Serum vaspin as a predictor of severity and prognosis in acute ischemic stroke patients

Ping, Zhang; Wang, Guihua; Gui, Yongkun; Guo, Zhenfang; Ren, Ruifang; Sun, Youxuan; Song, Jinggui

doi:10.1080/1028415x.2020.1806191

Cited by 7 publications

(4 citation statements)

References 44 publications

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“…It is a 395-amino acid protein belonging to the serpin family, demonstrating 40% 1-antitrypsin similarity and exerting in vitro insulin-sensitizing actions by inhibiting the activity of human kallikrein 7 to prevent insulin cleavage. Similar to other adipokines such as adiponectin, the concentration of plasma Vaspin is 2.5-fold greater in women than in males [5].…”

Section: Introductionmentioning

confidence: 78%

“…As shown in Table (5) serum Omentin was remarkably and negatively interrelated with the levels of GS-CSF (r = -0.8447, p = 0.0005), and CCL-18 (r= -0.7058, p = 0.0103), whereas there were non-remarkable positive interrelationships between Omentin level with IL-8 (r = 0.4364, p = 0.1561). The data demonstrated that Omentin was negatively and non-significantly interrelated with the level of IL-1β (r= -0.5366, p =0.0786).…”

Section: Interrelationships Of Omentin With Interrelate Studied Param...mentioning

confidence: 91%

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The potential value of some adipokines and cytokines as diagnostic biomarkers for prostate cancer

Yousif,

Ismail

2023

Revista Romana De Medicina De Laborator

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Background: The role of Adipokines and proinflammatory cytokines is said to be crucial in the development of prostate cancer. Vaspin, Chemerin, Omentin, Interleukins IL-1β, interleukin-8 (IL8), Colony-stimulating factor (GM-CSF) and CC chemokine ligand 18 (CCL18) have all been proven to take part in tumor growth and progression. Aim of the study: The study aimed to explore circulating novel adipocytokines, such as serum of Vaspin, Chemerin and Omentin levels in patients with prostate cancer and to determine the level of selected proinflammatory cytokines (CCL18, IL-8, IL1, and GM-CSF). Methods: Three groups were included in the current study: Group (1) :32 patients with metastatic prostate cancer who received chemotherapy, Group (2): 30 untreated patients with nonmetastatic prostate cancer, and Group (3): 30 healthy controls. ELISA technique was used to assess serum levels of Vaspin, Chemerin, Omentin, CCL18, IL-8, IL1, and GM-CSF). Results: The Prostate cancer group exhibited higher serum levels of Vaspin, Chemerin, Omentin, CCL18, IL-8, IL1, and GM-CSF compared to the control group. Chemotherapy-treated patients exhibited significantly increased levels of the pro-inflammatory cytokines (IL-8) and Adipokines (Vaspin and Omentin) and decreased levels of the pro-inflammatory cytokines (IL-1) and Adipokines (Chemerin). The correlation analysis showed a significant positive correlation of serum Chemerin with Vaspin (r = 0.957, p-value<0.0001), IL-8 (r = 0.9475, p-value < 0.0001) and IL-1β (r = 0.7771, p-value < 0.0029). Omentin and GS-CSF levels showed a non-significant positive correlation with Chemerin level (r = 0.1259; p = 0.6967).) and (r = 0.4247; p = 0.1688), respectively. While significant negative correlation was found between (Chemerin) with CCL-18 (r = –0.7916, p = 0.0022), serum Vaspin was significantly and negatively correlated with the levels of CCL-18 (r = –0.9349, p < 0.0001), whereas there was a significant positive correlation between Vaspin level with IL-8 (R=0.9995, p <0.0001); IL-1β(r = 0.561, p = 0.0057). The data demonstrated that Vaspin was positively and non-significantly correlated with the level of GS-CSF (r = 0.1437, p =0.656); serum Omentin was significantly and negatively correlated with the levels of GS-CSF (r = –0.8447, p = 0.0005), and CCL-18 (r= –0.7058, p = 0.0103), whereas there was a non-significant positive correlation between Omentin level with IL-8 (r = 0.4364, p = 0.1561). The data demonstrated that Omentin was negatively and non-significantly correlated with the level of IL-1β (r= –0.5366, p =0.0786). Conclusions: This study indicated increased levels of serum Vaspin, Chemerin, Omentin, Interleukins IL-1β, interleukin-8 (IL8), Colony-stimulating factor (GM-CSF) and CC chemokine ligand 18 (CCL18) in patients with Prostate cancer. These findings suggest that the cytokines, and adipokines, whose levels were elevated in the chemotherapy-treated patients may be involved in the pathophysiology of prostate cancer. Vaspin, Chemerin and Omentin might play an important role in Prostate cancer progression through their association with Adipokines and proinflammatory cytokines. More studies are needed to investigate the possible role of Vaspin, Chemerin and Omentin as potential markers in the development of Prostate cancer.

