2023
DOI: 10.1101/2023.06.28.546840
|View full text |Cite
Preprint
|
Sign up to set email alerts
|

SETDB1 modulates the TGFβ response in Duchenne muscular dystrophy myotubes

Alice Granados,
Maeva Zamperoni,
Roberta Rapone
et al.

Abstract: The histone lysine methyltransferase SETDB1 is involved in muscle differentiation and has been shown as a regulator of the TGFβ pathway in cancer contexts. Here, we investigated the role of SETDB1 in Duchenne muscular dystrophy (DMD) myotubes harboring an overactivated TGFbeta pathway. Our data show that challenging healthy myotubes with TGFbeta induces nuclear accumulation of SETDB1, while in DMD myotubes SETDB1 is constantly accumulated in nuclei in TGFbeta-dependent fashion. SETDB1 loss-of-function (LOF) le… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

0
0
0

Publication Types

Select...

Relationship

0
0

Authors

Journals

citations
Cited by 0 publications
references
References 46 publications
0
0
0
Order By: Relevance

No citations

Set email alert for when this publication receives citations?