Serum Vascular Endothelial Growth Factor in Egyptian Obese Women with Insulin Resistance

Zaki, Moushira Erfan; Basha, Walaa A.; Yousef, Rasha Nazih; Awad, Mona

doi:10.3889/oamjms.2019.156

Cited by 9 publications

(8 citation statements)

References 35 publications

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“…For example, studies have found that DR was significantly associated with mutations in genes that express vascular endothelial growth factor (VEGF) ( 58 ). Additional studies have confirmed that blood VEGF levels were positively correlated with an index of IR ( 59 ). This suggested that expression of the VEGF gene may be one of the common genetic bases between IR and DR. Pro12Ala is located at the amino-terminus of the PPAR-γ 2 gene and was found to be associated with higher insulin sensitivity ( 59 ).…”

Section: Discussionmentioning

confidence: 87%

Association between the triglyceride glucose index and diabetic retinopathy in type 2 diabetes: a meta-analysis

Zhou,

Zhu,

2023

Front. Endocrinol.

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The triglyceride-glucose (TyG) index is an accessible and reliable surrogate indicator of insulin resistance and is strongly associated with diabetes. However, its relationship with diabetic retinopathy (DR) remains controversial. This meta-analysis aimed to assess the relationship between the TyG index and the prevalence of DR. Initial studies were searched from PubMed, Embase, Web of Science, and China National Knowledge Infrastructure (CNKI) electronic databases. The retrieval time range was from the establishment of the database to June 2023. Pooled estimates were derived using a random-effects model and reported as odds ratio (OR) with 95% confidence intervals (CIs). Two researchers independently assessed the methodological quality of the included studies. The Newcastle-Ottawa Quality Scale (NOS) was utilized to assess cohort studies or case-control studies. The Agency for Healthcare Research and Quality (AHRQ) methodology checklist was applied to assess cross-sectional studies. Ten observational studies encompassing 13716 patients with type 2 diabetes were included in the meta-analysis. The results showed that a higher TyG index increased the risk of DR compared with a low TyG index (OR: 2.34, 95% CI: 1.31-4.19, P < 0.05). When the index was analyzed as a continuous variable, consistent results were observed (OR: 1.48, 95% CI: 1.12-1.97, P < 0.005). There was no significant effect on the results of the sensitivity analyses excluding one study at a time (P all < 0.05). A higher TyG index may be associated with an increased prevalence of DR in patients with type 2 diabetes. However, high-quality cohort or case-control studies are needed to further substantiate this evidence.Systematic review registrationhttps://www.crd.york.ac.uk/PROSPERO/, identifier CRD42023432747.

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Section: Discussionmentioning

confidence: 87%

Association between the triglyceride glucose index and diabetic retinopathy in type 2 diabetes: a meta-analysis

Zhou,

Zhu,

2023

Front. Endocrinol.

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“…However, this study also had several limitations: (1) this intriguing observation requires further study to determine whether the prominent IL-6, IL-8, and MCP-1 adipokines affect CSCs by knockdown them, and future studies using larger patient cohorts will help define their total prognostic and predictive value in IBC, and (2) the interpretation of the results obtained for the IL-6 , IL-8 , and MCP-1 cytokines in correlation with BMI was limited because the patients were nearly obese due to the increased obesity rate in Egypt [ 68 ], which may contribute to BC. Therefore, only obese patients with BC were enrolled in the present study exclusively.…”

Section: Discussionmentioning

confidence: 99%

Role of adipose tissue-derived cytokines in the progression of inflammatory breast cancer in patients with obesity

