Serum Vitamin D and Its Upregulated Protein, Thioredoxin Interacting Protein, Are Associated With Beta-Cell Dysfunction in Adult Patients With Type 1 and Type 2 Diabetes

Omar, Doaa F.; Kamal, Mohamed M.; El-Hefnawy, Mohamed H; El‐Mesallamy, Hala O.

doi:10.1016/j.jcjd.2018.02.012

Cited by 19 publications

(16 citation statements)

References 43 publications

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“…From a pathophysiological point of view, vitamin D levels and thioredoxin interacting protein were associated with different beta-cell dysfunction markers, indicating their potential abilities to predict the beta-cell status in people with diabetes [145].…”

Section: Diabetes Mellitusmentioning

confidence: 99%

Consensus statement from 2nd International Conference on Controversies in Vitamin D

Giustina

Adler

Binkley

et al. 2020

Rev Endocr Metab Disord

224

169

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The 2 nd International Conference on Controversies in Vitamin D was held in Monteriggioni (Siena), Italy, September 11-14, 2018. The aim of this meeting was to address ongoing controversies and timely topics in vitamin D research, to review available data related to these topics and controversies, to promote discussion to help resolve lingering issues and ultimately to suggest a research agenda to clarify areas of uncertainty. Several issues from the first conference, held in 2017, were revisited, such as assays used to determine serum 25-hydroxyvitamin D [25(OH)D] concentration, which remains a critical and controversial issue for defining vitamin D status. Definitions of vitamin D nutritional status (i.e. sufficiency, insufficiency and deficiency) were also revisited. New areas were reviewed, including vitamin D threshold values and how they should be defined in the context of specific diseases, sources of vitamin D and risk factors associated with vitamin D deficiency. Non-skeletal aspects related to vitamin D were also discussed, including the reproductive system, neurology, chronic kidney disease and falls. The therapeutic role of vitamin D and findings from recent clinical trials were also addressed. The topics were considered by 3 focus groups and divided into three main areas: 1) "Laboratory": assays and threshold values to define vitamin D status; 2) "Clinical": sources of vitamin D and risk factors and role of vitamin D in non-skeletal disease and 3) "Therapeutics": controversial issues on observational studies and recent randomized controlled trials. In this report, we present a summary of our findings.

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Section: Diabetes Mellitusmentioning

confidence: 99%

Consensus statement from 2nd International Conference on Controversies in Vitamin D

Giustina

Adler

Binkley

et al. 2020

Rev Endocr Metab Disord

224

169

View full text Add to dashboard Cite

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“…In addition insulin treatment has been shown to normalize TRX activity and inhibit TXNIP levels in animal models. Insulin functions via phosphatidylinositol kinase (PI3K) to degrade TXNIP (26) and metformin reduces TXNIP levels by activating AMPK (27).…”

Section: Correlation Of Txnip With Oxidative Stress and Inflammatory mentioning

confidence: 99%

Correlation Between Thioredoxin-Interacting Protein and Nerve Conduction Velocity in Patients With Type 2 Diabetes Mellitus

et al. 2020

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Aims: To investigate the correlation between thioredoxin-interacting protein (TXNIP) and peripheral nerve conduction velocity (NCV) in patients with type 2 diabetes mellitus. Methods: In total, 338 patients with type 2 diabetes mellitus (T2DM) were included in this study. We collected the clinical data and measured the motor conduction velocities of the bilateral ulnar nerve, median nerve, tibial nerve, and common peroneal nerve, and the sensory conduction velocities of the ulnar nerve, median nerve, sural nerve, and superficial peroneal nerve. According to the results, the patients were divided into two groups: normal peripheral nerve conduction group (NCVN group) and abnormal peripheral nerve conduction group (NCVA group). The two groups were then compared in terms of the conventional biochemical index and the sugar metabolic index as well as the serum levels of TXNIP, reduced glutathione (GSH), total superoxide dismutase (SOD), malondialdehyde (MDA), and tumor necrosis factor alpha (TNF-α). The correlation between TXNIP and NCV was also analyzed. Results: Compared with the NCVN group, the TXNIP and MDA values were significantly increased in the NCVA group (P < 0.05). Among the patients with T2DM, age, fasting glucose, SDBG, and TXNIP were risk factors for NCV abnormality, while vitamin D3 was a protective factor. After adjusting for related confounding factors, TXNIP was significantly correlated with NCV (P < 0.05). Among the patients with T2DM, TXNIP was an independent risk factor for left ulnar motor conduction velocity (MCV), right ulnar MCV, left median MCV, and right median MCV. TNF-α was identified as a positive influencing factor for serum TXNIP, while serum TXNIP was a positive factor for TNF-α and MDA (both P < 0.05). Conclusion: Serum TXNIP is related to NCV in T2DM patients. In combination with oxidative stress and inflammation, TXNIP may affect diabetic peripheral neuropathy (DPN).

