Serum zinc and copper changes after gastrectomy in aged patients with gastric cancer

Hisaki, Toshiko; Furumoto, Toyokazu; Nozaka, Kimiyasu; Kono, Kikuhiro; Odachi, T; Mizumoto, Kiyoshi; Nishimura, Okitsugu; Koga, Shigemasa

doi:10.1007/bf02471425

Cited by 8 publications

(3 citation statements)

References 11 publications

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“…In more detail, H. pylori are the main risk factor in 65-80% of gastric cancers, but in only 2% of such infections (You et al, 2000;Testerman et al, 2006;Vilchis et al, 2009;Janjetic et al, 2010;Zamani et al, 2011). That is to say, despite the worldwide distribution of H pylori infection in patients with gastric disease, only a few number of infected individuals develop gastric cancer, It is important to clarify other factors that may determine risk among those infected with H. pylori (Hisaki et al, 1988;Lin et al, 2002).…”

Section: Introductionmentioning

confidence: 99%

Serum Zinc Status and Helicobacter Pylori Infection in Gastric Disease Patients

Zhang¹,

Wu²,

Niu³

et al. 2012

Asian Pacific Journal of Cancer Prevention

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The role of Helicobacter pylori status and serum zinc value in gastric disease patients and healthy controls were investigated. Cases used in this work were 45 gastric cancer patients, 44 with peptic ulcers, 52 suffering gastritis and 64 healthy controls, all diagnosed histologically with the controls undergoing medical checkups. Helicobacter pylori status and serum levels of Zn were determined by 13C-urea breath test and flame atomic absorption spectrophotometer, respectively. Our study showed that Helicobacter pylori infection has no change in gastritis, peptic ulcer and gastric cancer group, on the contrast, serum levels of Zn were significantly reduced in gastritis, peptic ulcer and gastric cancer group, compared with healthy controls, and the higher the Zn levels are, the more increased risk of gastric cancer. Helicobacter pylori infection is a cause of gastritis, peptic ulcers and even gastric cancer, while serum zinc level is an indicator of protection of gastric membranes against damage.

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Section: Introductionmentioning

confidence: 99%

Serum Zinc Status and Helicobacter Pylori Infection in Gastric Disease Patients

Zhang¹,

Wu²,

Niu³

et al. 2012

Asian Pacific Journal of Cancer Prevention

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“…Such effects are known to result in somatic mutations. Nutritional deficiency of zinc results in delay of wound healing, growth retardation, anorexia, hyposmia and various skin dystrophies [2] Copper (Cu) is closely related with hematopoesis and the metabolism of osseous and connective tissue [3]. Prolonged copper deficiency is associated with anemia, leukemia, and osteoporosis [4].…”

Section: Introductionmentioning

confidence: 99%

Quantitative analysis of copper, zinc and copper/zinc ratio in selected human brain tumors

1993

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Serum copper and zinc concentrations and copper/zinc ratios have been shown to be increased in several types of human malignancies, including human brain tumors. In this study, copper and zinc levels and copper/zinc ratios were determined by atomic absorption analysis in tissue and serum from 29 primary and metastatic brain tumor patients. Metastatic carcinomas and malignant gliomas revealed significantly higher tissue copper concentrations than control tissues and meningiomas. Malignant gliomas demonstrated significantly higher tissue copper/zinc ratios. Both serum copper and copper/zinc ratio were significantly higher in the metastatic carcinoma group than control; however, serum copper levels in malignant glioma patients were not significantly different from control tissues. There were no differences both in the serum and the tissue concentrations of these trace elements in meningiomas and controls. These data suggested that copper, an important angiogenic factors, is accumulated within the malignant tissues of metastatic carcinoma and malignant glioma, but not meningiomas. These findings may have implications regarding angiogenesis in these tumors.