et al. 2022

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Background Inflammatory breast cancer (IBC) represents a deadly aggressive phenotype of breast cancer (BC) with a unique clinicopathological presentation and low survival rate. In fact, obesity represents an important risk factor for BC. Although several studies have identified different cellular-derived and molecular factors involved in IBC progression, the role of adipocytes remains unclear. Cancer-associated adipose tissue (CAAT) expresses a variety of adipokines, which contribute to tumorigenesis and the regulation of cancer stem cell (CSC). This research investigated the potential effect of the secretome of CAAT explants from patients with BC on the progression and metastasis of the disease. Methods This study established an ex-vivo culture of CAAT excised from IBC (n = 13) vs. non-IBC (n = 31) patients with obesity and profiled their secretome using a cytokine antibody array. Furthermore, the quantitative PCR (qPCR) methodology was used to validate the levels of predominant cytokines at the transcript level after culture in a medium conditioned by CAAT. Moreover, the impact of the CAAT secretome on the expression of epithelial-mesenchymal transition (EMT) and cells with stem cell (CSC) markers was studied in the non-IBC MDA-MB-231 and the IBC SUM-149 cell lines. The statistical differences between variables were evaluated using the chi-squared test and unpaired a Student’s t-test. Results The results of cytokine array profiling revealed an overall significantly higher level of a panel of 28 cytokines secreted by the CAAT ex-vivo culture from IBC patients with obesity compared to those with non-IBC. Of note, interleukin-6 (IL-6), interleukin-8 (IL-8), and monocyte chemo-attractant protein 1 (MCP-1) were the major adipokines secreted by the CAAT IBC patients with obesity. Moreover, the qPCR results indicated a significant upregulation of the IL-6, IL-8, and MCP-1 mRNAs in CAAT ex-vivo culture of patients with IBC vs. those with non-IBC. Intriguingly, a qPCR data analysis showed that the CAAT secretome secretions from patients with non-IBC downregulated the mRNA levels of the CD24 CSC marker and of the epithelial marker E-cadherin in the non-IBC cell line. By contrast, E-cadherin was upregulated in the SUM-149 cell. Conclusions This study identified the overexpression of IL-6, IL-8, and MCP-1 as prognostic markers of CAAT from patients with IBC but not from those with non-IBC ; moreover, their upregulation might be associated with IBC aggressiveness via the regulation of CSC and EMT markers. This study proposed that targeting IL-6, IL-8, and MCP-1 may represent a therapeutic option that should be considered in the treatment of patients with IBC.

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“…Among the VEGF subfamily members, VEGF-A is particularly crucial, and its receptors, VEGFR-1 (Flt-1) and VEGFR-2 (KDR/Flk-1) play vital roles in processes like angiogenesis, vascular permeability activity, and cell migration ( 317 , 324 ). Elevated serum VEGF levels were observed in obese patients and this elevation has associations with visceral fat index and BMI ( 297 , 300 , 325 ). Meanwhile, overweight individuals with asthma exhibited higher levels of VEGF-A compared to their non-overweight counterparts ( 326 ).…”

Section: The Association Between Asthma Obesity and Alterations In Ai...mentioning

confidence: 98%

“…The remodeling of ASM induced by VEGF may be associated with the activation of the RhoA/ROCK pathway ( 296 ). The interaction between leptin and VEGF in obesity-induced ASM remodeling should be considered, as higher levels of serum VEGF were observed in individuals with obesity compared to the control group ( 297 – 300 ).…”

Section: The Association Between Asthma Obesity and Alterations In Ai...mentioning

confidence: 99%

Impact of obesity on airway remodeling in asthma: pathophysiological insights and clinical implications

Listyoko,

Okazaki,

Harada

et al. 2024

Front. Allergy

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The prevalence of obesity among asthma patients has surged in recent years, posing a significant risk factor for uncontrolled asthma. Beyond its impact on asthma severity and patients' quality of life, obesity is associated with reduced lung function, increased asthma exacerbations, hospitalizations, heightened airway hyperresponsiveness, and elevated asthma-related mortality. Obesity may lead to metabolic dysfunction and immune dysregulation, fostering chronic inflammation characterized by increased pro-inflammatory mediators and adipocytokines, elevated reactive oxygen species, and reduced antioxidant activity. This chronic inflammation holds the potential to induce airway remodeling in individuals with asthma and obesity. Airway remodeling encompasses structural and pathological changes, involving alterations in the airway's epithelial and subepithelial layers, hyperplasia and hypertrophy of airway smooth muscle, and changes in airway vascularity. In individuals with asthma and obesity, airway remodeling may underlie heightened airway hyperresponsiveness and increased asthma severity, ultimately contributing to the development of persistent airflow limitation, declining lung function, and a potential increase in asthma-related mortality. Despite efforts to address the impact of obesity on asthma outcomes, the intricate mechanisms linking obesity to asthma pathophysiology, particularly concerning airway remodeling, remain incompletely understood. This comprehensive review discusses current research investigating the influence of obesity on airway remodeling, to enhance our understanding of obesity's role in the context of asthma airway remodeling.

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Serum Vascular Endothelial Growth Factor in Egyptian Obese Women with Insulin Resistance

Cited by 9 publications

References 35 publications

Association between the triglyceride glucose index and diabetic retinopathy in type 2 diabetes: a meta-analysis

Association between the triglyceride glucose index and diabetic retinopathy in type 2 diabetes: a meta-analysis

Role of adipose tissue-derived cytokines in the progression of inflammatory breast cancer in patients with obesity

Impact of obesity on airway remodeling in asthma: pathophysiological insights and clinical implications

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