2022
DOI: 10.1371/journal.pone.0273652
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Sestrin 2 levels are associated with emphysematous phenotype of COPD

Abstract: Sestrins (Sesns) are a family of highly conserved stress-inducible proteins and various stresses have been shown to strongly up-regulate them. Sestrin 2 (Sesn2) deficiency has been shown to partially suppress pulmonary emphysema. The aim of this study was to evaluate Sesn2 levels in COPD patients and its possible associations with the presence of emphysema and blood eosinophils. All patients underwent lung function testing and high-resolution computed tomography (HRCT) of the chest. The presence of emphysemato… Show more

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Cited by 3 publications
(1 citation statement)
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“…Sestrins are a highly conserved family of proteins produced in response to stress. There is only one Sestrin in invertebrates, and three Sestrins in vertebrates, namely Sestrin 1-3 [15]. Sertrin1 and Sestrin2 were found to reduce ROS levels and inhibit mammalian target of rapamycin C1 (mTORC1) activity in colorectal cancer cells, suggesting that Sestrin may slow the progression of related diseases by inhibiting these two molecules [16].…”
Section: Discussionmentioning
confidence: 99%
“…Sestrins are a highly conserved family of proteins produced in response to stress. There is only one Sestrin in invertebrates, and three Sestrins in vertebrates, namely Sestrin 1-3 [15]. Sertrin1 and Sestrin2 were found to reduce ROS levels and inhibit mammalian target of rapamycin C1 (mTORC1) activity in colorectal cancer cells, suggesting that Sestrin may slow the progression of related diseases by inhibiting these two molecules [16].…”
Section: Discussionmentioning
confidence: 99%