Sesquiterpene Lactones

Hohmann, Miriam S. N.; Longhi-Balbinot, Daniela T.; Guazelli, Carla F. S.; Navarro, Suelen A.; Zarpelon, Ana C.; Casagrande, Rúbia; Arakawa, Nilton Syogo; Verri, Waldiceu A.

doi:10.1016/b978-0-444-63601-0.00007-7

Cited by 17 publications

(5 citation statements)

References 114 publications

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“…Polyphenols and sesquiterpene lactones, known to be abundant in LNL, have been shown to possess inhibitory effects on the JAK/STAT pathway [59]. Among them, costunolide has been found to influence CD4+ T cell regulation, affecting T cell differentiation and thereby demonstrating efficacy in reducing IL-13 secretion [60].…”

Section: Discussionmentioning

confidence: 99%

Efficacy of Laurus nobilis L. for Tight Junction Protein Imbalance in Leaky Gut Syndrome

Shin,

Kim,

Song

et al. 2024

Nutrients

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Laurus nobilis L. (LNL) belongs to the evergreen Lauraceae family. It is native to the Mediterranean and widely distributed in the southern United States, Europe, and the Middle East. LNL is rich in active ingredients of the sesquiterpene lactone series and has been reported to have antioxidant, anti-inflammatory, and anticancer effects. And parthenolide, known as a sesquiterpene lactone-based compound, inhibits the activation of lipopolysaccharide-binding protein (LBP), which is a major trigger for leaky gut syndrome. However, the effectiveness of LNL in improving the state of increased intestinal permeability has not yet been reported. Therefore, we demonstrated the efficacy of LNL, which is known to be rich in parthenolide, in improving intestinal permeability induced by IL-13. We investigated the improvement in permeability and analyzed major tight junction proteins (TJs), permeability-related mechanisms, weight and disease activity indices, and corresponding cytokine mechanisms. LNL maintained TJs homeostasis and clinical improvement by reducing increased claudin-2 through the inhibition of IL-13/STAT6 activation in TJ-damaged conditions. These results are expected to be effective in preventing leaky gut syndrome through the TJ balance and to further improve intestinal-related diseases, such as inflammatory bowel disease.

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Section: Discussionmentioning

confidence: 99%

Efficacy of Laurus nobilis L. for Tight Junction Protein Imbalance in Leaky Gut Syndrome

Shin,

Kim,

Song

et al. 2024

Nutrients

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“…4.1 Searching for Sesquiterpenoid Lactones Which are Agonists of hTAS2Rs 3,4,5,9,10,14,30,39,40 These compounds are of research interest because both sesquiterpenoid lactones and agonists of the mentioned hTAS2Rs displayed anti-inflammatory potential in various experimental studies (Hall et al, 1979;Hohmann et al, 2016;Grassin-Delyle et al, 2019). The advanced search with the following keywords "sesquiterpenoid lactone" AND " 3-beta-hydroxypelenolide, absinthin, alpha-santonin, arglabin, artemorin, costunolide, parthenolide, picrotoxinin), while the more advanced search with the following keywords "sesquiterpenoid lactone" AND "…”

Section: Examples Of Usementioning

confidence: 99%

“…These compounds are of research interest because both sesquiterpenoid lactones and agonists of the mentioned hTAS2Rs displayed anti-inflammatory potential in various experimental studies ( Hall et al, 1979 ; Hohmann et al, 2016 ; Grassin-Delyle et al, 2019 ). The advanced search with the following keywords “sesquiterpenoid lactone” AND “[hTAS2R3] OR [hTAS2R4] OR [hTAS2R5] OR [hTAS2R9] OR [hTAS2R10] OR [hTAS2R14] OR [hTAS2R30] OR [hTAS2R39] OR [hTAS2R40]” yielded 9 compounds (3-beta-hydroxy dihydrocostunolide, 3-beta-hydroxypelenolide, absinthin, alpha-santonin, arglabin, artemorin, costunolide, parthenolide, picrotoxinin), while the more advanced search with the following keywords “sesquiterpenoid lactone” AND “[hTAS2R3] OR [TAS2R4] OR [TAS2R5] OR [TAS2R9] OR [hTAS2R10] OR [hTAS2R14] OR [TAS2R30] OR [TAS2R39] OR [TAS2R40]” AND “antiinflammatory” produced only 6 compounds (absinthin, alpha-santonin, arglabin, artemorin, costunolide, parthenolide).…”

Section: Examples Of Usementioning

confidence: 99%

PlantMolecularTasteDB: A Database of Taste Active Phytochemicals

et al. 2022

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“…SQ lactones are cyclic SQs with a fused α-methylene-γ-lactone ring. Subclasses include eudesmanolide, guaianolide, pseudoquaianolide, germacranolide, and xanthanolide (Figure 3) [41]. SQ lactones are formed via a mevalonic acid pathway by plants [42] (Figure 4).…”

Section: Structures Of Sq Lactonesmentioning

confidence: 99%

The Complexity of Sesquiterpene Chemistry Dictates Its Pleiotropic Biologic Effects on Inflammation

et al. 2022

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Sesquiterpenes (SQs) are volatile compounds made by plants, insects, and marine organisms. SQ have a large range of biological properties and are potent inhibitors and modulators of inflammation, targeting specific components of the nuclear factor-kappaB (NF-κB) signaling pathway and nitric oxide (NO) generation. Because SQs can be isolated from over 1600 genera and 2500 species grown worldwide, they are an attractive source of phytochemical therapeutics. The chemical structure and biosynthesis of SQs is complex, and the SQ scaffold represents extraordinary structural variety consisting of both acyclic and cyclic (mono, bi, tri, and tetracyclic) compounds. These structures can be decorated with a diverse range of functional groups and substituents, generating many stereospecific configurations. In this review, the effect of SQs on inflammation will be discussed in the context of their complex chemistry. Because inflammation is a multifactorial process, we focus on specific aspects of inflammation: the inhibition of NF-kB signaling, disruption of NO production and modulation of dendritic cells, mast cells, and monocytes. Although the molecular targets of SQs are varied, we discuss how these pathways may mediate the effects of SQs on inflammation.

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Sesquiterpene Lactones

Cited by 17 publications

References 114 publications

Efficacy of Laurus nobilis L. for Tight Junction Protein Imbalance in Leaky Gut Syndrome

Efficacy of Laurus nobilis L. for Tight Junction Protein Imbalance in Leaky Gut Syndrome

PlantMolecularTasteDB: A Database of Taste Active Phytochemicals

The Complexity of Sesquiterpene Chemistry Dictates Its Pleiotropic Biologic Effects on Inflammation

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