Serum Vaspin Concentration in Elderly Type 2 Diabetes Mellitus Patients with Differing Body Mass Index: A Cross-Sectional Study

Yang, Wei; Li, Yun; Tian, Tian; Wang, Li

doi:10.1155/2017/4875026

Cited by 16 publications

(14 citation statements)

References 25 publications

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“…Vaspin a novel adipocytokine, visceral adipose tissue-derived serine protease inhibitor with insulin-sensitizing effects, may improve the metabolism of glucose, lipids and decrease glucose concentration (18). as well as plays inhibitory roles against inflammation in vascular smooth muscle (19) . However, the overall impact of vaspin on glucose dysregulation in humans is not fully known.…”

Section: Discussionmentioning

confidence: 99%

Changes of Salivary Interleukine-17, Apelin, Omentin and Vaspin Levels in Normal Subjects and Diabetic Patients with Chronic periodontitis

Sarhat¹,

Rmaid²,

Jabir³

2020

ATMPH

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Background: Chronic periodontitis is a chronic inflammatory disease which is multifactorial. Diabetes mellitus is one of the major systemic factors to influence the severity of chronic periodontitis. Therefore, the aim of current study was to assess salivary biomarkers of Interleukine-17(IL-17), apelin, omentin and vaspin as putative candidates in the potential association between Diabetes mellitus and Chronic periodontitis. Methods: Whole saliva samples were collected from sixty adults sex and agematched patients who were further divided into two groups; healthy (control group; n = 30) and diabetic individuals with chronic periodontitis (n = 30). Salivary IL-17, apelin, omentin andvaspin concentrations were determined by standard enzyme-linked immune-sorbent assay. Results: Salivary levels of IL-17, apelin and vaspin were significantly higher in diabetic patients with periodontitis group compared to control group. On the other hand, salivary levels of omentin were significantly lower in diabetic patients with periodontitis compared to control group. Conclusions: Our study supports the hypothesis that abnormal production of IL-17, apelin, omentin and vaspin can contribute to the pathogenesis of diabetes-related complications including Chronic periodontitis.

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Section: Discussionmentioning

confidence: 99%

Changes of Salivary Interleukine-17, Apelin, Omentin and Vaspin Levels in Normal Subjects and Diabetic Patients with Chronic periodontitis

Sarhat¹,

Rmaid²,

Jabir³

2020

ATMPH

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“…According to other publications, vaspin improves tissue insulin sensitivity 31 and inhibits inflammatory processes in vascular endothelium. 32 , 33 …”

Section: Discussionmentioning

confidence: 99%

Evaluation of biologically active substances promoting the development of or protecting against endometrial cancer

Cymbaluk‐Płoska¹,

Chudecka‐Głaz²,

Jagodzińska³

et al. 2018

OTT

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IntroductionAdipose tissue is considered an endocrine organ and produces a number of biologically active substances.AimsTo consider the role that four adipokines – leptin, omentin-1, vaspin, and galectin-3 – play in the diagnosis of endometrium cancer and to investigate the association between serum concentrations of adipose tissue metabolism products and the diagnostics and prognosis in endometrial cancer.Patients and methodsThe study included 168 patients with body mass index (BMI) >20 kg/m2 admitted due to post-menopausal bleeding.ResultsA receiver operating characteristic curves test was performed to determine the diagnostic values of the proteins tested. For leptin and galectin-3 the area under the curve (AUC) values were 0.79/0.68, while for vaspin and omentin-1 the AUC values were 0.82/0.86 for all study patients. The final model identified the following independent risk factors: glucose concentration, BMI, waist circumference, leptin, and vaspin concentrations. Diagnostic values of leptin and galectin-3 with regard to differentiation between high (Fédération Internationale de Gynécologie Obstétrique [FIGO] III and IV) and low (FIGO I and II) stages of clinical tumor advancement and prediction of tumor grading (G1 vs G3) based on the AUC curve were 0.82/0.70 and 0.80/0.74. The AUC values for vaspin and omentin-1 with respect to differentiation between histopathological advancement and grading were 0.86/0.81 and 0.83/0.77, respectively. Significantly lower values of mean omentin-1 and vaspin concentrations were also demonstrated in cases of lymphatic vessel invasion, lymph node metastases, or deep endometrial infiltration (p=0.002, p=0.01, p=0.003, respectively).ConclusionIt appears that elevated concentrations of leptin, vaspin, and omentin-1 may indicate the presence of endometrial cancer. Furthermore, leptin serum level and vaspin appear to be useful tools in the assessment of clinical staging of endometrial cancer.

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“…Vaspin has also been reported to be associated with insulin regulation and the development of DM, and it has been noted as potential novel biomarker of the early prediction or diagnosis of certain diabetes types [ 26 , 27 ]. Furthermore, a clinical trial identified vaspin levels to be associated with compensatory mechanisms for high BMI and insulin resistance in elderly participants [ 28 ]. Hence, baseline characteristics might affect vaspin levels individually or synergistically.…”

Section: Discussionmentioning

confidence: 99%

Effect of Baseline Characteristics and Tumor Burden on Vaspin Expression and Progressive Disease in Operable Colorectal Cancer

et al. 2020

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Colorectal cancer is a highly heterogeneous malignancy in the Asian population, and it is considered an important prognostic factor for baseline characteristics, tumor burden, and tumor markers. This study investigated the effect of baseline characteristics and tumor burden on tumor marker expression and progressive disease in colorectal cancer by using partial least squares variance-based path modeling (PLS-PM). PLS-PM can be used to evaluate the complex relationship between prognostic variables and progressive disease status with a small sample of measurements and structural models. A total of 89 tissue samples of colorectal cancer were analyzed. Our results suggested that the expression of visceral adipose tissue-derived serpin (vaspin) is a potential indicator of colorectal cancer progression and may be affected by baseline characteristics such as age, sex, body mass index, and diabetes mellitus. Moreover, according to the characteristics of tumor burden, the expression of vaspin was generally higher in each progressive disease patient. The overall findings suggest that vaspin is a potential indicator of the progressive disease and may be affected by the baseline characteristics of patients.

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Serum Vaspin Concentration in Elderly Type 2 Diabetes Mellitus Patients with Differing Body Mass Index: A Cross-Sectional Study

Cited by 16 publications

References 25 publications

Changes of Salivary Interleukine-17, Apelin, Omentin and Vaspin Levels in Normal Subjects and Diabetic Patients with Chronic periodontitis

Changes of Salivary Interleukine-17, Apelin, Omentin and Vaspin Levels in Normal Subjects and Diabetic Patients with Chronic periodontitis

Evaluation of biologically active substances promoting the development of or protecting against endometrial cancer

Effect of Baseline Characteristics and Tumor Burden on Vaspin Expression and Progressive Disease in Operable Colorectal Cancer

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