Serum YKL-40 levels may help distinguish exacerbation of post-infectious bronchiolitis obliterans from acute bronchiolitis in young children

Jang, Yoon Young; Park, Hye Jin; Chung, Hai Lee

doi:10.1007/s00431-017-2940-x

Cited by 11 publications

(6 citation statements)

References 33 publications

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“…POSTN is a well‐known biomarker of asthma and T helper 2 cell–associated airway inflammation 10 and has shown an association with airway hyperresponsiveness to methacholine 11 . In a previous study, TGFβ1 levels were significantly higher in patients with PIBO than in controls 12 . However, our study is the first to demonstrate a correlation between TGFβ1 and lung function in children with PIBO.…”

Section: Figurementioning

confidence: 42%

TGFβ1 and POSTN as biomarkers of postinfectious bronchiolitis obliterans and asthma in children

Kang

Ahn

Lee

et al. 2022

Pediatric Pulmonology

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Rationale Asthma and postinfectious bronchiolitis obliterans (PIBO) are common chronic lung diseases in company with wheezing in children. However, it is not clear what is common and unique mechanisms between the two diseases. Thus, we used proteomic analysis to compare differences in biomarkers between children with asthma and PIBO. Methods Overall, 30 healthy children without respiratory underlying diseases, 18 children with asthma and 15 with PIBO were included for this study. Sequential window acquisition of all theoretical mass spectra (SWATH)‐mass spectrometry (MS) was used to measure proteins in plasma samples. To identify specific pathways of each groups, we used the ingenuity pathway analysis (IPA) software. Results We identified and quantified 354 proteins across all 63 samples in the SWATH‐MS analysis. Forty eight proteins were significantly different among 3 groups. The upstream analysis of IPA suggested that inhibitor of nuclear factor kappa B kinase subunit beta (IKBKB) was the upstream inhibitor of 4 differentially expressed proteins (DEPs) in asthma, while the upstream activator in PIBO subjects. Among 4 DEPs, TGF‐β1 in PIBO and periostin in asthma were negatively correlated with forced expiratory volume in 1 s (FEV1), FEV1/forced vital capacity, maximal med‐expiratory flow, and PC20, respectively. Conclusion These findings demonstrate that transforming growth factor β1 and periostin were unique biomarkers of PIBO and asthma in children, respectively. The mechanism regulated by IKBKB may be therapeutically relevant for PIBO and asthma.

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Section: Figurementioning

confidence: 42%

TGFβ1 and POSTN as biomarkers of postinfectious bronchiolitis obliterans and asthma in children

Kang

Ahn

Lee

et al. 2022

Pediatric Pulmonology

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“…A study from South Korea noted a similar duration in the interval as our study (Mean eight months, Min-Max 2-24 months). 14 Bo Qia et al reported a median of three months interval (Min-Max 1-43 month). 15 Another study also showed that PIBO was diagnosed on an average of two years (Min-Max 0,2-7,6 years) after acute illness.…”

Section: Discussionmentioning

confidence: 99%

Post- infectious bronchiolitis obliterans in children: clinical and radiological evaluation and lon- term results

Yazan¹,

Khalif²,

Shadfan³

et al. 2020

Preprint

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Objective: This study aims to evaluate clinical and radiological findings and treatment outcomes of the patients with PIBO. Methods: One hundred fourteen children were enrolled. Initial demographic and clinical findings were evaluated.Pre-and post-treatment symptoms, radiological findings and scores, the number of admissions to the hospital and PICU were compared. Results: Seventy-three patients were male. The median age of the patients at initial pulmonary injury was 7.2 months, the median age at diagnosis was 17.5 months and the median interval from initial injury to diagnosis was 8.5 months. Thirty-five patients had mechanical ventilation history. Persistent wheezing was the most common complaints. The most common radiological findings were peribronchial thickening and air-trapping. Sixty-eight patients were treated with inhaled corticosteroid (IC), systemic corticosteroid (SC) and azithromycin (AZT) combination. 25 patients were treated with only IC, 14 with IC and AZT, and 7 with IC and SC. 82,5% of patients had clinical improvement. Chronic respiratory failure occurred in 11 patients, and three patients died. Bronchiectasis, atelectasis, hyperinflation and air trapping in HRCT improved significantly. Bhalla scores decreased from 8.3 to 6.5 (p= 0,001). IC, SC and AZT combination was effective than the other treatments. Conclusions: This study is one of the largest studies in the literature and one of the few studies that evaluate clinical and radiological outcomes. We found that IC, AZT and SC combination is clinically and radiologically effective in patients with PIBO.

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“…The measurement of serum YKL-40 levels was thus suggested to be helpful in differentiating between exacerbation in PIBO and acute bronchiolitis in small children, and it was concluded that YKL-40 could play a role in the pathogenesis of PIBO. 50 Giubergia V et al, in their study evaluating the distribution of MBL2 polymorphism in children with PIBO, identified significantly more children carrying iMBL genetic variants in the PIBO group when compared to healthy controls, and more patients in the PIBO iMBL group required intensive care and mechanical ventilation. The bronchoalveolar lavage (BAL) of children with PIBO is neutrophil dominant and a significant increase in IL-8 is seen, with the degree of neutrophil increase in BAL being correlated with the BO stage.…”

Section: Mattiello Et Al Reported That Airway Obstructions Varied Between Intermediate To Very Severe In Children Andmentioning

confidence: 99%

Postinfectious Bronchiolitis Obliterans

Yılmaz

Pekcan

2021

J. Pediatr. Acad.

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Childhood bronchiolitis obliterans (BO) is an uncommon complication that is characterized clinically by persistent and continuous obstructive respiratory symptoms, and has been described secondary to various etiologic factors, including drugs, exposure to toxic fumes, allergic reactions, collagen vascular disease or infections. BO occurs most commonly in children after an episode of acute bronchiolitis and is considered a long-term sequela of viral infection.Postinfectious Bronchiolitis Obliterans (PIBO) is characterized by persistent airway obstruction with functional and radiological evidence of small airway involvement that is in general unresponsive to bronchodilator treatment.Although the condition is relatively rare, and its exact incidence is unknown, it is important to keep it in mind. PIBO is complication of lower respiratory tract epithelial injury, and is often misdiagnosed, delaying recognition and potential treatment. A PIBO diagnosis is usually based on a few factors, including a good medical history, positive clinical findings, and lung function test and imaging results, although biopsy and histopathology remain as the optimum diagnostic approach. There have to date been few studies proposing treatments for the condition, and no accepted protocol exists in literature. There is usually a fixed airway obstruction in PIBO. Various treatment approaches have been extrapolated from studies of post bone marrow transplantations and lung transplant BO. The clinical course is variable, and good supportive therapy is essential, with anti-inflammatory therapy often being employed.

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Serum YKL-40 levels may help distinguish exacerbation of post-infectious bronchiolitis obliterans from acute bronchiolitis in young children

Cited by 11 publications

References 33 publications

TGFβ1 and POSTN as biomarkers of postinfectious bronchiolitis obliterans and asthma in children

TGFβ1 and POSTN as biomarkers of postinfectious bronchiolitis obliterans and asthma in children

Post- infectious bronchiolitis obliterans in children: clinical and radiological evaluation and lon- term results

Postinfectious Bronchiolitis Obliterans

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