Serum visfatin in relation to insulin resistance and markers of hyperandrogenism in lean and obese women with polycystic ovary syndrome

Kowalska, Irina; Strączkowski, Marek; Nikołajuk, Agnieszka; Adamska, Agnieszka; Karczewska-Kupczewska, Monika; Otziomek, Elżbieta; Wołczyński, S; Górska, Maria

doi:10.1093/humrep/dem118

Cited by 98 publications

(122 citation statements)

References 23 publications

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“…Only lipocalin-2 levels-to-waist circumference ratio was higher in postmenopausal PCOS than in control women, stressing the role of visceral adipose tissue. Of note, in this study, visfatin levels correlated positively with FAI in postmenopausal PCOS women similar to correlations found in PCOS women of reproductive age (42).…”

Section: Discussionsupporting

confidence: 88%

Study of carbohydrate metabolism indices and adipocytokine profile and their relationship with androgens in polycystic ovary syndrome after menopause

Markopoulos

Valsamakis

Kouskouni

et al. 2013

European Journal of Endocrinology

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Objective: Hyperandrogenism, insulin resistance, and altered adipocytokine levels characterize polycystic ovary syndrome (PCOS) women of reproductive age. Hyperandrogenism persists in postmenopausal PCOS women. In the latter, this study aimed at investigating carbohydrate metabolism, adipocytokines, androgens, and their relationships. Subjects and methods: Blood sampling from overweight postmenopausal women (25 PCOS and 24 ageand BMI-matched controls) at baseline and during oral glucose tolerance test for measurement of insulin and glucose levels, baseline leptin, adiponectin, visfatin, retinol-binding protein 4, lipocalin-2, androgen, and high-sensitivity C-reactive protein (hs-CRP) levels and for calculation of insulin sensitivity (glucose-to-insulin ratio (G/I), quantitative insulin sensitivity check index, and insulin sensitivity index (ISI)), resistance (homeostasis mathematical model assessment-insulin resistance (HOMA-IR)), secretion (D of the area under the curve of insulin (DAUCI), first-phase insulin secretion (1st PHIS), and second-phase insulin secretion (2nd PHIS)), and free androgen indices (FAI). Results: PCOS women had higher insulin secretion indices, hs-CRP, androgen, and FAI levels than controls without differing in baseline glucose, insulin and adipocytokines levels, insulin sensitivity, and resistance indices. In PCOS women, FAI levels correlated positively with baseline insulin, DAUCI, HOMA-IR, and DAUCG and negatively with G/I; hs-CRP levels correlated positively with DAUCI and negatively with ISI. PCOS status, waist circumference, and 17-hydroxyprogesterone (17-OHP) levels were positive predictors for DAUCI. In all women, waist circumference was a negative predictor for ISI; 17-OHP and FAI levels were positive predictors respectively for baseline insulin levels and for 1st PHIS and 2nd PHIS. Conclusions: Early postmenopausal PCOS women are characterized by hyperinsulinemia but attenuated insulin resistance. PCOS status and waist circumference are predictors of hyperinsulinemia while insulin sensitivity correlates negatively with FAI. The differences reported in adipocytokine levels between PCOS and non-PCOS women in reproductive years seem to disappear after menopause. 168 83-90 European Journal of Endocrinology

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Section: Discussionsupporting

confidence: 88%

Study of carbohydrate metabolism indices and adipocytokine profile and their relationship with androgens in polycystic ovary syndrome after menopause

Markopoulos

Valsamakis

Kouskouni

et al. 2013

European Journal of Endocrinology

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“…It has previously been reported that the gene expression and circulating levels of visfatin were increased in women with PCOS compared with age-and BMImatched controls (Tan et al 2006a, Chan et al 2007, Kowalska et al 2007, Panidis et al 2008, Carmina et al 2009, Ozkaya et al 2010, Plati et al 2010, Seow et al 2011, as shown in Table 1. However, several recently published studies did not find a difference in plasma or serum visfatin levels between patients with PCOS and control groups (Guducu et al 2012, Lajunen et al 2012, Olszanecka-Glinianowicz et al 2012.…”

Section: Visfatinmentioning

confidence: 86%

Adipokines in reproductive function: a link between obesity and polycystic ovary syndrome

Chen¹,

Jia²,

Qiao³

et al. 2013

Journal of Molecular Endocrinology

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Polycystic ovary syndrome (PCOS) is the most common endocrinopathy associated with infertility and metabolic disorder in women of reproductive age. Dysfunction of adipose tissue has been implicated in the pathophysiology of PCOS. Increasing evidence shows that the dysregulated expression of adipokines, the secreted products of adipose tissue, plays an important role in the pathology of PCOS. Here, we review the role of several identified adipokines that may act as a link between obesity and PCOS. PCOS also reciprocally influences the profile of adipokines. Insight into the underlying mechanisms will help better understand the pathology of PCOS and identify new therapeutic targets of this syndrome.

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“…Patients with PCOS may present a variety of reproductive and metabolic disturbances, including oligo/ anovulation, polycystic ovary in the ultrasound, and hyperandrogenism, as well as insulin resistance [2]. Moreover, it has been shown that beta cell dysfunction is present in PCOS individuals [3].…”

Section: Introductionmentioning

confidence: 99%

Serum concentrations of betatrophin and its association with indirect indices of insulin resistance and beta cell function in women with polycystic ovary syndrome

Adamska¹,

Łebkowska²,

Jacewicz³

et al. 2017

EJEA

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Introduction. Data underline the role of betatrophin in glucose homeostasis. Polycystic ovary syndrome (PCOS) is characterized by insulin resistance (IR). The aim of our study was to investigate the relationship of serum betatrophin concentrations with indirect indices of IR and insulin secretion in women with PCOS, compared to the control group. Methods. The study group comprised 43 women with PCOS and 16 controls. IR was assessed by HOMA-IR and Matsuda index. Insulin secretion was evaluated with HOMA-B. An oral glucose tolerance test (OGTT) with estimation of serum betatrophin concentrations was performed. Results. Glucose load resulted in an increase in serum betatrophin concentrations in the control group (p = 0 02). Serum betatrophin concentrations at 120 min of OGTT were lower in women with PCOS than in the control group (p = 0 02). We observed positive correlations between baseline serum betatrophin concentrations and HOMA-IR (r = 0 39, p = 0 008), negative correlations with Matsuda index (r = −0 31, p = 0 004), and a positive relationship with HOMA-B (r = 0 38, p = 0 01) in women with PCOS. Multiple regression analysis revealed that HOMA-B (β = 0 47, p = 0 001) was an independent factor connected to serum betatrophin levels in PCOS. Conclusions. Serum concentrations of betatrophin are connected with insulin resistance and beta cell function and did not change after glucose load in women with PCOS.

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Serum visfatin in relation to insulin resistance and markers of hyperandrogenism in lean and obese women with polycystic ovary syndrome

Abstract: Visfatin is associated with insulin resistance and markers of hyperandrogenism in lean PCOS patients.

Cited by 98 publications

References 23 publications

Study of carbohydrate metabolism indices and adipocytokine profile and their relationship with androgens in polycystic ovary syndrome after menopause

Study of carbohydrate metabolism indices and adipocytokine profile and their relationship with androgens in polycystic ovary syndrome after menopause

Adipokines in reproductive function: a link between obesity and polycystic ovary syndrome

Serum concentrations of betatrophin and its association with indirect indices of insulin resistance and beta cell function in women with polycystic ovary syndrome

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