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“…Functionally, TXNIP dissociates from thioredoxin (TRX), combines directly with NLRP3 and activates it ( 28 ). In addition, recent studies have demonstrated that TXNIP is upregulated in diabetes-related inflammation ( 20 , 29 ). In patients with diabetes, hyperglycemia has been suggested to stimulate the expression of TXNIP ( 30 ).…”

Section: Introductionmentioning

confidence: 99%

Inhibitor of RAGE and glucose‑induced inflammation in bone marrow mesenchymal stem cells: Effect and mechanism of action

Jiang

Wang

et al. 2020

Mol Med Rep

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The occurrence and development of hyperglycemia-induced inflammation is associated with increased expression of receptor for advanced glycation end products (RAGE) and inflammatory factors, including IL-1β, TnF-α and il-6. Previous studies have reported that the nucleotide-binding oligomerization domain-like receptor protein 3 (NLRP3) inflammasome interacts with thioredoxin-interacting protein (TXNIP) and serves a crucial role in inflammation. FPS-ZM1 has been identified as target inhibitor of RAGE and has been shown to exert an anti-inflammatory effect in vitro. However, the underlying mechanism by which FPS-ZM1 impacts high glucose (HG)-induced inflammation in bone marrow mesenchymal stem cells (BMScs) remains unclear. The present study explored the regulatory effect of FPS-ZM1 on HG-induced inflammation in BMSCs. Furthermore, the role of the TXNIP/NLRP3 inflammasome signaling pathway in the regulatory effects of FPS-ZM1 on HG-induced inflammation was studied. cell viability was determined using cell counting Kit-8 and western blotting was used to assess the protein expression levels of raGe. eliSa was used to determine the levels of inflammatory markers. Reverse transcription-quantitative Pcr and western blotting were used to measure the mrna and protein expression levels of TXniP, caspase-1, thioredoxin (TRX), NLRP3 and apoptosis-related speck-like protein containing card (aSc). The results revealed that in BMScs, raGe expression was stimulated by HG, an effect which was reversed by treatment with FPS-ZM1. in addition, HG activated inflammatory factors, such as TnF-α, IL-1β and il-6; however, their levels were suppressed when cells were treated with FPS-ZM1 or the TXNIP/NLRP3 pathway inhibitor, resveratrol (Res). Furthermore, FPS-ZM1 inhibited the mrna and protein expression levels of TXniP, caspase-1, NLRP3 and ASC, and promoted TRX expression, which was consistent with the effects of res. These findings indicated that FPS-ZM1 may attenuate HG-induced inflammation in BMSCs. Furthermore, the TXNIP/NLRP3 inflammasome signaling pathway mediated the molecular mechanism underlying this effect.

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Serum Vitamin D and Its Upregulated Protein, Thioredoxin Interacting Protein, Are Associated With Beta-Cell Dysfunction in Adult Patients With Type 1 and Type 2 Diabetes

Cited by 19 publications

References 43 publications

Consensus statement from 2nd International Conference on Controversies in Vitamin D

Consensus statement from 2nd International Conference on Controversies in Vitamin D

Correlation Between Thioredoxin-Interacting Protein and Nerve Conduction Velocity in Patients With Type 2 Diabetes Mellitus

Inhibitor of RAGE and glucose‑induced inflammation in bone marrow mesenchymal stem cells: Effect and mechanism of action

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