Serum vitamin D is associated with non-alcoholic fatty liver disease in Chinese males with normal weight and liver enzymes

Hao, Yaping; Ma, Xiaojing; Luo, Yuqi; Ni, Jie; Dou, Jianxin; Hu, Yaqin; Zhu, Jing; Bao, Yuqian; Jia, Weiping

doi:10.1038/aps.2014.48

Cited by 31 publications

(28 citation statements)

References 25 publications

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“…We previously demonstrated that serum vitamin D levels were much lower in patients with NAFLD than in patients without NAFLD. In our previous study, serum 25(OH)D 3 levels were inversely correlated with NAFLD in 514 Chinese men with normal total body fat and liver enzymes . Moreover, a strong association between serum 25(OH)D 3 levels and NAFLD was found by our study team in 451 Chinese postmenopausal women .…”

Section: Discussionsupporting

confidence: 55%

“…The relationship between vitamin D and NAFLD has also been a research hotspot in recent years . We previously demonstrated that serum vitamin D levels were much lower in patients with NAFLD than in patients without NAFLD.…”

Section: Discussionmentioning

confidence: 98%

“…In addition, FGF23 is a key regulator of the in vivo metabolism of vitamin D, maintaining the balance of mineral metabolism through the interactions of calcium, phosphorus, and vitamin D . We have previously found that NAFLD patients have remarkably decreased serum vitamin D levels compared to subjects without NAFLD in Chinese population . However, there have been no reports on the relationship between FGF23 and NAFLD.…”

Section: Introductionmentioning

confidence: 99%

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The association of serum FGF23 and non‐alcoholic fatty liver disease is independent of vitamin D in type 2 diabetes patients

Shen

et al. 2018

Clin Exp Pharma Physio

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Recent studies have shown that circulating fibroblast growth factor (FGF) 23 and vitamin D levels are closely correlated with insulin resistance. The aim of this study was to investigate the relationship among serum FGF 23 levels, serum 25-hydroxyvitamin D [25(OH)D] levels, and non-alcoholic fatty liver disease (NAFLD) in Chinese patients with type 2 diabetes mellitus (T2DM). This study enrolled 331 hospitalized T2DM patients (209 patients with NAFLD and 122 patients without NAFLD). Serum FGF23 levels were measured using a sandwich enzyme-linked immunosorbent assay. Serum 25(OH)D levels were determined by an electrochemiluminescence immunoassay. NAFLD was diagnosed by hepatic ultrasound, and the fatty liver index (FLI) was calculated to quantify hepatic steatosis. Results showed that T2DM patients with NAFLD had significantly higher serum FGF23 levels (44.17 [37.92-51.30] pg/mL vs 40.21 [34.07-48.33] pg/mL, P = .002), but lower serum 25(OH)D levels (16.43 [12.70-21.37] ng/mL vs 19.59 [13.78-26.26] ng/mL, P = .002) than those without NAFLD. Moreover, the incidence rate of NAFLD increased with increasing serum FGF23 levels and decreased with increasing 25(OH)D levels (both P < .05). Logistic regression analysis showed that both serum FGF23 and 25(OH)D levels were independent factors for NAFLD (both P < .05). Furthermore, a multiple stepwise regression analysis also revealed that both serum FGF23 and 25(OH)D levels were independently correlated with FLI (both P < .01). In conclusion, both high FGF23 and low vitamin D levels showed an independent relationship with NAFLD in Chinese T2DM patients, indicating that FGF23 and vitamin D function via different regulatory pathways in the liver.

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Section: Discussionsupporting

confidence: 55%

Section: Discussionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

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The association of serum FGF23 and non‐alcoholic fatty liver disease is independent of vitamin D in type 2 diabetes patients

Shen

et al. 2018

Clin Exp Pharma Physio

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“…Furthermore, studies with biopsy‐diagnosed NAFLD, a gold standard in NAFLD diagnosis, demonstrated a protective effect of vitamin D against NAFLD . Moreover, previous research from our group has demonstrated an association between vitamin D levels, visceral fat and NAFLD in men …”

Section: Introductionmentioning

confidence: 58%

“…11,12 Moreover, previous research from our group has demonstrated an association between vitamin D levels, visceral fat and NAFLD in men. 13,14 Both gender and menopausal status are primary influencing factors for vitamin D levels. However, little research has been performed to evaluate the relationship between serum vitamin D levels and both abdominal obesity and NAFLD in Chinese postmenopausal women.…”

Section: Introductionmentioning

confidence: 99%

Serum vitamin D levels are inversely related with non‐alcoholic fatty liver disease independent of visceral obesity in Chinese postmenopausal women

