Serum YKL40: A novel potential link between inflammation and dyslipidemia in acne vulgaris

Abstract

Background Acne vulgaris (AV) is an inflammatory skin disorder that may be associated with metabolic disorders. The relation between lipid profile in acne is not widely investigated. Chitinase‐3‐like protein 1 (YKL‐40) has been found to be implicated in different inflammatory conditions. Aims We aimed at investigating the role YKL‐40 in acne pathogenesis and associated dyslipidemia in acne patients. Patients/Methods This study included 50 acne vulgaris patients and 30 matched control subjects. Serum YKL‐40 in addition to lipid profile were assessed in all studied subjects. Results Serum YKL‐40 level was significantly elevated in acne patients than healthy controls (P < .001). We also found a significant positive correlations between serum YKL‐40, serum TGs, TC, and LDL‐C (P value: .022, .001, .017 respectively) while, a significant negative correlation between serum YKL‐40 and HDL‐c (P value: .036) was detected. Conclusion Our study results suggest that YKL‐40 might have a role in AV pathogenesis. In addition, it could provide a new potential link between inflammation and dyslipidemia observed in acne patients.

Evaluation of the Effect of Oral Isotretinoin on the Level of Serum YKL40 in Acne Vulgaris Patients: A Cross-Sectional Case-Control

“…Patients with acne vulgaris in this study exhibited significantly higher serum levels of YKL-40 than healthy control volunteers. This outcome was consistent with the findings of Khaled et al 4 and Ebrahim et al, 12 who found that acne vulgaris patients had higher serum levels of YKL-40 than healthy control individuals. The median YKL40 level significantly (P value 0.001) decreased before and after receiving isotretinoin.…”

“…Our analysis displayed that there is insignificant difference between serum level of YKL-40 and disease severity (P value = 0.105) with lower level of YKL40 among moderate AV cases (48.5 (21.5-103.5 ng/mL)) compared with severe AV cases (63 (18-181 ng/mL)). Our results were aligned with Ebrahim et al, 12 that noted that the higher level of YKL-40 may only reflect the level of systemic inflammation in AV patients, and its concentration does not relate with the severity of skin changes in the study.…”

“…This may suggest that YKL-40 has a role in different acute and chronic inflammatory disorders. 12 The purpose of the investigation was to compare serum levels of YKL-40 in acne vulgaris patients before and after treatment with oral isotretinoin.…”

Chitinase-3-like Protein 1 (YKL-40): A New Biomarker of Inflammation in Pyoderma Gangrenosum

“…The elevated YKL-40 serum concentration was also reported in patients with acne vulgaris ( 33 ). In the quoted study, no association was found between the YKL-40 level and the severity of the disease, but a positive correlation was observed between the concentration of the discussed factor and total cholesterol, triglycerides, and low-density lipoprotein (LDL) and negative correlation with high-density lipoprotein (HDL), which may indicate other mechanisms leading to the increase in YKL-40 level.…”

Corrigendum

“…In the article by Ebrahim et al, 1 Dr. Fathi's surname had inadvertently been misspelled in the original publication. We apologize for the error.…”