Serum vitamin D levels correlate to coronary artery disease severity: a retrospective chart analysis

Sogomonian, Robert; Alkhawam, Hassan; Jolly, J.; Vyas, Neil; Ahmad, Sumair; Haftevani, Emma Moradoghli; Al-Khazraji, Ahmed; Finkielstein, Dennis; Vittorio, Timothy J.

doi:10.1080/14779072.2016.1190273

Cited by 15 publications

(14 citation statements)

References 29 publications

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“…In this regard, the need for increased attention has been proposed, suggesting the role of vitamin D deficiency as a risk factor for CAD. However, there remains insufficient evidence owing to controversial reports in the literature both in favor of18 and against19 this concept. However, genetic polymorphism of the vitamin D receptor could modify its role 20.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of vitamin D levels in relation to coronary CT angiographic findings in an Iranian population

Moradi¹,

Foroutanfar²

2017

VHRM

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BackgroundVitamin D deficiency, as a predisposing factor for coronary artery disease (CAD), is a subject of increasing interest. However, its role as a risk factor has not been proven. This study aimed to investigate the relationship between serum vitamin D levels and CAD.Materials and methodsUsing a cross-sectional design, 180 patients who were candidates for coronary computed tomography angiography (CCTA) were selected. Serum levels of vitamin D were measured and compared with the results of CCTA (including calcium score, and presence and severity of coronary artery involvement due to atherosclerotic plaques).ResultsThe mean age of the participants was 60.5±10.6 years and the mean serum vitamin D level was 26.2±15.9 ng/dL (range, 3.5–83.2 ng/dL). Overall, 6.1% of the participants (n=11) had vitamin D deficiency, 56.1% (n=101) had insufficient levels of vitamin D, and 37.8% (n=68) had sufficient levels of vitamin D. The mean serum vitamin D level was significantly lower in patients with severe CAD (P=0.004). The serum vitamin D level in the “positive for CAD” group was 20.98 ng/mL, significantly lower than the level in the “negative for CAD” group (30.47 ng/mL; P<0.001). The mean calcium score among participants was 533.5±87.9. Based on the Spearman test, a significant negative correlation (−0.21) was detected between the serum vitamin D level and coronary artery calcium score (CACS) (P=0.005). Conversely, the mean CACS in the vitamin D deficient group was significantly higher than in the insufficient and sufficient vitamin D groups (P<0.001 for both comparisons).ConclusionVitamin D deficiency was associated with coronary artery calcification and severity of coronary artery stenosis in Iranian patients.

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Section: Introductionmentioning

confidence: 99%

Evaluation of vitamin D levels in relation to coronary CT angiographic findings in an Iranian population

Moradi¹,

Foroutanfar²

2017

VHRM

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“…In meta‐analyses of observational studies, vitamin D deficiency and low intake of this vitamin have been associated with high incidence of cardiovascular disease Circulating levels of 25‐hydroxyvitamin D correlated with the severity of coronary heart disease . Low vitamin D status was associated with increased insulin resistance and decreased levels of high‐density lipoprotein cholesterol (HDL‐C), as well as with increased risk of type 2 DM .…”

Section: Introductionmentioning

confidence: 99%

Different cardiometabolic effects of atorvastatin in men with normal vitamin D status and vitamin D insufficiency

Krysiak

Gilowska

2016

Clinical Cardiology

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Background Vitamin D is suggested to reduce cardiovascular risk. Hypothesis Circulating levels of plasma lipids and other cardiovascular risk factors may differ between statin‐treated patients with different vitamin D status. Methods We studied 3 age‐ and weight‐matched groups of men with elevated low‐density lipoprotein cholesterol (LDL‐C) levels: vitamin D–naïve men with vitamin D insufficiency (group A, n = 18), men with vitamin D deficiency/insufficiency effectively treated with vitamin D preparations (group B, n = 16), and vitamin D–naïve men with normal vitamin D status (group C, n = 16). All patients were then treated with atorvastatin (20 mg daily) for 4 months. Plasma lipids, glucose homeostasis markers, and plasma levels of uric acid, high‐sensitivity C‐reactive protein (hsCRP), homocysteine, and fibrinogen were assessed before and at the end of atorvastatin therapy. Results Study groups did not differ in baseline levels of plasma lipids. Men with vitamin D deficiency or insufficiency effectively treated with vitamin D preparations were characterized by decreased insulin sensitivity and higher circulating levels of hsCRP, homocysteine, and fibrinogen in comparison with the remaining groups of patients. Although atorvastatin decreased plasma levels of total cholesterol and LDL‐C to a similar extent in all study groups, its effect on uric acid, hsCRP, homocysteine, and fibrinogen was more pronounced in patients from groups B and C than in men from group A. Moreover, in patients with vitamin D insufficiency, atorvastatin impaired insulin sensitivity. Conclusions The obtained results indicate that the strength of pleiotropic effects of atorvastatin depends on vitamin D status.

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“…These genetic tests not only focus on the statin gene but other genetic factors influencing it. An inverse relationship has been established between the levels of Vitamin D and severity of coronary artery disease by multiple large scale research trials [18]. Along with that, an association of low levels of vitamin D and statin induced myopathy has also been established.…”

Section: Discussionmentioning

confidence: 92%

Statin Gene Testing: Revolutionary Tool to Increase Compliance and Care in Patients with Statin-Induced Myopathy

Vinson¹,

Badar²,

Gopalakrishnan³

et al. 2019

JCCCVT

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Modern day practitioners are utilizing their time and efforts increasingly to focus on preventative medicine. The correlation between coronary artery disease and hyperlipidemia is well established and this correlation has helped mold the field of preventative cardiovascular medicine. Clinically, patients treated with statins as per the guidelines have shown lower rates of morbidity and mortality over multiple large scale trials [2,4]. Statins have thus become a major first line therapy for treating patients with known hyperlipidemia and coronary artery disease; however, statin medications are often discontinued in a clinical setting with nearly 75% of patients discontinuing therapy within 2 years of initiation [5,7]. The 2009 SEARCH trial first identified an association between the pharmacogenetic test for solute carrier organic anion transporter family member 1B1 (SLCO1B1) and statin-associated symptoms, and has been replicated among numerous other studies, particularly with simvastatin [9-12]. There is some evidence that suggests the implication of SLCO1B1 results can change the prescribing pattern for providers [15]. With the use of this testing technology, clinicians are able to identify and predict possible statin-induced myopathy side effects in patients, increase compliance, and provide a more personalized treatment regimen.

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Serum vitamin D levels correlate to coronary artery disease severity: a retrospective chart analysis

Cited by 15 publications

References 29 publications

Evaluation of vitamin D levels in relation to coronary CT angiographic findings in an Iranian population

Evaluation of vitamin D levels in relation to coronary CT angiographic findings in an Iranian population

Different cardiometabolic effects of atorvastatin in men with normal vitamin D status and vitamin D insufficiency

Statin Gene Testing: Revolutionary Tool to Increase Compliance and Care in Patients with Statin-Induced Myopathy

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