mechanical thrombectomy in acute ischaemic stroke

“…A large‐scale registry study revealed a significant link between a lower SUA/SCr ratio and poor functional outcome in AIS [16]. It has been reported that, in patients with lenticulostriate artery infarcts, a lower SUA/SCr ratio was an independent predictor of early neurological deterioration, leading to an unfavourable prognosis [17]. Additionally, one study highlighted a positive correlation between SUA/SCr ratio and the stroke recurrence risk in young adults experiencing ischaemic stroke [18].…”

“…At admission, their baseline NIHSS score was 15 (11)(12)(13)(14)(15)(16)(17)(18)(19). A total of 148 (20.2%) patients received intravenous thrombolytic therapy.…”

“…It has been revealed as a useful predictor of mortality rates in hypertensive patients [15]. Studies have established correlations between the SUA/SCr ratio and various dimensions in AIS, including stroke severity, adverse outcome, recurrence rates and early neurological deterioration [16][17][18]. However, the influence of the SUA/SCr ratio on clinical outcome of AIS patients receiving MT remains unknown, particularly with a higher likelihood of association following reperfusion-therapy-induced ischaemia/reperfusion injury.…”

Association between the serum uric acid/serum creatinine ratio and cognitive function in older adults: NHANES in the United States

“…Therefore, assessing the relationship between SUA/SCR and cognitive impairment necessitates considering the influence of renal function. Research has found that SUA/SCR serves as a high-quality biomarker reflecting endogenous UA levels 33 , 34 .…”