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Section: Introductionmentioning

confidence: 78%

Section: Interrelationships Of Omentin With Interrelate Studied Param...mentioning

confidence: 91%

The potential value of some adipokines and cytokines as diagnostic biomarkers for prostate cancer

Yousif,

Ismail

2023

Revista Romana De Medicina De Laborator

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“…According to the critical appraisal in Table 1, seven studies, three cross-sectional, two cohorts, one case-control, and one interventional in vivo, suggested that vaspin has a protective and beneficial effect on atherosclerosis progression (Aust et al, 2009;Jung et al, 2011;Kastl et al, 2020;Li et al, 2012;Zhang et al, 2013Zhang et al, , 2016Zhang et al, , 2020. However, those three cross-sectional studies failed to indicate the cause-effect relationship of vaspin with atherosclerosis.…”

Section: Vaspin and Atherosclerosismentioning

confidence: 99%

“…Therefore, the population race and its most suitable SNP type need to be considered in every vaspin serological study. O n l i n e F i r s t Von Loeffelholz et al, 2010El-Mesallamy et al, 2011Ye et al, 2009Youn et al, 2008Yang,li, and Wang, 2017Yang,li, and Wang et al, 2017Dai et al, 2016Moradi et al, 2016Liu et al, 2020Yaug et al, 2015Lal et al, 2018De et al, 2019Esaki et al, 2014El-Lebedy et al, 2018Cura et al, 2014Aust et al, 2009Li et al, 2012Jung et al, 2011Zhang et al, 2016Kastl et al, 2020Zhang et al, 2020Zhang et al, 2013 O n l i n e F i r s t Vaspin showed a beneficial role in endothelial cells; meanwhile, vaspi...…”

Section: Serum Vaspin Level and Its Genetic Expressionmentioning

confidence: 99%

Serum vaspin role in atherosclerosis and glucose tolerance disorders: A systematic review and meta-analysis

Danuaji¹,

Suroto²,

Purwanto³

et al. 2022

J App Pharm Sc

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Visceral adipose tissue-derived serine protease inhibitor (vaspin) is an adipokine associated with insulin resistance (IR), obesity, and inflammation. Serum vaspin role and significant alteration in its levels in type 2 diabetes mellitus (T2DM) and atherosclerotic disease have been severally reported. Nevertheless, these immense changes and this role have been studied, and different results were observed across several atherosclerosis and glucose tolerance disordersassociated studies due to differences in design, sample size and baseline parameters, and population race. Hence, we performed a systematic review to establish and summarize the latest results of serum vaspin level alteration and its role in atherosclerosis and glucose tolerance disorders. The studies from databases such as PubMed, ScienceDirect, Scopus, and Google Scholar were employed. The keywords included vaspin, atherosclerosis, coronary heart disease, ischemic heart disease, stroke, insulin, diabetes, glucose intolerance, metabolic syndrome, and obesity. Boolean Logic "AND" was used to combine each keyword and specify the results. Twenty-three articles were selected based on the suitability of their title/abstract and the inclusion criteria for this review topic. Two review authors independently evaluated the risk of bias based on the Cochrane risk of bias tool. Furthermore, we used RevMan 5.3 to present and synthesize the results. Critical appraisal of each obtained article showed that high vaspin levels were associated with a lower risk of atherosclerosis. Meanwhile, 10 articles about vaspin and glucose tolerance disorders showed that high vaspin levels were associated with a higher risk of developing T2DM. Meta-analysis showed atherosclerotic diseases and glucose tolerance disorders versus normal healthy (MD −0.43; 95% CI: −1.35 to 0.50 and MD −0.07; 95% CI: −0.38 to 0.25, respectively), which indicated higher vaspin levels in the disease group were favored. High serum vaspin levels in arterial plaque diseases were considered a protective mechanism to prevent further endothelial inflammation, injury, and atherosclerosis. This similar observation was found in obesity or T2DM patients as a compensatory mechanism for IR conditions.

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Serpin A12 (Vaspin) as a Serine Protease Inhibitor

Maghsoudi

Hassani

Mirnia

et al. 2022

Biomarkers in Diabetes

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Serum vaspin as a predictor of severity and prognosis in acute ischemic stroke patients

Cited by 7 publications

References 44 publications

The potential value of some adipokines and cytokines as diagnostic biomarkers for prostate cancer

The potential value of some adipokines and cytokines as diagnostic biomarkers for prostate cancer

Serum vaspin role in atherosclerosis and glucose tolerance disorders: A systematic review and meta-analysis

Serpin A12 (Vaspin) as a Serine Protease Inhibitor

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