This paper presents a bibliometric overview of the publications in the principal international journal Process Safety and Environmental Protection (PSEP) from 1990 to 2020 retrieved in the Web of Science (WoS) database to explore the evolution in safety and environmental engineering design and practice, as well as experimental or theoretical innovative research. Therefore, based on the WoS database and the visualization of similarities (VOS) viewer software, the bibliometric analysis and scientometric mapping of the literature have been performed from the perspectives of document types, publication and citation distribution over time, leading authors, countries (regions), institutions, the corresponding collaboration networks, most cited publications and references, focused research fields and topics, research trend evolution over time, etc. The paper provides a comprehensive and quantitative overview and significant picture representation for the journal’s leading and evolutionary trends by employing specific aforementioned bibliometric analysis factors. In addition, by reviewing the evolutionary trends of the journal and the proposed investigated factors, such as the influential works, main research topics, and the research frontiers, this paper reveals the scientific literature production’s main research objectives and directions that could be addressed and explored in future studies.