Sesamol ameliorates dextran sulfate sodium-induced depression-like and anxiety-like behaviors in colitis mice: the potential involvement of the gut–brain axis

Xia, Bing; Liu, Xiaoning; Li, Xiaohan; Wang, Yutang; Wang, Danna; Kou, Rong-Wei; Zhang, Li; Shi, Renjie; Jin, Yufeng; Bo, Xiaowei; Liu, Qian; Zhao, Beita; Liu, Xuebo

doi:10.1039/d1fo03888e

Cited by 25 publications

(20 citation statements)

References 71 publications

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“…The microbiome is an essential part of body organs through its role in major physiological activities. A healthy individual is supposed to have a broad set of bacteria that has several microbial genes that aid in the physiological processes [ 55 ]. The GBA is made up of the central system, the enteric nervous system, and the digestive system, which operate in coordination [ 56 ].…”

Section: Pathogenesis Of Psdmentioning

confidence: 99%

Pathophysiology and Current Drug Treatments for Post-Stroke Depression: A Review

Frank

Gruenbaum

Zlotnik

et al. 2022

IJMS

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Post-stroke depression (PSD) is a biopsychosocial disorder that affects individuals who have suffered a stroke at any point. PSD has a 20 to 60 percent reported prevalence among stroke survivors. Its effects are usually adverse, can lead to disability, and may increase mortality if not managed or treated early. PSD is linked to several other medical conditions, including anxiety, hyper-locomotor activity, and poor functional recovery. Despite significant awareness of its adverse impacts, understanding the pathogenesis of PSD has proved challenging. The exact pathophysiology of PSD is unknown, yet its complexity has been definitively shown, involving mechanisms such as dysfunction of monoamine, the glutamatergic systems, the gut-brain axis, and neuroinflammation. The current effectiveness of PSD treatment is about 30–40 percent of all cases. In this review, we examined different pathophysiological mechanisms and current pharmacological and non-pharmacological approaches for the treatment of PSD.

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Section: Pathogenesis Of Psdmentioning

confidence: 99%

Pathophysiology and Current Drug Treatments for Post-Stroke Depression: A Review

Frank

Gruenbaum

Zlotnik

et al. 2022

IJMS

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“…The results illustrate that sesamol is a novel nutritional intervention strategy for preventing IBD and its symptoms of anxiety and depression. As one of its many effects, sesamol has been shown to improve BDNF levels by upregulating the BDNF/TrkB/CREB signaling pathway [ 142 ].…”

Section: Resultsmentioning

confidence: 99%

Antidepressive Effect of Natural Products and Their Derivatives Targeting BDNF-TrkB in Gut–Brain Axis

Liaqat

Parveen

Kim

2022

IJMS

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Modern neurological approaches enable detailed studies on the pathophysiology and treatment of depression. An imbalance in the microbiota–gut–brain axis contributes to the pathogenesis of depression. This extensive review aimed to elucidate the antidepressive effects of brain-derived neurotrophic factor (BDNF)-targeting therapeutic natural products and their derivatives on the gut–brain axis. This information could facilitate the development of novel antidepressant drugs. BDNF is crucial for neuronal genesis, growth, differentiation, survival, plasticity, and synaptic transmission. Signaling via BDNF and its receptor tropomyosin receptor kinase B (TrkB) plays a vital role in the etiopathogenesis of depression and the therapeutic mechanism of antidepressants. This comprehensive review provides information to researchers and scientists for the identification of novel therapeutic approaches for neuropsychiatric disorders, especially depression and stress. Future research should aim to determine the possible causative role of BDNF-TrkB in the gut–brain axis in depression, which will require further animal and clinical research as well as the development of analytical approaches.

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“…Neuroinflammation is correlated with the progression of anxiety, and many dietary natural products and nutrients have anti-inflammatory bioactivity to reduce anxiety-related symptoms. For example, sesamol is a liposoluble lignan isolated from sesame products and an in vivo study found that it reduced anxiety-like behaviors of mice with inflammatory bowel disease through decreasing neuroinflammatory responses via inhibition of TLR-4/NF-κB pathway [ 109 ]. Furthermore, in a rat model of LPS-induced anxiety, honey had protective effects against anxiety by decreasing the expression levels of TNF-α and IL-6 [ 20 ].…”

Section: Anxietymentioning

confidence: 99%

“…For instance, goat milk is a good source of fat acids and an in vivo study showed goat milk fats palliated anxiety-like behaviors of rats by decreasing MDA levels and increasing GSH levels in the brain [ 114 ]. In a mouse model of dextran sulfate sodium-induced inflammatory bowel disease, sesamol attenuated anxiety-like behaviors by stimulating the Nrf2 antioxidant signaling pathway [ 109 ]. Additionally, tangeretin decreased anxiety-like behaviors of rats with post-traumatic stress disorder, which was associated with promoting the activation of Nrf2 signaling pathway [ 115 ].…”

Section: Anxietymentioning

confidence: 99%

“…A great number of evidence has supported that dysfunction of neurotransmitter systems would result in impairment of intracellular signal processing, which was involved in the neurobiological processes of anxiety [ 125 ]. It was found that supplement with sesamol improved anxiety induced by inflammatory bowel disease through repairing synaptic impairments, upregulating the expression levels of norepinephrine and serotonin, increasing BDNF levels via the BDNF/TrkB/CREB signaling pathway [ 109 ]. Furthermore, breadfruit pulp exerted protective effects against anxiety in zebrafish by regulating the serotoninergic system [ 126 ].…”

Section: Anxietymentioning

confidence: 99%

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Possible Effects and Mechanisms of Dietary Natural Products and Nutrients on Depression and Anxiety: A Narrative Review

Zhou

et al. 2022

Antioxidants

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Depression and anxiety are severe public health problems and have attracted more and more attention from researchers of food science and nutrition. Dietary natural products and nutrients, such as fish, coffee, tea, n-3 PUFA, lycopene, and dietary fiber, could play a vital role in the prevention and management of these diseases. The potential mechanisms of action mainly include inhibiting inflammation, ameliorating oxidative stress, modulating the microbiota–gut–brain axis, suppressing hypothalamic–pituitary–adrenal axis hyperactivity, and regulating the levels of monoamine neurotransmitters. In this narrative review, we summarize the most recent advancements regarding the effects of dietary natural products and nutrients on depression and anxiety, and their underlying mechanisms are discussed. We hope that this paper can provide a better understanding of the anti-depressive and anxiolytic action of dietary natural products, and that it is also helpful for developing dietary natural products for functional food, dietary supplements, or auxiliary agents for the prevention and management of these diseases.

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Sesamol ameliorates dextran sulfate sodium-induced depression-like and anxiety-like behaviors in colitis mice: the potential involvement of the gut–brain axis

Abstract: Inﬂammatory bowel disease (IBD) is accompanied by some psychiatric disorders, including anxiety and depression. Sesamol has been reported to alleviate colitis symptoms and depression-like behaviors caused by chronic unpredictable mild...

Cited by 25 publications

References 71 publications

Pathophysiology and Current Drug Treatments for Post-Stroke Depression: A Review

Pathophysiology and Current Drug Treatments for Post-Stroke Depression: A Review

Antidepressive Effect of Natural Products and Their Derivatives Targeting BDNF-TrkB in Gut–Brain Axis

Possible Effects and Mechanisms of Dietary Natural Products and Nutrients on Depression and Anxiety: A Narrative Review

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