Recently the competition between firms is transforming from “firm vs. firm” to “ecosystem vs. ecosystem”. To fulfil the personalized customer requirements for a high-quality product-service in the age of servitization and sustainability, it is difficult for an individual actor to realize it. The product-service system (PSS) is naturally an integration of product and service. The final product-service of PSS that depends on a tangible product and intangible service, calls for value co-creation of multi-stakeholders. However, most existing related works have investigated PSS from the perspective of a supply chain or network, PSS in the view of an ecosystem of multi-stakeholders lacks sufficient exploration, especially the topic on the relationship between product-service and stakeholders. To fill the gap, this paper proposed a framework for the PSS ecosystem with quality function deployment (QFD) and fuzzy analytic network process (fuzzy ANP) to determine the stakeholders by clarifying the relationship between the final integrated product-service and stakeholders. Firstly, the PSS ecosystem structure was presented, including the stakeholders. Secondly, a model with the three-stage fuzzy ANP-QFD approach to determine stakeholders was employed. Thirdly, the specific process of the three-stage approach was presented. An illustrative case study of the automobile aftermarket was presented to verify the proposed model and approach. Discussions and future directions concluded this paper.