Pan

et al. 2015

Clin Exp Pharma Physio

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The aim of the present study was to investigate the association between serum vitamin D levels and both visceral adipose and with non-alcoholic fatty liver disease (NAFLD) in Chinese postmenopausal women. Four hundred and fifty-one postmenopausal women between 45 and 74 years of age (mean (± SD) age 57.3 ± 4.6 years) were enrolled in the study. All subjects participated in the Shanghai Obesity Study between June and August 2011 and underwent abdominal magnetic resonance imaging and an abdominal ultrasonography. Patients with a visceral fat area (VFA) ≥ 80 cm(2) were classified as abdominally obese. Serum 25-hydroxyvitamin D3 (25(OH)D3 ) levels were measured with an electrochemiluminescence immunoassay. The prevalence of NAFLD in the study population was 34.8% (n = 157). Women with abdominal obesity had significantly lower serum 25(OH)D3 levels than those without abdominal obesity (median (interquartile range) 11.23 (8.64-14.12) vs 12.56 (9.41-15.98) ng/mL, respectively; P < 0.01). Regardless of abdominal obesity status, serum 25(OH)D3 levels in patients with NAFLD were lower than those without non-NAFLD (11.14 (8.63-13.81) vs 12.92 (9.48-16.37) ng/mL (P < 0.05) for those without abdominal obesity; 10.86 (8.61-13.56) vs 11.55 (8.82-16.38) ng/mL (P < 0.05) for those with abdominal obesity). Partial correlation analyses demonstrated a negative correlation between serum 25(OH)D3 levels and VFA (P < 0.05). Logistic regression analysis revealed that high serum 25(OH)D3 levels were a protective factor against NAFLD after adjusting for risk factors such as VFA. In conclusion, independent of visceral obesity, vitamin D is inversely correlated with NAFLD in Chinese postmenopausal women.

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Prevalence and Profile of Nonalcoholic Fatty Liver Disease in Lean Adults: Systematic Review and Meta‐Analysis

et al. 2020

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Data on prevalence and profile of nonalcoholic fatty liver disease (NAFLD) among individuals who are lean (normal body mass index) is unclear. Published data from studies comparing lean with obese NAFLD or with healthy subjects on prevalence, comorbidities, liver chemistry and histology, and metabolic/inflammatory markers were analyzed. Data were reported as odds ratio and 95% confidence interval for categorical variables and difference of means for continuous variables. Analysis of 53 studies on 65,029 subjects with NAFLD (38,084 lean) and 249,544 healthy subjects showed a prevalence of lean NAFLD at 11.2% in the general population. Among individuals with NAFLD, the prevalence of lean NAFLD was 25.3%. Lean NAFLD versus healthy subjects had higher odds for abnormalities on metabolic profile, including metabolic syndrome and its components, renal and liver function, and patatin-like phospholipase domain-containing protein 3 (PNPLA3) G allele; and inflammatory profile, including uric acid and C-reactive protein.The abnormalities were less severe among lean versus obese NAFLD on metabolic syndrome with its components, renal and liver chemistry, liver stiffness measurement, PNPLA3 and transmembrane 6 superfamily member 2 polymorphisms, and uric acid levels as markers of inflammation. Lean NAFLD had less severe histologic findings, including hepatocyte ballooning, lobular inflammation, NAFLD activity score, and fibrosis stage. Limited data also showed worse outcomes between obese versus lean NAFLD. Conclusion: Lean NAFLD is a distinct entity with metabolic, biochemical, and inflammatory abnormalities compared to healthy subjects and a more favorable profile, including liver histology of steatohepatitis and fibrosis stage, compared to obese NAFLD. We suggest that prospective multicenter studies examine long-term hepatic and extrahepatic outcomes in individuals with lean NAFLD. (Hepatology Communications 2020;4:953-972).N onalcoholic fatty liver disease (NAFLD) is one of the most common liver diseases in the world, with a global prevalence of approximately 25% and a prevalence of 24% in North America. (1,2) The incidence is increasing, especially in the Western world, due to the rising prevalence of obesity in the general population. (3) Approximately 15% to 20% of patients with NAFLD progress to the more advanced stage of nonalcoholic steatohepatitis (NASH), with a risk to progress to advanced liver

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Serum vitamin D is associated with non-alcoholic fatty liver disease in Chinese males with normal weight and liver enzymes

Cited by 31 publications

References 25 publications

The association of serum FGF23 and non‐alcoholic fatty liver disease is independent of vitamin D in type 2 diabetes patients

The association of serum FGF23 and non‐alcoholic fatty liver disease is independent of vitamin D in type 2 diabetes patients

Serum vitamin D levels are inversely related with non‐alcoholic fatty liver disease independent of visceral obesity in Chinese postmenopausal women

Prevalence and Profile of Nonalcoholic Fatty Liver Disease in Lean Adults: Systematic Review and Meta‐Analysis

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