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“…For example, serum copper level was elevated in GC patients and significantly correlated to the survival time (61). Serum Cu: Zn ratio was also elevated, especially in advanced GC (62). Some studies focused on copper/zinc-superoxide dismutase (Cu/Zn-SOD) and found that serum levels of Cu/Zn SOD were significantly up-regulated in GC and higher Cu/Zn SOD levels indicated an increased risk of GC (63).…”

Section: Discussionmentioning

confidence: 99%

Identification of cuproptosis-related subtypes, construction of a prognosis model, and tumor microenvironment landscape in gastric cancer

et al. 2022

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IntroductionCuproptosis is a novel identified regulated cell death (RCD), which is correlated with the development, treatment response and prognosis of cancer. However, the potential role of cuproptosis-related genes (CRGs) in the tumor microenvironment (TME) of gastric cancer (GC) remains unknown.MethodsTranscriptome profiling, somatic mutation, somatic copy number alteration and clinical data of GC samples were downloaded from the Cancer Genome Atlas (TCGA) and the Gene Expression Omnibus (GEO) database to describe the alterations of CRGs from genetic and transcriptional fields. Differential, survival and univariate cox regression analyses of CRGs were carried out to investigate the role of CRGs in GC. Cuproptosis molecular subtypes were identified by using consensus unsupervised clustering analysis based on the expression profiles of CRGs, and further analyzed by GO and KEGG gene set variation analyses (GSVA). Genes in distinct molecular subtypes were also analyzed by GO and KEGG gene enrichment analyses (GSEA). Differentially expressed genes (DEGs) were screened out from distinct molecular subtypes and further analyzed by GO enrichment analysis and univariate cox regression analysis. Consensus clustering analysis of prognostic DEGs was performed to identify genomic subtypes. Next, patients were randomly categorized into the training and testing group at a ratio of 1:1. CRG Risk scoring system was constructed through logistic least absolute shrinkage and selection operator (LASSO) cox regression analysis, univariate and multivariate cox analyses in the training group and validated in the testing and combined groups. Real-time quantitative polymerase chain reaction (RT-qPCR) was used to evaluate the expression of key Risk scoring genes. Sensitivity and specificity of Risk scoring system were examined by using receiver operating characteristic (ROC) curves. pRRophetic package in R was used to investigate the therapeutic effects of drugs in high- and low- risk score group. Finally, the nomogram scoring system was developed to predict patients’ survival through incorporating the clinicopathological features and CRG Risk score.ResultsMost CRGs were up-regulated in tumor tissues and showed a relatively high mutation frequency. Survival and univariate cox regression analysis revealed that LIAS and FDX1 were significantly associated with GC patients’ survival. After consensus unsupervised clustering analysis, GC patients were classified into two cuproptosis molecular subtypes, which were significantly associated with clinical features (gender, age, grade and TNM stage), prognosis, metabolic related pathways and immune cell infiltration in TME of GC. GO enrichment analyses of 84 DEGs, obtained from distinct molecular subtypes, revealed that DEGs primarily enriched in the regulation of metabolism and intracellular/extracellular structure in GC. Univariate cox regression analysis of 84 DEGs further screened out 32 prognostic DEGs. According to the expression profiles of 32 prognostic DEGs, patients were re-classified into two gene subtypes, which were significantly associated with patients’ age, grade, T and N stage, and survival of patients. Nest, the Risk score system was constructed with moderate sensitivity and specificity. A high CRG Risk score, characterized by decreased microsatellite instability-high (MSI-H), tumor mutation burden (TMB) and cancer stem cell (CSC) index, and high stromal and immune score in TME, indicated poor survival. Four of five key Risk scoring genes expression were dysregulated in tumor compared with normal samples. Moreover, CRG Risk score was greatly related with sensitivity of multiple drugs. Finally, we established a highly accurate nomogram for promoting the clinical applicability of the CRG Risk scoring system.DiscussionOur comprehensive analysis of CRGs in GC demonstrated their potential roles in TME, clinicopathological features, and prognosis. These findings may improve our understanding of CRGs in GC and provide new perceptions for doctors to predict prognosis and develop more effective and personalized therapy strategies.

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Serum zinc and copper changes after gastrectomy in aged patients with gastric cancer

Cited by 8 publications

References 11 publications

Serum Zinc Status and Helicobacter Pylori Infection in Gastric Disease Patients

Serum Zinc Status and Helicobacter Pylori Infection in Gastric Disease Patients

Quantitative analysis of copper, zinc and copper/zinc ratio in selected human brain tumors

Identification of cuproptosis-related subtypes, construction of a prognosis model, and tumor microenvironment landscape in gastric cancer

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