SETDB1 modulates the TGFβ response in Duchenne muscular dystrophy myotubes
Alice Granados,
Maeva Zamperoni,
Roberta Rapone
et al.
Abstract:The histone lysine methyltransferase SETDB1 is involved in muscle differentiation and has been shown as a regulator of the TGFβ pathway in cancer contexts. Here, we investigated the role of SETDB1 in Duchenne muscular dystrophy (DMD) myotubes harboring an overactivated TGFbeta pathway. Our data show that challenging healthy myotubes with TGFbeta induces nuclear accumulation of SETDB1, while in DMD myotubes SETDB1 is constantly accumulated in nuclei in TGFbeta-dependent fashion. SETDB1 loss-of-function (LOF) le… Show more
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