With the growing number of academic studies being published each year, scientific knowledge is expanding at an unparalleled rate. Therefore, analyzing the scientific production in a particular research area to identify future research directions and streams has become inevitable. This study adopted a two-step methodological approach—bibliometric (294 articles) and content-based analyses (63 articles)—to dissect tourism and real estate literature. Using different analytical modules and software to answer the six proposed research questions, the study findings reveal that the tourism and real estate literature still does not follow a specific research direction but is rather intertwined with many other research areas. Additionally, the results highlight some distinctive points in the tourism and real estate literature, including how it is predominantly composed of practical studies based on primary data and applied in various spatial units as case studies (e.g., coastal areas, cities and national and international units). Finally, this study explains how the findings will be beneficial for identifying the future research agenda in the tourism real estate scientific field by providing a clear roadmap for the research streams of this field.